- Application of bispecific antibody against antigen and hapten for immunodetection and immunopurification
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Kim H, Park S, Lee HK, Chung J
- KMID: 2154262
- Exp Mol Med.
- 2013 Sep;45(9):e43.
We present a bispecific antibody that recognizes an antigen and a hapten and can be applied to various biological assays, including immunoblotting and immunoprecipitation. In immunoblot analysis of serum, an... -
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- A ChIP-Seq Data Analysis Pipeline Based on Bioconductor Packages
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Park SJ, Kim JH, Yoon BH, Kim SY
- KMID: 2375580
- Genomics Inform.
- 2017 Mar;15(1):11-18.
- doi: 10.5808/GI.2017.15.1.11
Nowadays, huge volumes of chromatin immunoprecipitation-sequencing (ChIP-Seq) data are generated to increase the knowledge on DNA-protein interactions in the cell, and accordingly, many tools have been developed for ChIP-Seq analysis.... -
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- A Review of Three Different Studies on Hidden Markov Models for Epigenetic Problems: A Computational Perspective
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Lee KE, Park HS
- KMID: 2391489
- Genomics Inform.
- 2014 Dec;12(4):145-150.
- doi: 10.5808/GI.2014.12.4.145
Recent technical advances, such as chromatin immunoprecipitation combined with DNA microarrays (ChIp-chip) and chromatin immunoprecipitation-sequencing (ChIP-seq), have generated large quantities of high-throughput data. Considering that epigenomic datasets are arranged over... -
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- Characterization of cytoplasmic Form of Human CTLA - 4 Molecule
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Cho YJ, Chung YH, Han HS
- KMID: 1548223
- Korean J Immunol.
- 1997 Jun;19(2):219-228.
CTLA-4 (=CD152), a T cell activation antigen, has been known to be homologous to CD28 in its molecular and genomic structure. Both of these two molecules are sharing their counterreceptors,... -
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- Identification of hRad21-Binding Sites in Human Chromosome
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Chin C, Chung BS
- KMID: 2166189
- Genomics Inform.
- 2006 Mar;4(1):11-15.
The aim of this study is to identify hRad21-binding sites in human chromosome, the core component of cohesin complex that held sister chromatids together. After chromatin immunoprecipitation with an hRad21... -
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- Expression of 14-3-3 proteins and Bax in the placenta of preeclampsia
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Park JK, Kim SI, Paik WY
- KMID: 2077758
- Korean J Obstet Gynecol.
- 2007 Jun;50(6):858-864.
OBJECTIVE: Purpose of our study was to examine the expression level of 14-3-3 proteins and Bcl-2 family and to estimate the interaction between 14-3-3 proteins and Bcl-2 family in normal... -
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- Expression of the c-Met Proteins in Malignant Skin Cancers
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Lee YJ, Kim DH, Lee SH, Kim DW, Nam HS, Cho MK
- KMID: 2171949
- Ann Dermatol.
- 2011 Feb;23(1):33-38.
- doi: 10.5021/ad.2011.23.1.33
BACKGROUND: The expression of c-Met is substantially elevated in most malignant human cancers. We therefore searched for c-Met expression and compared the expression level among malignant skin cancers. OBJECTIVE: The aim... -
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- CpG Array Analysis of Histone H3 Lysine 4 Trimethylation by Chromatin Immunoprecipitation Linked to Microarrays Analysis in Peripheral Blood Mononuclear Cells of IgA Nephropathy Patients
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Qi S, Sui W, Yang M, Chen J, Dai Y
- KMID: 1120206
- Yonsei Med J.
- 2012 Mar;53(2):377-385.
- doi: 10.3349/ymj.2012.53.2.377
PURPOSE: The purpose of the present study was to investigate the aberrance of histone H3 lysine 4 trimethylation (H3K4me3) in patients with IgA Nephropathy (IgAN). MATERIALS AND METHODS: In this study,... -
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- Nkx-2.5 Regulates MDR1 Expression via Its Upstream Promoter in Breast Cancer Cells
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Lim JS, Jung GY, Park SY
- KMID: 2442099
- J Korean Med Sci.
- 2019 Apr;34(12):e100.
- doi: 10.3346/jkms.2019.34.e100
BACKGROUND: Increased expression of MDR1 gene is one of the major mechanisms responsible for multidrug resistance in cancer cells. Two alternative promoters, upstream and downstream, are responsible for transcription of... -
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- The Effects of Peroxiredoxin III on Human HeLa Cell Proliferation
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Choi S, Kang S
- KMID: 2054231
- Immune Netw.
- 2003 Dec;3(4):276-280.
- doi: 10.4110/in.2003.3.4.276
BACKGROUND: Peroxidases (Prx) of the peroxiredoxin family reduce hydrogen peroxide and alkyl hydroperoxides to water and alcohol respectively. Hydrogen peroxide is implicated as an intracellular messenger in various cellular responses... -
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- A Role of gamma-subunit in FcgammaRII Signal Transduction of Platelets
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Kim HM, Lim BK
- KMID: 2072453
- Korean J Pediatr Hematol Oncol.
- 1997 Apr;4(1):48-54.
