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Heat shock protein 70 increases cell proliferation, neuroblast differentiation, and the phosphorylation of CREB in the hippocampus

Kwon HJ, Kim W, Jung HY, Kang MS, Kim JW, Hahn KR, Yoo DY, Yoon YS, Hwang IK, Kim DW

In the present study, we investigated the effects of heat shock protein 70 (HSP70) on novel object recognition, cell proliferation, and neuroblast differentiation in the hippocampus. To facilitate penetration into...
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MicroRNA-16 inhibits cell proliferation and migration by targeting heat shock protein 70 in heat-denatured dermal fibroblasts

Zhang C, Dai J, Fan Y, He X, Wei R

BACKGROUND/AIMS: This study aimed to investigate the precise mechanism and function of miR-16 in heat-denatured primary human dermal fibroblasts. METHODS: Primary human dermal fibroblasts were separated from normal human skin samples....
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S100ß, Matrix Metalloproteinase-9, D-dimer, and Heat Shock Protein 70 Are Serologic Biomarkers of Acute Cerebral Infarction in a Mouse Model of Transient MCA Occlusion

Choi JI, Ha SK, Lim DJ, Kim SD, Kim SH

OBJECTIVE: Diagnosing acute cerebral infarction is crucial in determining prognosis of stroke patients. Although many serologic tests for prompt diagnosis are available, the clinical application of serologic tests is currently...
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Serial Changes of Heat Shock Protein 70 and Interleukin-8 in Burn Blister Fluid

Yoo K, Suh KY, Choi GH, Kwak IS, Seo DK, Kym D, Yoon H, Cho YS, Kim HO

BACKGROUND: It has been reported that heat shock protein 70 (HSP70) and interleukin-8 (IL-8) play an important role in cells during the wound healing process. However, there has been no...
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The Cytotoxicity of Kahweol in HT-29 Human Colorectal Cancer Cells Is Mediated by Apoptosis and Suppression of Heat Shock Protein 70 Expression

Choi DW, Lim MS, Lee JW, Chun W, Lee SH, Nam YH, Park JM, Choi DH, Kang CD, Lee SJ, Park SC

Although coffee is known to have antioxidant, anti-inflammatory, and antitumor properties, there have been few reports about the effect and mechanism of coffee compounds in colorectal cancer. Heat shock proteins...
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The expression of FAS-associated factor 1 and heat shock protein 70 in ovarian cancer

Kang HJ, Moon HS, Chung HW

OBJECTIVE: In this study, we evaluated the expression of FAS-associated factor 1 (FAF1) and heat shock protein 70 (HSP70) in normal ovary and ovarian cancer, and also analyzed the correlation...
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Possible Implications of Placental Expressions for Heat Shock Protein 70 and Lectin-like Oxidized Low Density Lipoprotein Receptor-1 on Postnatal Blood Pressure in Their Newborns

Choi SY, Ahn YM, Min JW, Park HS, Kim YJ, Park EA, Ha EH, Lee HY

  • KMID: 2283410
  • Korean J Phys Anthropol.
  • 2007 Sep;20(3):189-199.
The 'fetal origin' hypothesis propose the alteration in fetal environment result in developmental adaptation, the permanently change in structure, physiology and metabolism, thereby predisposing to cardiovascular, metabolic and endocrine disease...
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p53, Heat Shock Protein 70 and Topoisomerase II Expression in Gallbladder Carcinoma

Kim DC, Roh MS, Jeong JS

  • KMID: 1593780
  • Korean J Pathol.
  • 2006 Dec;40(6):432-438.
BACKGROUND: The present study was designed to investigate the expression of p53, Heat Shock Protein 70 (HSP70), and Topoisomerase (Topo) II alpha in the preneoplastic lesions and carcinomas of the...
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Effect of the Heat Shock Protein 70 on the Adjuvanticity Induced by a Bacterial Flagellin of Vibrio ulnificus

Lee SE, Bae SJ, Kim SY, Kim YR, Rhee JH

  • KMID: 1574182
  • J Bacteriol Virol.
  • 2005 Dec;35(4):299-306.
Recently we have shown that a bacterial flagellin, Vibrio vulnifiucs FlaB (Vv-FlaB), has a strong adjuvant activity to induce protective immune response. In order to investigate the adjuvanticity of Vv-FlaB,...
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Effects of Heat Shock Protein 70 (HSP70) Induction after Lipopoly?saccharide Exposure on the IL-6 Production and the Cell Viability after Subsequent Lipopolysaccharide Challenge in Murine Alveolar Epithelial Cells

Lee JM, Kim JS, Kim YK, Kim SJ, Lee SY, Kwon SS, Park SH

  • KMID: 2318550
  • Tuberc Respir Dis.
  • 2005 Apr;58(4):375-384.
BACKGROUND AND AIMS: Pre-induction of heat shock protein 70 (HSP70) is known to effectively attenuate the lipopolysaccharide (LPS)-induced inflammatory response in lung tissue. However, it is unclear if HSP70 induction...
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Protective Efficacy of Recombinant Proteins Adenylate Kinase, Nucleoside Diphosphate Kinase, and Heat-Shock Protein 70 against Mycobacterium tuberculosis Infection in Mice

