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Actin Engine in Immunological Synapse

Piragyte I, Jun CD

T cell activation and function require physical contact with antigen presenting cells at a specialized junctional structure known as the immunological synapse. Once formed, the immunological synapse leads to sustained...
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Requirement of CD4 Help for Induction of CD8 T Cell Response Specific for Virally Derived H60

Ryu SJ, Kang B, Kim SH, Kim TW, Chang J, Choi EY

CD40-CD40L-mediated help from CD4 T cells is essential to induce primary CD8 T cell responses specific to the non-inflammatory cell-based antigen H60. In this study, using H60 as a model...
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Kinetic Analysis of CpG-Induced Mouse B Cell Growth and Ig Production

Kim YH, Lee SH, Yoo YC, Lee J, Park JH, Park SR

Immune cells express toll-like receptors (TLRs) and respond to molecular patterns of various pathogens. CpG motif in bacterial DNA activates innate and acquired immune systems through binding to TLR9 of...
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Lactoferrin Stimulates Mouse Macrophage to Express BAFF via Smad3 Pathway

Chang H, Jin BR, Jang YS, Kim WS, Kim PH

B cell-activating factor belonging to the TNF family (BAFF) is primarily expressed by macrophages and stimulates B cell proliferation, differentiation, survival, and Ig production. In this study, we explored the...
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A Case of Drug-Induced Hepatitis due to Bortezomib in Multiple Myeloma

Kim Y, Kim KY, Lee SH, Chung YY, Yahng SA, Lee SE, Park G, Min CK

We report on a case of severe hepatotoxicity in a 52-year-old male with multiple myeloma (MM) who had received bortezomib therapy. At patient presentation, liver enzymes were normal, but started...
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Induction of Functional Changes of Dendritic Cells by Silica Nanoparticles

Kang K, Lim JS

Silica is one of the most abundant compounds found in nature. Immoderate exposure to crystalline silica has been linked to pulmonary disease and crystalline silica has been classified as a...
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Apoptosis of Human Islet Cells by Cytokines

Kim S, Kim KA, Suk K, Kim YH, Oh SH, Lee MK, Kim KW, Lee MS

FasL, perforin, TNFalpha, IL-1 and NO have been considered as effector molecule(s) leading to beta-cell death in autoimmune diabetes. However, the real culprit(s) of beta-cell destruction have long been elusive...
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Dietary Aloe QDM Complex Reduces Obesity-Induced Insulin Resistance and Adipogenesis in Obese Mice Fed a High-Fat Diet

Shin S, Kim S, Oh HE, Kong H, Shin E, Do SG, Jo TH, Park YI, Lee CK, Kim K

Obesity-induced disorders contribute to the development of metabolic diseases such as insulin resistance, fatty liver diseases, and type 2 diabetes (T2D). In this study, we evaluated whether the Aloe QDM...
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