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Alterations in Serum BDNF and GDNF Levels after 12 Weeks of Antidepressant Treatment in Female Outpatients with Major Depressive Disorder

Park YM, Lee BH

OBJECTIVE: Some clinical studies have found alterations in the levels of serum brain-derived neurotrophic factor (BDNF) and glial cell line-derived neurotrophic factor (GDNF) after applying antidepressant treatment in patients with...
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Expression of mRNAs for Neurotrophic Factors in Human Neural Stem Cells Derived from Fetal Telencephalon

Yoo YM, Lee U, Kim YJ

  • KMID: 2188881
  • J Korean Neurosurg Soc.
  • 2003 May;33(5):488-494.
OBJECTIVE: Cellular diversity in the mammalian central nervous system is originated from precursor cells present in the neural ectoderm. The multipotent neural stem cells(NSCs) rapidly proliferate to give rise to...
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Analysis of Histopathological Findings of Hirschsprung's Disease: Immunohistochemical Studies Including GDNF and Cathepsin D

Koo H, Choi KJ

No abstract available in English.
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Effect of Platelet Rich Plasma on Facial Nerve Regeneration in Acute Nerve Injury Model

Cho HH, Lee SC, Jang SJ, Kim SH, Jeong HS, Park JS, Han JY, Lee KH, Cho YB

BACKGROUND AND OBJECTIVES: The object of this study was to evaluate the effect of platelet rich plasma (PRP) on facial nerve regeneration from an axotomy injury in the guinea pig...
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Hirschsprung's Disease: Etiology and Pathophysiology

Lee MD

  • KMID: 1961648
  • J Korean Assoc Pediatr Surg.
  • 2002 Jun;8(1):41-47.
Abnormal distribution of the enteric nerves such as adrenergic, cholinergic and peptidergic nerves may cause the functional obstruction in Hirschsprung's disease (HD). Although the sustained contraction of the aganglionic segment...
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Effects of nerve cells and adhesion molecules on nerve conduit for peripheral nerve regeneration

Chung JR, Choi JW, Fiorellini JP, Hwang KG, Park CJ

BACKGROUND: For peripheral nerve regeneration, recent attentions have been paid to the nerve conduits made by tissue-engineering technique. Three major elements of tissue-engineering are cells, molecules, and scaffolds. METHODS: In this...
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Naringin: A Protector of the Nigrostriatal Dopaminergic Projection

Jung UJ, Leem E, Kim SR

Parkinson's disease is the second most common neurodegenerative disorder characterized by the progressive degeneration of dopaminergic neurons and a biochemical reduction of striatal dopamine levels. Despite the lack of fully...
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Expression of Neural Cell Adhesion Molecule (NCAM) and Glial Cell Line-Derived Neurotrophic Factor (GDNF) in Aganglionic Bowel of Hirschsprung's Disease

Oh JT, Han A, Son SW, Choi SH, Han SJ, Hwang EH, Yang WI

  • KMID: 2427286
  • J Korean Assoc Pediatr Surg.
  • 2001 Jun;7(1):15-20.
The pathophysiology of Hirschsprung's disease (HD) is not fully understood, but recent studies have disclosed that neural cell adhesion molecule (NCAM) and glial cell line-derived neurotrophic factor (GDNF) play important...
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Altered Plasma Levels of Glial Cell Line-Derived Neurotrophic Factor in Patients with Internet Gaming Disorder: A Case-Control, Pilot Study

Jeong JE, Paik SH, Choi MR, Cho H, Choi JS, Choi SW, Kim DJ

Glial cell line-derived neurotrophic factor (GDNF) has been reported to be involved in negatively regulating the effects of addictive disorders. The objective of this study was to investigate alterations in...
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The Association between Korean Schizophrenics and GDNF Gene Polymorphism

Kim KY, Kim JW, Lee HJ, Cho AR, Chang HI

  • KMID: 2287336
  • Korean J Psychopharmacol.
  • 2003 Sep;14(3):259-266.
OBJECTIVE: The association of neurotrophic factors with the etiology of schizophrenia has been widely studied. Among them, glial cell line-derived neurotrophic factor (GDNF) is known to promote the survival and...
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Effects of Fetal Mesencephalic Cell Grafts on the Intrastriatal 6-hydroxydoapmine Lesioned Rats

