- Membrane transducing activity of recombinant Hoxc8 protein and its possible application as a gene delivery vector
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Kim ES, Kang M, Park HW, Kim MH
- KMID: 1052937
- Exp Mol Med.
- 2008 Apr;40(2):151-160.
- doi: 10.3858/emm.2008.40.2.151
In order to examine whether the Hoxc8 protein can deliver nucleic acid into mammalian cells, we designed several Hoxc8-derived recombinant proteins to be synthesized as glutathione S-transferase (GST) fused forms... -
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- p53 overexpression represses androgen-mediated induction of NKX3.1 in a prostate cancer cell line
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Jiang A, Yu C, Zhang P, Chen W, Liu W, Hu X, Zhang J
- KMID: 1115940
- Exp Mol Med.
- 2006 Dec;38(6):625-633.
Prostate cancer is a disease involving complicated multiple-gene alterations. Both NKX3.1 and p53 are related to prostate cancer and play crucial roles in prostate cancer progression. However, little is known... -
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- 5-azacytidine induces cardiac differentiation of P19 embryonic stem cells
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Choi SC, Yoon JH, Shim WJ, Ro YM, Lim DS
- KMID: 1103318
- Exp Mol Med.
- 2004 Dec;36(6):515-523.
The P19 embryonal carcinoma cell line is a useful model cells for studies on cardiac differentiation. However, its low efficacy of differentiation hampers its usefulness. We investigated the effect of... -
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- Identification of Novel Methylation Markers in Hepatocellular Carcinoma using a Methylation Array
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Shin SH, Kim BH, Jang JJ, Suh KS, Kang GH
- KMID: 1714035
- J Korean Med Sci.
- 2010 Aug;25(8):1152-1159.
- doi: 10.3346/jkms.2010.25.8.1152
Promoter CpG island hypermethylation has become recognized as an important mechanism for inactivating tumor suppressor genes or tumor-related genes in human cancers of various tissues. Gene inactivation in association with... -
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- Identification of a Novel Deletion Region in 3q29 Microdeletion Syndrome by Oligonucleotide Array Comparative Genomic Hybridization
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Seo EJ, Jun KR, Yoo HW, Yoo HK, Lee JO
- KMID: 1096822
- Korean J Lab Med.
- 2010 Feb;30(1):70-75.
- doi: 10.3343/kjlm.2010.30.1.70
BACKGROUND: The 3q29 microdeletion syndrome is a genomic disorder characterized by mental retardation, developmental delay, microcephaly, and slight facial dysmorphism. In most cases, the microdeletion spans a 1.6-Mb region between... -
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- Clathrin Assembly Lymphoid Myeloid Leukemia-AF10-positive Acute Leukemias: A Report of 2 Cases with a Review of the Literature
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Huh JY, Chung S, Oh D, Kang MS, Eom HS, Cho EH, Han MH, Kong SY
- KMID: 1096795
- Korean J Lab Med.
- 2010 Apr;30(2):117-121.
- doi: 10.3343/kjlm.2010.30.2.117
The translocation t(10;11)(p13;q14q21) has been found to be recurrent in acute lymphoblastic and myeloid leukemias, and results in the fusion of the clathrin assembly lymphoid myeloid leukemia (CALM) gene with... -
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- Cyclooxygenase-2 Expression Is Related to the Epithelial-to-Mesenchymal Transition in Human Colon Cancers
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Jang TJ, Jeon KH, Jung KH
- KMID: 1777097
- Yonsei Med J.
- 2009 Dec;50(6):818-824.
- doi: 10.3349/ymj.2009.50.6.818
PURPOSE: Down-regulation of E-cadherin is a hallmark of the epithelial-to-mesenchymal transition (EMT). EMT progression in cancer cells is associated with the loss of certain epithelial markers and the acquisition of... -
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- Endothelial progenitor cell transplantation decreases lymphangiogenesis and adverse myocardial remodeling in a mouse model of acute myocardial infarction
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Park JH, Yoon JY, Ko SM, Jin SA, Kim JH, Cho CH, Kim JM, Lee JH, Choi SW, Seong IW, Jeong JO
- KMID: 1022123
- Exp Mol Med.
- 2011 Aug;43(8):479-485.
- doi: 10.3858/emm.2011.43.8.054
Cardiac lymphatic system in the remodeling after acute myocardial infarction (AMI) has been overlooked. We wanted to investigate the role of bone marrow-derived endothelial progenitor cells (EPCs) and their contribution... -
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- Candidate gene polymorphisms for diabetes mellitus, cardiovascular disease and cancer are associated with longevity in Koreans
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Park JW, Ji YI, Choi YH, Kang MY, Jung E, Cho SY, Cho HY, Kang BK, Joung YS, Kim DH, Park SC, Park J
- KMID: 1122278
- Exp Mol Med.
- 2009 Nov;41(11):772-781.
- doi: 10.3858/emm.2009.41.11.083
Long-lived people may have a unique genetic makeup that makes them more resistant than the general population to prevalent age-related diseases; however, not much is known about genes involved in... -
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- Alterations of proliferative and differentiation potentials of human embryonic stem cells during long-term culture
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Park YB, Kim YY, Oh SK, Chung SG, Ku SY, Kim SH, Choi YM, Moon SY
- KMID: 1103593
- Exp Mol Med.
- 2008 Feb;40(1):98-108.
- doi: 10.3858/emm.2008.40.1.98
Human embryonic stem cells (hESCs) are considered to be able to stably maintain their characteristics in vitro for prolonged periods, but we had previously encountered changes in proliferative ability and... -
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- Nickel induces secretion of IFN-gamma by splenic natural killer cells
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Kim JY, Huh K, Lee KY, Yang JM, Kim TJ
- KMID: 1088604
- Exp Mol Med.
- 2009 Apr;41(4):288-295.
- doi: 10.3858/emm.2009.41.4.032
Although nickel hypersensitivity is known as a delayed-type hypersensitivity mediated by nickel-specific T cells, it is greatly influenced by other immune cells. Here we show that splenic natural killer cells... -
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