- Editor’s introduction to this issue (G&I 20:1, 2022)
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Park T
- KMID: 2527944
- Genomics Inform.
- 2022 Mar;20(1):e1.
- doi: 10.5808/gi.20.1.e1
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- Whole-genome sequence analysis through online web interfaces: a review
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Gunasekara AWACWR, Rajapaksha LGTG, Tung T
- KMID: 2527946
- Genomics Inform.
- 2022 Mar;20(1):e3.
- doi: 10.5808/gi.20038
The recent development of whole-genome sequencing technologies paved the way for understanding the genomes of microorganisms. Every whole-genome sequencing (WGS) project requires a considerable cost and a massive effort to... -
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- MPI-GWAS: a supercomputing-aided permutation approach for genome-wide association studies
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Paik H, Cho Y, Cho SB, Kwon OK
- KMID: 2527957
- Genomics Inform.
- 2022 Mar;20(1):e14.
- doi: 10.5808/gi.22001
Permutation testing is a robust and popular approach for significance testing in genomic research that has the advantage of reducing inflated type 1 error rates; however, its compu-tational cost is... -
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- Publication trends of somatic mutation and recombination tests research: a bibliometric analysis (1984‒2020)
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Tagorti G, Kaya B
- KMID: 2527953
- Genomics Inform.
- 2022 Mar;20(1):e10.
- doi: 10.5808/gi.21083
Human exposure to pollutants has been on the rise. Thus, researchers have been focused on understanding the effect of these compounds on human health, especially on the genetic information by... -
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- TcellInflamedDetector: an R package to distinguish T cell inflamed tumor types from non–T cell inflamed tumor types
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Yang SD, Park HS
- KMID: 2527956
- Genomics Inform.
- 2022 Mar;20(1):e13.
- doi: 10.5808/gi.22005
A major issue in the use of immune checkpoint inhibitors is their lack of efficacy in many patients. Previous studies have reported that the T cell inflamed signature can help... -
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- Bayesian mixed models for longitudinal genetic data: theory, concepts, and simulation studies
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Chung W, Cho Y
- KMID: 2527951
- Genomics Inform.
- 2022 Mar;20(1):e8.
- doi: 10.5808/gi.21080
Despite the success of recent genome-wide association studies (GWAS) investigating longitudinal traits, a large fraction of overall heritability remains unexplained. This suggests that some of the missing heritability may be... -
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- Exploration of errors in variance caused by using the first-order approximation in Mendelian randomization
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Kim H, Kim K, Han B
- KMID: 2527952
- Genomics Inform.
- 2022 Mar;20(1):e9.
- doi: 10.5808/gi.21060
Mendelian randomization (MR) uses genetic variation as a natural experiment to investigate the causal effects of modifiable risk factors (exposures) on outcomes. Two-sample Mendelian randomization (2SMR) is widely used to... -
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- Hypothetical protein predicted to be tumor suppressor: a protein functional analysis
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Kader MA, Ahammed A, Khan MS, Al Ashik SA, Islam MS, Hossain MU
- KMID: 2527949
- Genomics Inform.
- 2022 Mar;20(1):e6.
- doi: 10.5808/gi.21073
Litorilituus sediminis is a Gram-negative, aerobic, novel bacterium under the family of Colwelliaceae, has a stunning hypothetical protein containing domain called von Hippel-Lindau that has significant tumor suppressor activity. Therefore,... -
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- Presentation of potential genes and deleterious variants associated with non-syndromic hearing loss: a computational approach
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Ray M, Rath SN, Sarkar S, Sable MN
- KMID: 2527948
- Genomics Inform.
- 2022 Mar;20(1):e5.
- doi: 10.5808/gi.21070
Non-syndromic hearing loss (NSHL) is a common hereditary disorder. Both clinical and genetic heterogeneity has created many obstacles to understanding the causes of NSHL. The present study has attempted to... -
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- 2-Methoxy-1,4-naphthoquinone (MNQ) regulates cancer key genes of MAPK, PI3K, and NF-κB pathways in Raji cells
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Wong TY, Menaga S, Huang CYF, Ho SHA, Gan SC, Lim YM
- KMID: 2527950
- Genomics Inform.
- 2022 Mar;20(1):e7.
- doi: 10.5808/gi.21041
2-Methoxy-1,4-naphthoquinone (MNQ) has been shown to cause cytotoxic towards various cancer cell lines. This study is designed to investigate the regulatory effect of MNQ on the key cancer genes in... -
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- Experimental development of the epigenomic library construction method to elucidate the epigenetic diversity and causal relationship between epigenome and transcriptome at a single-cell level
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Park K, Jeon MC, Kim B, Cha B, Kim JI
- KMID: 2527945
- Genomics Inform.
- 2022 Mar;20(1):e2.
- doi: 10.5808/gi.21078
The method of single-cell RNA sequencing has been rapidly developed, and numerous experiments have been conducted over the past decade. Their results allow us to recognize various subpopulations and rare... -
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- Comparison of the copy-neutral loss of heterozygosity identified from whole-exome sequencing data using three different tools
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Lee GT, Chung YJ
- KMID: 2527947
- Genomics Inform.
- 2022 Mar;20(1):e4.
- doi: 10.5808/gi.21066
Loss of heterozygosity (LOH) is a genomic aberration. In some cases, LOH can be generated without changing the copy number, which is called copy-neutral LOH (CN-LOH). CN-LOH frequently occurs in... -
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- Designing a novel mRNA vaccine against Vibrio harveyi infection in fish: an immunoinformatics approach
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Islam SI, Mou MJ, Sanjida S, Tariq M, Nasir S, Mahfuj S
- KMID: 2527954
- Genomics Inform.
- 2022 Mar;20(1):e11.
- doi: 10.5808/gi.21065
Vibrio harveyi belongs to the Vibrio genus that causes vibriosis in marine and aquatic fish species through double-stranded DNA virus replication. In humans, around 12 Vibrio species can cause gastroenteritis... -
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- Characterization of the first mitogenomes of the smallest fish in the world, Paedocypris progenetica, from peat swamp of Peninsular Malaysia, Selangor, and Perak
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Hussin N, Azmir IA, Esa Y, Ahmad A, Salleh FM, Jahari PNS, Munian K, Gan HM
- KMID: 2527955
- Genomics Inform.
- 2022 Mar;20(1):e12.
- doi: 10.5808/gi.21081
The two complete mitochondrial genomes (mitogenomes) of Paedocypris progenetica, the smallest fish in the world which belonged to the Cyprinidae family, were sequenced and assembled. The circular DNA molecules of... -
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