BACKGROUND: The FcgammaRII receptor, the only kind of Fc receptor in the platelet, plays important role for immune-complex mediated platelet activation, which occurs in Heparin induced thrombocytopenia(HIT) or antiphospholipid syndrome.... -
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- Expression of Phospholipase C-gamma1 and gamma2 in Non-Hodgkin's and Hodgkin's Lymphoma
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Eom DW, Kim SS, Woo YJ, Suh JH, Huh J, Paik AR, Kim JH, Ryu SH, Suh PG
- KMID: 1725651
- Korean J Pathol.
- 2000 Feb;34(2):113-118.
Phospholipase C (PLC) plays a role in ligand-mediated signal transduction for cellular activity such as proliferation and differentiation. A recent observation that PLC- gamma1 is highly expressed in some kinds of... -
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- Functional Interaction of HIF-1 and NF-kappaB Increasing the Transcriptional Activation of TNF-alpha Gene in Monocytes
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Park MJ, Lee SM, Ok SJ, Kim HR, Kim HH, Cheong JH
- KMID: 1424262
- Korean J Blood Transfus.
- 2013 Apr;24(1):21-32.
BACKGROUND: Tumor necrosis factor alpha (TNF-alpha) is a pleiotropic cytokine fulfilling a broad variety of immunoregulatory functions. Monocytes and macrophages play a pivotal role in inflammation and immune regulation. NF-kappaB... -
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- Functional analysis of CDC7 protein which is interacted with HPV E6
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Tong SY, Kim JJ, Cho YS, Park JS
- KMID: 1870356
- Korean J Obstet Gynecol.
- 2007 Mar;50(3):459-464.
OBJECTIVE: Human papillomaviruses are associated with the majority of cervical cancers. There is a wide effort focused on searching for the target of the involvement of p53-independent HPV-16E6 interacting proteins.... -
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- Characterization of a Novel Gene in the Extended MHC Region of Mouse, NG29/Cd320, a Homolog of the Human CD320
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Park HJ, Kim JY, Jung KI, Kim TJ
- KMID: 1474586
- Immune Netw.
- 2009 Aug;9(4):138-146.
- doi: 10.4110/in.2009.9.4.138
BACKGROUND: The MHC region of the chromosome contains a lot of genes involved in immune responses. Here we have investigated the mouse NG29/Cd320 gene in the centrometrically extended MHC region... -
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- Identification of CEA-interacting proteins in colon cancer cells and their changes in expression after irradiation
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Yoo BC, Yeo SG
- KMID: 2393559
- Radiat Oncol J.
- 2017 Sep;35(3):281-288.
- doi: 10.3857/roj.2017.00255
PURPOSE: The serum carcinoembryonic antigen (CEA) level has been recognized as a prognostic factor in colorectal cancer, and associated with response of rectal cancer to radiotherapy. This study aimed to... -
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- Current Status and Strategy of microRNA Research for Cartilage Development and Osteoarthritis Pathogenesis
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Asahara H
- KMID: 2350807
- J Bone Metab.
- 2016 Aug;23(3):121-127.
- doi: 10.11005/jbm.2016.23.3.121
MicroRNAs (miRNAs), which are small (~21 nucleotides) non-coding RNAs, are important players in endochondral ossification, articular cartilage homeostasis, and arthritis pathogenesis. Comprehensive and genetic analyses of cartilage-specific or cartilage-related miRNAs... -
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- Apoptosis of the mitochondria protein p32 (gc1qbp) in human ovarian cancer cells
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Won M, Lee S, Kim SJ, Yoon S, Lee K, Ko JJ, Bae J
- KMID: 1479864
- Korean J Obstet Gynecol.
- 2008 Aug;51(8):858-865.
OBJECTIVE: The purpose of the study was to examine a possible physiological function of p32-mediated apoptosis signaling in ovarian cancer cells. METHODS: SK-OV-3 cells were transfected with respective plasmid DNAs, and... -
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- Long Noncoding RNA HEIH Promotes Colorectal Cancer Tumorigenesis via Counteracting miR-939-Mediated Transcriptional Repression of Bcl-xL
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Cui C, Zhai D, Cai L, Duan Q, Xie L, Yu J
- KMID: 2417888
- Cancer Res Treat.
- 2018 Jul;50(3):992-1008.
- doi: 10.4143/crt.2017.226
PURPOSE: Studies have found that long noncoding RNA HEIH (lncRNA-HEIH) is upregulated and facilitates hepatocellular carcinoma tumor growth. However, its clinical significances, roles, and action mechanism in colorectal cancer (CRC)... -
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- Participation of GATA-3 in regulation of bone healing through transcriptional upregulation of bcl-x(L) expression
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Liao MH, Lin PI, Ho WP, Chan WP, Chen TL, Chen RM
- KMID: 2396803
- Exp Mol Med.
- 2017 Nov;49(11):e398.
- doi: 10.1038/emm.2017.182
We have previously demonstrated the expression of GATA-DNA-binding protein (GATA)-3, a transcription factor, in osteoblasts and have verified its function in transducing cell survival signaling. This translational study was further... -
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