- Membrane transducing activity of recombinant Hoxc8 protein and its possible application as a gene delivery vector
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Kim ES, Kang M, Park HW, Kim MH
- KMID: 1052937
- Exp Mol Med.
- 2008 Apr;40(2):151-160.
- doi: 10.3858/emm.2008.40.2.151
In order to examine whether the Hoxc8 protein can deliver nucleic acid into mammalian cells, we designed several Hoxc8-derived recombinant proteins to be synthesized as glutathione S-transferase (GST) fused forms... -
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- Identification of a putative transactivation domain in human Nanog
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Oh JH, Do HJ, Yang HM, Moon SY, Cha KY, Chung HM, Kim JH
- KMID: 1056238
- Exp Mol Med.
- 2005 Jun;37(3):250-254.
Nanog is a newly identified divergent homeodomain protein that directs the infinite propagation and sustains the pluripotency of embryonic stem cells. It has been reported that murine Nanog has two... -
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- Novel c.300_301delinsT Mutation in PITX2 in a Korean Family with Axenfeld-Rieger Syndrome
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Yun JW, Cho HK, Oh SY, Ki CS, Kee C
- KMID: 1781343
- Ann Lab Med.
- 2013 Sep;33(5):360-363.
- doi: 10.3343/alm.2013.33.5.360
Axenfeld-Rieger syndrome (ARS) is characterized by anomalies of the anterior segment of the eye and systemic abnormalities. Mutations in the FOXC1 and PITX2 genes are underlying causes of ARS, but... -
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- Roles of Gli3 in the Establishment of Progenitor Domains of Developing Spinal Cord
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Oh SO, Bae SK, Yoon S, Baek SY, Kim BS, Kim JB
- KMID: 2030776
- Korean J Anat.
- 2005 Feb;38(1):93-102.
University Sonic hedgehog (Shh) signaling has been shown to play instructive roles in developing spinal cord. Depending on the Shh concentration gradient, different progenitor domains and ventral neurons are induced.... -
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- Association of Polymorphisms in the Vitamin D Receptor Promoter with Idiopathic Short Stature
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Choi SK, Park MS, Song JK, Yoon KS, Yoon KL, Shim KS
- KMID: 1793048
- J Korean Med Sci.
- 2013 Sep;28(9):1329-1333.
- doi: 10.3346/jkms.2013.28.9.1329
The genetic alterations of vitamin D receptor (VDR) are related with the growth of long bone. There were a lot of reports regarding an association of polymorphisms in the VDR... -
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- B-cell translocation gene 2 positively regulates GLP-1-stimulated insulin secretion via induction of PDX-1 in pancreatic beta-cells
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Hwang SL, Kwon O, Kim SG, Lee IK, Kim YD
- KMID: 2154244
- Exp Mol Med.
- 2013 May;45(5):e25.
Glucagon-like peptide-1 (GLP-1) is a potent glucoincretin hormone and an important agent for the treatment of type 2 diabetes. Here we demonstrate that B-cell translocation gene 2 (BTG2) is a... -
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- Utility of Thyroid Transcription Factor-1 and Cytokeratin 20 in Identifying the Origin of Metastatic Carcinomas of Cervical Lymph Nodes
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Roh MS, Hong SH
- KMID: 1109761
- J Korean Med Sci.
- 2002 Aug;17(4):512-517.
- doi: 10.3346/jkms.2002.17.4.512
The identification of primary location of a metastatic tumor is a difficult diagnostic problem and sometimes can be facilitated by the use of immunohistochemical markers. Thyroid transcription factor-1 (TTF-1) is... -
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- A Family with Axenfeld-Rieger Syndrome: Report of the Clinical and Genetic Findings
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Yang HJ, Lee YK, Joo CK, Moon JI, Mok JW, Park MH
- KMID: 2363769
- Korean J Ophthalmol.
- 2015 Aug;29(4):249-255.
- doi: 10.3341/kjo.2015.29.4.249
PURPOSE: To describe clinical findings in a Korean family with Axenfeld-Rieger syndrome. METHODS: A retrospective review of clinical data about patients with diagnosed Axenfeld-Rieger syndrome. Five affected members of the family... -
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- Identification and functional characterization of an alternative splice variant within the fourth exon of human nanog
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Kim JS, Kim J, Kim BS, Chung HY, Lee YY, Park CS, Lee YS, Lee YH, Chung IY
- KMID: 1116205
- Exp Mol Med.
- 2005 Dec;37(6):601-607.
Nanog, a homeodomain (HD) transcription factor, plays a critical role in the maintenance of embryonic stem (ES) cell self-renewal. Here, we report the identification of an alternatively-spliced variant of nanog.... -
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- 5-azacytidine induces cardiac differentiation of P19 embryonic stem cells
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Choi SC, Yoon JH, Shim WJ, Ro YM, Lim DS
- KMID: 1103318
- Exp Mol Med.
- 2004 Dec;36(6):515-523.
The P19 embryonal carcinoma cell line is a useful model cells for studies on cardiac differentiation. However, its low efficacy of differentiation hampers its usefulness. We investigated the effect of... -
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- Transcriptional regulation of Zic3 by heterodimeric AP-1(c-Jun/c-Fos) during Xenopus development
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Lee SY, Lee HS, Moon JS, Kim JI, Park JB, Lee JY, Park MJ, Kim J
- KMID: 1123768
- Exp Mol Med.
