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The Evolutionary Medicine of Birth Decision: Psycho-Socio-Ecological Explanations

Ryou J, Gu J, Park H

A key factor in evolution is reproduction, which is also a major concern in medicine. Evolutionists have proposed many theories and hypotheses to explain the low fertility rates of modern...
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The Prevalence of Dementia in Patients with Hansen's Disease in a Sanatorium of Korea

Lee CS, Kang HS, Gu J, Park CS, Shon JW, Kim BJ

  • KMID: 2334062
  • J Korean Geriatr Psychiatry.
  • 2007 Dec;11(2):104-108.
OBJECTIVES: To identify prevalence of dementia and it's subtypes in patients with Hansen's disease in a sanatorium of Korea. METHODS: The study employs a two-stage design for case identification. One hundred-six...
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Influence of Blood Coagulation Factors on Thromboelastographic Parameters in Healthy Adults

Kim S, Kim MJ, Gu J, Kim HK

Background: Thromboelastography (TEG) is a method that assesses whole-blood coagulation efficiency by measuring different parameters of clot formation and clot lysis. Whether and how blood coagulation factors influence the TEG...
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The Level of Performance, Frequency and Educational Needs of Nursing Activities in Long-term Care Hospital

Moon SS, Suh YO, Lee KW, Gu J

PURPOSE: This study was to explore the level of core nursing activities performed by long-term care hospital nurses and to investigate the frequency and educational needs of major nursing activities. METHODS:...
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Involvement of the Ca2+ signaling pathway in osteoprotegerin inhibition of osteoclast differentiation and maturation

Fu Y, Gu J, Wang Y, Yuan Y, Liu X, Bian J, Liu ZP

The purpose of this study was to determine whether the Ca2+ signaling pathway is involved in the ability of osteoprotegerin (OPG) to inhibit osteoclast differentiation and maturation. RAW264.7 cells were...
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Cadmium induces apoptosis in primary rat osteoblasts through caspase and mitogen-activated protein kinase pathways

Zhao H, Liu W, Wang Y, Dai N, Gu J, Yuan Y, Liu X, Bian J, Liu ZP

Exposure to cadmium (Cd) induces apoptosis in osteoblasts (OBs); however, little information is available regarding the specific mechanisms of Cd-induced primary rat OB apoptosis. In this study, Cd reduced cell...
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Gap junction blockage promotes cadmium-induced apoptosis in BRL 3A derived from Buffalo rat liver cells

Hu D, Zou H, Han T, Xie J, Dai N, Zhuo L, Gu J, Bian J, Yuan Y, Liu X, Liu Z

Gap junctions mediate direct communication between cells; however, toxicological cascade triggered by nonessential metals can abrogate cellular signaling mediated by gap junctions. Although cadmium (Cd) is known to induce apoptosis...
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Single-Cell Landscape and a Macrophage Subset Enhancing Brown Adipocyte Function in Diabetes

Gu J, Jin J, Ren X, Zhang X, Li J, Wang X, Zhang S, Yin X, Zhang Q, Wang Z

Background: Metabolic dysregulation is a hallmark of type 2 diabetes mellitus (T2DM), in which the abnormalities in brown adipose tissue (BAT) play important roles. However, the cellular composition and function...
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Chronic stress enhances progression of periodontitis via alpha1-adrenergic signaling: a potential target for periodontal disease therapy

Lu H, Xu M, Wang F, Liu S, Gu J, Lin S

This study assessed the roles of chronic stress (CS) in the stimulation of the sympathetic nervous system and explored the underlying mechanisms of periodontitis. Using an animal model of periodontitis...
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Chronic stress accelerates ligature-induced periodontitis by suppressing glucocorticoid receptor-α signaling

Lu H, Xu M, Wang F, Liu S, Gu J, Lin S, Zhao L

Periodontitis is a common chronic inflammatory disease. Recent studies have shown that chronic stress (CS) might modulate periodontal disease, but there are few models of CS-induced periodontitis, and the underlying...
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Preeclampsia serum-induced collagen I expression and intracellular calcium levels in arterial smooth muscle cells are mediated by the PLC-gamma1 pathway

Jiang R, Teng Y, Huang Y, Gu J, Ma L, Li M, Zhou Y

In women with preeclampsia (PE), endothelial cell (EC) dysfunction can lead to altered secretion of paracrine factors that induce peripheral vasoconstriction and proteinuria. This study examined the hypothesis that PE...
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Comparison of Liver Transplantation and Liver Resection for Hepatocellular Carcinoma Patients with Portal Vein Tumor Thrombus Type I and Type II

Lv JY, Zhang NN, Du YW, Wu Y, Song TQ, Zhang YM, Qu Y, Liu YX, Gu J, Wang ZY, Qiu YB, Yang B, Tian DZ, Guo QJ, Zhang L, Sun JS, Xie Y, Wang ZL, Sun X, Jiang WT, Lu W

Purpose: The aim of this study was to compare the efficacy of liver transplantation (LT) and liver resection (LR) for hepatocellular carcinoma (HCC) patients with portal vein tumor thrombus (PVTT)...
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