Joo WS, Nam E, Im HI, Jung JA, Lee ES, Hwang YJ, Kim YS

  • KMID: 1611426
  • Korean J Physiol Pharmacol.
  • 2004 Oct;8(5):245-251.
The effects of fetal mesencephalic cell grafts on the restoration of nigrostriatal dopaminergic function were studied in the intrastriatal 6-hydroxydopamine-lesioned rats. Four weeks after lesioning, transplantation of ventral mesencephalic cells...
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Epigenetic Regulation in the Brain after Spinal Cord Injury : A Comparative Study

Park BN, Kim SW, Cho SR, Lee JY, Lee YH, Kim SH

OBJECTIVE: After spinal cord injury (SCI), functional and structural reorganization occurs at multiple levels of brain including motor cortex. However, the underlying mechanism still remains unclear. The current study was...
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The Effect of Transfection of RET9 and RET51 on Apoptosis in SW48 and RKO Colon Cancer Cells

Seo HI, Park DI

BACKGROUND/AIMS: Dependent receptor can transmit both positive signal: proliferation, differentiation or migration; and negative signal: apoptosis. It depends on the presence of its ligand. This study was performed to determine...
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Effect of Antenatal Dexamethasone Treatment on Neuronal Morphogenesis

Yoon SJ, Koo H, Kim CI

  • KMID: 2275424
  • Korean J Pathol.
  • 2005 Apr;39(2):81-90.
BACKGROUND: Glucocorticoids (GCs) are essential for normal development and the maturation of the central nervous system. The aim of this study was to determine the effects of antenatal dexamethasone (DEXA)...
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Effects of Calcitriol on Delayed Neuronal Damage of Hippocampus in Transient Global Ischemia Model of Mature Gerbil

Park HJ, Koo HS, Han WS, Choi KK

  • KMID: 2275533
  • Korean J Pathol.
  • 2003 Oct;37(5):307-315.
BACKGROUND: It is well documented that calcium ions perform a major role in neuronal degeneration in cerebrovascular disease and the other degenerative diseases, and that 1,25-dihydroxyvitamin D3 (D3) has the...
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L-NAME, a Non Selective Nitric Oxide Synthase, Affects Stress-Related Behaviors and Glial Cell-Derived Neurotrophic Factor Expression in Restrained Adolescent ICR Mice

Kwon KJ, Byun JS, Lee JW, Chun W, Kim SS, Lee HJ

  • KMID: 2287475
  • Korean J Psychopharmacol.
  • 2012 Jan;23(1):5-10.
OBJECTIVE: Depending on genetic or environmental effects over adolescent development, typical behavioral responses come out in adolescence. Also, alteration of nitric oxide (NO) levels in the brain has been associated...
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Effect of Growth Factors on Hearing Restoration in Deafened Animal Model

Kim JH, Park SN, Yeo SW, Kim YH, Jin SY, Kim JH, Cho SJ, Kim JH, Choi MY, Park KH

  • KMID: 2276966
  • Korean J Otorhinolaryngol-Head Neck Surg.
  • 2008 Dec;51(12):1093-1098.
BACKGROUND AND OBJECTIVES: Sensorineural hearing loss is caused by ototoxic drugs, radiation therapy, noise exposure and trauma, etc. They make irreversible changes in cochlear hair cells and degeneration of spiral...
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The Modulation of Neurotrophin and Epigenetic Regulators: Implication for Astrocyte Proliferation and Neuronal Cell Apoptosis After Spinal Cord Injury

Kim JH, Kim SH, Cho SR, Lee JY, Kim JH, Baek A, Jung HS

OBJECTIVE: To investigate alterations in the expression of the main regulators of neuronal survival and death related to astrocytes and neuronal cells in the brain in a mouse model of...
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Variations of Neurotrophic Factors and It's Importances in Spinal Cord Injured Rats and Beagle Dogs

Song IS, Yang JY, Lee JK, Joo YB, Cha SM

STUDY DESIGN: Experimental, prospective study OBJECTIVES: To examine the changes in the variable factors after an acute spinal cord injury(SCI) in rats and dogs simultaneously. SUMMARY OF LITERATURE REVIEW: No study has...
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Glial Cell Line-derived Neurotrophic Factor-overexpressing Human Neural Stem/Progenitor Cells Enhance Therapeutic Efficiency in Rat with Traumatic Spinal Cord Injury

Hwang K, Jung K, Kim IS, Kim M, Han J, Lim J, Shin JE, Jang JH, Park KI

Spinal cord injury (SCI) causes axonal damage and demyelination, neural cell death, and comprehensive tissue loss, resulting in devastating neurological dysfunction. Neural stem/progenitor cell (NSPCs) transplantation provides therapeutic benefits for...
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