Lee SH, Lee EG, Kim SY, Cho SN, Park YK, Bai GH

  • KMID: 2318536
  • Tuberc Respir Dis.
  • 2005 Feb;58(2):142-151.
BACKGROUND: Priming and boosting vaccination strategy has been widely explored for new vaccine development against tuberculosis. As an effort to identify other vaccine candidates, this study was initiated to evaluate...
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The Study about Expression and Regulation Mechanism of Heat Shock Protein 70 by Arisostatins A in Caki Cell Line of Renal Cell Carcinoma

Lee H, Kwon TK, Park JW, Lee KS

  • KMID: 2293956
  • Korean J Urol.
  • 2005 Feb;46(2):181-189.
PURPOSE: The events of cell stress and cell death are linked, with the heat shock proteins (Hsps) induced in response to stress appearing to function at key regulatory points in...
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Heat-Shock Protein 70 Attenuates Caspase-3 Activation and DNA Fragmentation Following Focal Cerebral Ischemia

Lee SH, Kwon HM, Kim YJ, Lee KM, Kim M, Yoon BW

  • KMID: 2343115
  • J Korean Neurol Assoc.
  • 2004 Dec;22(6):623-630.
BACKGROUND: Recently, HSP70 has been shown to act as an inhibitor of apoptotic pathways in the cell culture following heat shock; however, little information is available on the mechanism of...
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Effect of Etomidate on the Expressions of c-JUN and Heat Shock Protein 70 Induced by Kainic Acid in Rats

Lee JH, Lee YM, Chang BJ, Park SJ, Lee JY, Kim JU, Ku SW

BACKGROUND: The present investigation was undertaken to evaluate the neuroprotective effect of etomidate against kainic acid (KA) induced neurotoxicity in rats by Western immunoblotting for heat shock protein 70 (HSP-70),...
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Fluoxetine Pretreatment Exert Time-Dependent Inhibits the Dexamethasone-Mediated Heat Shock Protein 70 Expression in Rat C6 Glioma Cells

Lee JS, Yang BH, Kim SH, Choi MR, Chai YG

  • KMID: 2286877
  • Korean J Psychopharmacol.
  • 2004 Mar;15(1):66-74.
OBJECTIVE: The aim of this study was to examine the effect of dexamethasone and fluoxetine on the expression of 70 kDa heat shock protein (HSP70) in C6 glioma cells. METHODS:...
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Effects of Temperature Change on Heat Shock Protein 70 Expression in Rat Testes

Park SH, Park K, Park YI

  • KMID: 2293759
  • Korean J Urol.
  • 2003 Feb;44(2):186-191.
PURPOSE: It has been reported that exposure of the testes to elevated temperatures results in decreased spermatogenesis. The aim of this study was to investigate the effects of temperature change...
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Expression of Heat Shock Protein 70 in Ipsilateral Rat Kidney with Unilateral Partial Ureteral Obstruction

Jeong WJ, Song KH, Kim KJ

  • KMID: 2292526
  • Korean J Urol.
  • 2002 Dec;43(12):1065-1069.
PURPOSE: A partial ureteral obstruction is a common clinical finding. Heat shock proteins (HSPs) maintain homeostasis, and protect cells from various injuries caused by physical and biochemical stresses. Particularly, heat...
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The Role of Heat Shock Protein 70 in the Pancreatic Trypsinogen Activation: Studies in Hsp70.1 Knock-out Mice

Hwang JH, Kim YT, Yoon YB, Jeong JB, Bae CJ, Seo JS, Kim CY

  • KMID: 1647238
  • Korean J Gastroenterol.
  • 2002 Nov;40(5):326-333.
BACKGROUND/AIMS: Heat shock proteins (Hsps) are expressed in the cell as a response to the external stimulation such as heat. There are some reports that the Hsp (i.e. Hsp70) is...
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Association of Heat Shock Protein 70 Gene Polymorphisms with Schizophrenia

Kim JJ, Lee KU, Lee SJ, Kwon OJ, Lee CU, Lee C, Paik IH, Han JH

  • KMID: 2340757
  • J Korean Neuropsychiatr Assoc.
  • 2002 Sep;41(5):814-822.
OBJECTIVES: Contemporary understanding of schizophrenia has evolved over the last century, yet its pathogenesis is not clear. Environmental stresses in early gestational period, which in turn, can cause neurodevelopmental abnormalities,...
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Induction of Heat Shock Protein 70 after Experimental Pulpal Exposure in Rats

Baik JW, Baek SH, Yoon TG, Kim HJ, Yum KW

BACKGROUND: Inducible heat shock protein 70s (iHSP70) are expressed by stressful stimuli that result in protein denaturation, and are thought to assist in the maintenance of cellular integrity and...
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