- Writing, erasing and reading histone lysine methylations
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Hyun K, Jeon J, Park K, Kim J
- KMID: 2382715
- Exp Mol Med.
- 2017 Apr;49(4):e324.
- doi: 10.1038/emm.2017.11
Histone modifications are key epigenetic regulatory features that have important roles in many cellular events. Lysine methylations mark various sites on the tail and globular domains of histones and their... -
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- Influence of Polycomb Proteins and Epigenetic Transcriptional Modifiers on the Development and Activation of T Lymphocytes
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Chun T
- KMID: 2168218
- Hanyang Med Rev.
- 2013 Feb;33(1):33-38.
- doi: 10.7599/hmr.2013.33.1.33
Transcriptional regulation of a gene is not always correlated with genetic information inherited from parents because the transcription of specific genes is often governed by the modification of chromatin structure.... -
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- Epigenetics: A key paradigm in reproductive health
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Bunkar N, Pathak N, Lohiya NK, Mishra PK
- KMID: 2308892
- Clin Exp Reprod Med.
- 2016 Jun;43(2):59-81.
- doi: 10.5653/cerm.2016.43.2.59
It is well established that there is a heritable element of susceptibility to chronic human ailments, yet there is compelling evidence that some components of such heritability are transmitted through... -
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- Histone Deacetylase-3 Modification of MicroRNA-31 Promotes Cell Proliferation and Aerobic Glycolysis in Breast Cancer and Is Predictive of Poor Prognosis
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Zhao Y, He J, Yang L, Luo Q, Liu Z
- KMID: 2413929
- J Breast Cancer.
- 2018 Jun;21(2):112-123.
- doi: 10.4048/jbc.2018.21.2.112
PURPOSE: The incidence and mortality of breast cancer is increasing worldwide. There is a constant quest to understand the underlying molecular biology of breast cancer so as to plan better... -
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- Epigenetic Modification in Systemic Rheumatic Diseases
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Lee J, Kim HR, Lee SH, Kim HY
- KMID: 2222752
- J Rheum Dis.
- 2013 Jun;20(3):140-148.
- doi: 10.4078/jrd.2013.20.3.140
Epigenetics is defined as an inheritable effect that influences gene activity, but does not involve a change in DNA sequence. Epigenetic gene regulation has an essential role in determining individual... -
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- The Epigenetics of Triple-Negative and Basal-Like Breast Cancer: Current Knowledge
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Temian DC, Pop LA, Irimie AI, Berindan-Neagoe I
- KMID: 2421363
- J Breast Cancer.
- 2018 Sep;21(3):233-243.
- doi: 10.4048/jbc.2018.21.e41
Breast cancer has the highest incidence among all malignancies diagnosed in women. Therapies have significantly improved over the years due to extensive molecular and clinical research; in a large number... -
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- Epigenetic biomarkers: a step forward for understanding periodontitis
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Lindroth A, Park YJ
- KMID: 1798484
- J Periodontal Implant Sci.
- 2013 Jun;43(3):111-120.
- doi: 10.5051/jpis.2013.43.3.111
Periodontitis is a common oral disease that is characterized by infection and inflammation of the tooth supporting tissues. While its incidence is highly associated with outgrowth of the pathogenic microbiome,... -
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- Epigenetic Role of Histone 3 Lysine Methyltransferase and Demethylase in Regulating Apoptosis Predicting the Recurrence of Atypical Meningioma
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Lee SH, Lee EH, Lee SH, Lee YM, Kim HD, Kim YZ
- KMID: 2164512
- J Korean Med Sci.
- 2015 Aug;30(8):1157-1166.
- doi: 10.3346/jkms.2015.30.8.1157
Alteration of apoptosis is related with progression and recurrence of atypical meningiomas (AMs). However, no comprehensive study has been conducted regarding histone modification regulating apoptosis in AMs. This study aimed... -
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- Epigenetics of Male Fertility: Effects on Assisted Reproductive Techniques
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Giacone F, Cannarella R, Mongioì L, Alamo A, Condorelli RA, Calogero A, La Vignera S
- KMID: 2443230
- World J Mens Health.
- 2019 May;37(2):148-156.
- doi: 10.5534/wjmh.180071
During the last decades the study of male infertility and the introduction of the assisted reproductive techniques (ARTs) has allowed to understand that normal sperm parameters do not always predict... -
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- Enrichment of rare alleles within epigenetic chromatin marks in the first intron
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Jo SS, Choi SS
- KMID: 2447799
- Genomics Inform.
- 2019 Mar;17(1):e9.
- doi: 10.5808/GI.2019.17.1.e9
In previous studies, we demonstrated that some sites in the first intron likely regulate gene expression. In the present work, we sought to further confirm the functional relevance of first... -
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- Aberrant Epigenetic Modifications of LPHN2 Function as a Potential Cisplatin-Specific Biomarker for Human Gastrointestinal Cancer
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Jeon MS, Song SH, Yun J, Kang JY, Kim HP, Han SW, Kim TY
- KMID: 2454346
- Cancer Res Treat.
- 2016 Apr;48(2):676-686.
- doi: 10.4143/crt.2015.153
PURPOSE: Epigenetic alterations of specific genes have recently been identified as diagnostic biomarkers for human cancers. However, there are currently no standardized epigenetic biomarkers for drug sensitivity in human gastrointestinal... -
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- RbAp48 expression and neuronal damage in the gerbil hippocampus following 5 min of transient ischemia
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Park JH, Lee TK, Kim DW, Park CW, Park YE, Kim B, Lee JC, Lee HA, Won MH, Ahn JH
- KMID: 2470111
- Lab Anim Res.
- 2019 Aug;35(2):78-85.
- doi: 10.1186/s42826-019-0011-3
Histone-binding protein RbAp48 has been known to be involved in histone acetylation, and epigenetic alterations of histone modifications are closely associated with the pathogenesis of ischemic reperfusion injury. In the... -
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- Epigenetics and Depression: An Update
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Lin E, Tsai SJ
- KMID: 2459685
- Psychiatry Investig.
- 2019 Sep;16(9):654-661.
- doi: 10.30773/pi.2019.07.17.2
OBJECTIVE: Depression is associated with various environmental risk factors such as stress, childhood maltreatment experiences, and stressful life events. Current approaches to assess the pathophysiology of depression, such as epigenetics... -
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- Epigenetic Changes in Asthma: Role of DNA CpG Methylation
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Bae DJ, Jun JA, Chang HS, Park JS, Park CS
- KMID: 2466615
- Tuberc Respir Dis.
- 2020 Jan;83(1):1-13.
- doi: 10.4046/trd.2018.0088
For the past three decades, more than a thousand of genetic studies have been performed to find out the genetic variants responsible for the risk of asthma. Until now, all... -
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