- The Expression of p53, c-erbB-2 and nm23 Proteins in Breast Cancer
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Lee KY, Kim YG, Kim YS, Han KJ, Kang CS, Kim JA, Kim WI, Shim SI
- KMID: 1921777
- Korean J Pathol.
- 1999 Feb;33(2):88-95.
Recently, p53, c-erbB-2 and nm23 proteins have been studied in breast cancer. The expression of p53 protein indicates the mutation of p53 gene known as a tumor supressor gene, and... -
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- Amplification and Overexpression of c-erbB-2 in Gastric Cancer
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Jun SY, Chung HY, Lee SC, Huh TL, Yu W
- KMID: 2175010
- J Korean Cancer Assoc.
- 2000 Jun;32(3):467-475.
PURPOSE: We compared c-erbB-2 oncogene amplification and oncoprotein expression, trying to identify the biologic and prognostic significance of c-erbB-2 in adendegrees Carcinoma of the stomach. MATERIALS AND METHODS: Formalin-fixed, paraffin-embedded tissue sections... -
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- Prognostic Significance of Immunohistochemical Expression of EGFR and C-erbB-2 Oncoprotein in Curatively Resected Gastric Cancer
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Song HS, Do YR, Kim IH, Sohn SS, Kwon KY
- KMID: 2166138
- Cancer Res Treat.
- 2004 Aug;36(4):240-245.
PURPOSE: The purpose of this study was to investigate the prognostic significance of the expression of EGFR and C-erbB-2 gene products by immunohistochemical analysis for curatively resected gastric adenocarcinoma. MATERIALS... -
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- Correlation of EGFR and c-erbB-2 Gene Amplifications and Expression of COX-2 Protein in Invasive Ductal Carcinomas of the Breast
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Hong BK, Kim BG, Cha SJ, Park SJ, Lim HM, Lee TJ
- KMID: 2210202
- J Korean Surg Soc.
- 2005 Oct;69(4):279-285.
PURPOSE: Abnormalities of epidermal growth factor receptor (EGFR) and c-erbB-2 have been actively investigated in breast cancer. Cyclooxygenase-2 (COX-2) seems to be involved in critical steps of cancer onset and... -
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- An immunohistochemical demonstration of C-erbB-2 oncoprotein expression in prostatic adenocarcinoma
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Choi JB, Cheon J, Kim HK, Kim JJ, Ko SK
- KMID: 2289325
- Korean J Urol.
- 1993 Oct;34(5):764-769.
The c-erbB-2 gene is located on q21 of chromosome 17. The c-erbB-2 oncoprotein exhibits tyrosine kinase activity, appears to be a receptor for to yet unidentified growth factor and has... -
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- Expression of p53 and c-erbB-2 Proteins as a Prognostic Factor in Patients with Gastric Carcinomas
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Jeong EJ, Ha WS, Park ST, Lee YJ, Jong JY, Cho YH, Lee YJ, Jeong MH
- KMID: 1940350
- J Korean Surg Soc.
- 1998 May;54(5):649-661.
Gastric cancer is not only one of the most common cancers in the world but also one of the most important malignant tumors in terms of incidence in Korea. In... -
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- Clinical Significance of p53, c-erbB-2, Chromogranin A and PCNA in the Ampullary Carcinoma
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Kim KH, Kim SW, Kim WH, Park YH
- KMID: 2007131
- J Korean Cancer Assoc.
- 2001 Feb;33(1):84-91.
PURPOSE: To determine the clinical significance of p53, c-erbB-2, chromogranin A (CgA), proliferating cell nuclear antigen (PCNA) expression in ampullary carcinoma, a retrospective study was performed. MATERIALS AND METHODS: The cases... -
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- Immunohistochemical Characteristics of Biliary Tract Carcinoma and Its Precancerous Lesions
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Kim J, Park Y, Kim H
- KMID: 2011622
- Korean J Pathol.
- 1998 Nov;32(11):985-992.
Carcinomas of the biliary tract are known to be more common in East Asia than in Western countries, but their exact histopathological characteristics and tumorigenesis are not well elucidated. To... -
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- Clinicopathological Characteristics and Predictive Markers of Early Gastric Cancer with Recurrence
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Kim JW, Hwang I, Kim MJ, Jang SJ
- KMID: 1783148
- J Korean Med Sci.
- 2009 Dec;24(6):1158-1164.
- doi: 10.3346/jkms.2009.24.6.1158
Early gastric cancer (EGC) is a "curable" disease with a high cure rate made possible through proper surgical treatment; nonetheless, some patients sustain a disease recurrence after curative resection. The... -
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- Correlation of AR, EGFR, and HER2 Expression Levels in Prostate Cancer: Immunohistochemical Analysis and Chromogenic In Situ Hybridization
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Baek KH, Hong ME, Jung YY, Lee CH, Lee TJ, Park ES, Kim MK, Yoo JH, Lee SW
- KMID: 2167587
- Cancer Res Treat.
- 2012 Mar;44(1):50-56.
PURPOSE: The androgen receptor (AR) plays a central role in prostate cancer. Evidence from several groups indicates that epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2... -
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- The effect of isochromosome 17q presence, proliferative and apoptotic indices, expression of c-erbB-2, bcl-2 and p53 proteins on the prognosis of medulloblastoma
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Nam DH, Wang KC, Kim YM, Chi JG, Kim SK, Cho BK
- KMID: 1730644
- J Korean Med Sci.
- 2000 Aug;15(4):452-456.