- 2004 Oct;36(5):468-475.
The heterodimeric c-Jun/c-Fos, an activator protein-1 (AP-1) has been implicated in mesoderm induction (Dong et al., 1996; Kim et al., 1998) whereas the homodimer of c-Jun was reported to be... -
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- Gastrointestinal Metastasis from a Primary Adenocarcinoma of the Lung Presenting with Acute Abdominal Pain
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Hsing CT, Kim HY, Lee JH, Han JS, Lee JH, Chang JS, Choi SR, Jeong JS
- KMID: 1792839
- Korean J Gastroenterol.
- 2012 May;59(5):382-385.
- doi: 10.4166/kjg.2012.59.5.382
Symptomatic gastro-intestinal metastasis in lung cancer is extremely rare and only a few case reports have been published. Here, we report a case with lung adenocarcinoma that presented with acute... -
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- A Case of Congenital Central Hypoventilation Syndrome with PHOX2B Gene Mutation in a Korean Neonate
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Kwon KA, Park SE, Byun SY, Kim SY, Hwang SH
- KMID: 1714051
- J Korean Med Sci.
- 2010 Aug;25(8):1237-1240.
- doi: 10.3346/jkms.2010.25.8.1237
Congenital central hypoventilation syndrome (CCHS) is a life-threatening disorder with apnea and cyanosis during sleep requiring immediate endotracheal intubation during the first day of life. The PHOX2B gene has been... -
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- Circadian regulation of low density lipoprotein receptor promoter activity by CLOCK/BMAL1, Hes1 and Hes6
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Lee YJ, Han DH, Pak YK, Cho S
- KMID: 1401756
- Exp Mol Med.
- 2012 Nov;44(11):642-652.
Low density lipoprotein receptor (LDLR) plays an important role in the cholesterol homeostasis. We examined the possible circadian regulation of LDLR and mechanism(s) underlying it. In mice, blood glucose and... -
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- A Case of Hepatic Metastasis of Gastric Hepatoid Adenocarcinoma Mistaken for Primary Hepatocellular Carcinoma
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Moon JY, Kim GH, Cheong JH, Lee BE, Ryu DY, Song GA
- KMID: 1775812
- Korean J Gastroenterol.
- 2012 Oct;60(4):262-266.
- doi: 10.4166/kjg.2012.60.4.262
Gastric hepatoid adenocarcinoma is a special type of gastric carcinoma, which produces AFP. We report a case of an metastatic gastric hepatoid adenocarcinoma mistaken for primary hepatocellular carcinoma (HCC). A... -
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- Identification of Novel Methylation Markers in Hepatocellular Carcinoma using a Methylation Array
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Shin SH, Kim BH, Jang JJ, Suh KS, Kang GH
- KMID: 1714035
- J Korean Med Sci.
- 2010 Aug;25(8):1152-1159.
- doi: 10.3346/jkms.2010.25.8.1152
Promoter CpG island hypermethylation has become recognized as an important mechanism for inactivating tumor suppressor genes or tumor-related genes in human cancers of various tissues. Gene inactivation in association with... -
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- Haddad Syndrome with PHOX2B Gene Mutation in a Korean Infant
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Lee CW, Lee JH, Jung EY, Choi SO, Kim CS, Lee SL, Kim DK
- KMID: 1782126
- J Korean Med Sci.
- 2011 Feb;26(2):312-315.
- doi: 10.3346/jkms.2011.26.2.312
Congenital central hypoventilation syndrome with Hirschsprung's disease, also known as Haddad syndrome, is an extremely rare disorder with variable symptoms. Recent studies described that congenital central hypoventilation syndrome had deep... -
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- Clathrin Assembly Lymphoid Myeloid Leukemia-AF10-positive Acute Leukemias: A Report of 2 Cases with a Review of the Literature
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Huh JY, Chung S, Oh D, Kang MS, Eom HS, Cho EH, Han MH, Kong SY
- KMID: 1096795
- Korean J Lab Med.
- 2010 Apr;30(2):117-121.
- doi: 10.3343/kjlm.2010.30.2.117
The translocation t(10;11)(p13;q14q21) has been found to be recurrent in acute lymphoblastic and myeloid leukemias, and results in the fusion of the clathrin assembly lymphoid myeloid leukemia (CALM) gene with... -
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- p53 overexpression represses androgen-mediated induction of NKX3.1 in a prostate cancer cell line
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Jiang A, Yu C, Zhang P, Chen W, Liu W, Hu X, Zhang J
- KMID: 1115940
- Exp Mol Med.
- 2006 Dec;38(6):625-633.
Prostate cancer is a disease involving complicated multiple-gene alterations. Both NKX3.1 and p53 are related to prostate cancer and play crucial roles in prostate cancer progression. However, little is known... -
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- The Usefulness of CDX-2 for Differentiating Primary and Metastatic Ovarian Carcinoma: An Immunohistochemical Study Using a Tissue Microarray
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Kim MJ
- KMID: 1712747
- J Korean Med Sci.
- 2005 Aug;20(4):643-648.
- doi: 10.3346/jkms.2005.20.4.643
Distinguishing primary ovarian carcinoma from metastatic carcinoma to the ovary is often difficult by histologic examination alone. Recently an immunohistochemical marker CDX-2 was found to be of considerable diagnostic value... -
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