- Activation of Innate Immune System During Viral Infection: Role of Pattern-recognition Receptors (PRRs) in Viral Infection
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Jun EJ, Kim YK
- KMID: 1474157
- J Bacteriol Virol.
- 2009 Sep;39(3):145-157.
- doi: 10.4167/jbv.2009.39.3.145
Innate immunity and adaptive immunity are two major immune responses against pathogens. Innate immunity is responsible for the immediate immune response to pathogens. Pattern-recognition receptors (PRRs) play an important role... -
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- Expression of Interferon Regulatory Factors in Breast Cancer Tissue
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Yoon JH, Park MH, Cho MH, Jaegal YJ, Park CS
- KMID: 2286626
- J Breast Cancer.
- 2006 Jun;9(2):98-104.
- doi: 10.4048/jbc.2006.9.2.98
PURPOSE: As neoplasia is the result of unbalanced cell growth and cell death, alternations in the growth control pathway including the immunity within the individual host-tumor relationship has been attributed... -
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- Intrinsic Cellular Defenses against Virus Infection by Antiviral Type I Interferon
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Boo KH, Yang JS
- KMID: 1779600
- Yonsei Med J.
- 2010 Jan;51(1):9-17.
- doi: 10.3349/ymj.2010.51.1.9
Intrinsic cellular defenses are non-specific antiviral activities by recognizing pathogen-associated molecular patterns (PAMPs). Toll-like receptors (TLRs), one of the pathogen recognize receptor (PRR), sense various microbial ligands. Especially, TLR2, TLR3,... -
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- Promoter methylation and expression levels of selected hematopoietic genes in pediatric B-cell acute lymphoblastic leukemia
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Musialik E, Bujko M, Kober P, Wypych A, Gawle-Krawczyk K, Matysiak M, Siedlecki
- KMID: 1787909
- Blood Res.
- 2015 Mar;50(1):26-32.
- doi: 10.5045/br.2015.50.1.26
BACKGROUND: Precursor B-cell acute lymphoblastic leukemia (B-cell ALL) is the most common neoplasm in children and is characterized by genetic and epigenetic aberrations in hematopoietic transcription factor (TF) genes. This... -
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- Factors Influencing the Response to High Dose Methotrexate-based Vincristine and Procarbazine Combination Chemotherapy for Primary Central Nervous System Lymphoma
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Sung KH, Lee EH, Kim YZ
- KMID: 1777887
- J Korean Med Sci.
- 2011 Apr;26(4):551-560.
- doi: 10.3346/jkms.2011.26.4.551
The authors investigated objective response rate to high dose methotrexate (HDMTX)-based combination chemotherapy in primary central nervous system lymphoma (PCNSL), and sought to identify factors that influence response to HDMTX-based... -
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- Identification of Novel Methylation Markers in Hepatocellular Carcinoma using a Methylation Array
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Shin SH, Kim BH, Jang JJ, Suh KS, Kang GH
- KMID: 1714035
- J Korean Med Sci.
- 2010 Aug;25(8):1152-1159.
- doi: 10.3346/jkms.2010.25.8.1152
Promoter CpG island hypermethylation has become recognized as an important mechanism for inactivating tumor suppressor genes or tumor-related genes in human cancers of various tissues. Gene inactivation in association with... -
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- Development of Monoclonal Antibodies Against Human IRF-5 and Their Use in Identifying the Binding of IRF-5 to Nuclear Import Proteins Karyopherin-alpha1 and -beta1
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Yeon SI, Youn JH, Lim MH, Lee HJ, Kim YM, Choi JE, Lee JM, Shin JS
- KMID: 1782953
- Yonsei Med J.
- 2008 Dec;49(6):1023-1031.
- doi: 10.3349/ymj.2008.49.6.1023
PURPOSE: IRF-5 is a direct transducer of virus-mediated and TLR-mediated signaling pathways for the expression of cytokines and chemokines which form homodimers or heterodimers with IRF-7. However, direct IRF-5-specific monoclonal... -
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