- doi: 10.3346/jkms.2000.15.4.452
Medulloblastoma accounts for 20 to 25+ACU- of all intracranial neoplasms in children. The significance of the presence of isochromosome 17q (i(17q)), proliferative potential, apoptotic activity, and expression of c-erbB-2, bd-2,... -
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- Comparison of Silver-Enhanced in situ Hybridization and Fluorescence in situ Hybridization for HER2 Gene Status in Breast Carcinomas
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Kang J, Kwon GY, Lee YH, Gong G
- KMID: 2175512
- J Breast Cancer.
- 2009 Dec;12(4):235-240.
- doi: 10.4048/jbc.2009.12.4.235
PURPOSE: Silver-enhanced in situ hybridization (SISH) is a newly developed method to evaluate HER2 gene amplification in invasive breast carcinomas. Most laboratories widely use fluorescence in situ hybridization (FISH) to... -
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- Automated Silver-enhanced In Situ Hybridization for Evaluation of HER2 Gene Status in Breast Carcinoma: Comparison with Fluorescence In Situ Hybridization and Immunohistochemistry
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Sung WJ, Park SJ, Gu MJ, Bae YK
- KMID: 2277620
- Korean J Pathol.
- 2010 Feb;44(1):28-34.
BACKGROUND: The human epidermal growth factor receptor 2 (HER2) is amplified in 20-25% of breast cancers. HER2 overexpression or amplification is associated with a worse clinical outcome and it can... -
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- Prognostic Significance of HER2 Gene Amplification According to Stage of Breast Cancer
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Kim YS, Won YS, Park KS, Song BJ, Kim JS, Oh SJ, Jeon HM, Jung SS, Park WC
- KMID: 1786878
- J Korean Med Sci.
- 2008 Jun;23(3):414-420.
- doi: 10.3346/jkms.2008.23.3.414
It is well known that the amplification of the HER2 gene is closely associated with poor prognosis of breast cancer. However, there is controversy about the clinical significance of HER2... -
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- Role of Epidermal Growth Factor Receptor and the HER-2 Gene in Hormone Refractory Prostate Cancer
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Cho KS, Kim DJ, Lee JS, Cho NH, Park K, Ham WS, Choi YD
- KMID: 2312032
- Korean J Urol.
- 2008 Jan;49(1):24-30.
PURPOSE: Amplification and mutation of the epidermal growth factor receptor(EGFR) and HER-2 genes were analyzed in the tissues of hormone refractory prostate cancer(HRPC) patients. MATERIALS AND METHODS: Gene amplifications of the... -
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- HER-2/neu Oncogene Amplification by Chromogenic in situ Hybridization in 130 Breast Cancers Using Tissue Microarray and Clinical Follow-up Studies
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Chang E, Lee A, Lee E, Lee H, Shin O, Oh S, Kang C
- KMID: 1786817
- J Korean Med Sci.
- 2004 Jun;19(3):390-396.
- doi: 10.3346/jkms.2004.19.3.390
Determining of HER-2/neu oncogene amplification has become clinically important for managing breast cancer. Fluorescent in situ hybridization (FISH) and immunohistochemistry (IHC) are currently regarded as the standard methods. Chromogenic in... -
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- Multiplication of Chromosome 17 Centromere Is Associated with Prognosis in Patients with Invasive Breast Cancers Exhibiting Normal HER2 and TOP2A Status
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Kim A, Shin HC, Bae YK, Kim MK, Kang SH, Lee SJ, Lee EH
- KMID: 2286470
- J Breast Cancer.
- 2012 Mar;15(1):24-33.
- doi: 10.4048/jbc.2012.15.1.24
PURPOSE: This study aimed to investigate the clinical significance of chromosome 17 centromere (CEP17) multiplication (increased copy number of CEP17) related to human epidermal growth factor receptor 2 (HER2) and... -
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- HER2 Status by Standardized Immunohistochemistry and Silver-Enhanced In Situ Hybridization in Korean Breast Cancer
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Bae YK, Gong G, Kang J, Lee A, Cho EY, Lee JS, Suh KS, Lee DW, Jung WH, The Breast Pathology Study Group of Korean Society of Pathologists
- KMID: 2286433
- J Breast Cancer.
- 2012 Dec;15(4):381-387.
- doi: 10.4048/jbc.2012.15.4.381
PURPOSE: Amplification of the human epidermal growth factor receptor 2 (HER2) gene occurs in 18% to 20% of breast cancers, and it is recognized as a prognostic and predictive marker.... -
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- Gene Expression Profiles of Primary Breast Cancer Tissue Using cDNA Microarray
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Han W, Chung KW, Ahn SJ, Noh DY, Youn YK, Oh SK, Choe KJ
- KMID: 2059062
- J Korean Breast Cancer Soc.
- 2002 Dec;5(4):284-290.
- doi: 10.4048/jkbcs.2002.5.4.284
PURPOSE: Breast cancer is characterized by an extensive heterogeneity that complicates the precise assessment of tumor aggressiveness and makes therapeutic decisions difficult. Variation in transcriptional programs accounts for much of... -
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- The Prognostic and Predictive Value of EGFR and HER-2 in Advanced Non-small Cell Lung Cancer Patients Who Are Treated with Cisplatin and Paclitaxel
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Yoo J, Shim BY, Kang SJ
- KMID: 1464705
- J Lung Cancer.
- 2009 Jun;8(1):13-20.
- doi: 10.6058/jlc.2009.8.1.13
PURPOSE: Although both platinum-based drugs and third-generation drugs are commonly used as first-line therapy for patients with advanced, unresectable non-small cell lung cancer, their effectiveness and clinical outcomes vary. We... -
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