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Fibroblast Growth Factor 21: A Novel Metabolic Regulator

Seo JA, Kim NH

No abstract available.
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Pfeiffer Syndrome Type 2 with Sporadic Fibroblast Growth Factor Receptor 2 Mutation and Coccygeal Anomaly

Lee JS, Choi JH, Lee YW, Gang MH, You SK, Shin HD, Chang MY

Pfeiffer syndrome is a rare genetic disorder characterized by premature fusion of certain skull bones (craniosynostosis) and anomalies of the face and extremities. A female newborn showing ocular proptosis and...
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A case of Apert's Syndrome(Acrocophalosyndactyly) with Fibroblast Growth Factor Receptor 2 Exon IIIa Mutation

Kim HS, Yang PS, Kang JY, Kim OY, Ku CH, Lee WM

  • KMID: 2335506
  • J Korean Pediatr Soc.
  • 2000 Jul;43(7):1006-1011.
Apert syndrome is an uncommon congenital disorder characterized by malformation of the skull in association with symmetrical syndactyly of both hands and feet. This syndrome is autosornal dominant. The original description was...
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Transcriptional Regulation of Fibroblast Growth Factor 21 Expression

Bae KH, Kim JG, Park KG

Fibroblast growth factor 21 (FGF21) is an attractive target for treating metabolic disease due to its wide-ranging beneficial effects on glucose and lipid metabolism. Circulating FGF21 levels are increased in...
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Mutation at exon 10 of the fibroblast growth factor receptor 3 (FGFR3) in a fetus with thanatophoric dysplasia type I (TDI)

Yang WK, Park WI, Ko DS, Kim SH, Kim EK, Lee HJ

  • KMID: 2261540
  • Korean J Obstet Gynecol.
  • 1999 Oct;42(10):2214-2220.
Thanatophoric dysplasia (TD) is a sporadic lethal type of skeletal dysplasia featuring micromelia, decreased thoracic dimension and macrocephaly. To date, several kinds of mutation in fibroblast growth factor receptor 3...
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Expression of Fibroblast Growth Factor Receptor 3 in the Recurrence of Non-Muscle-Invasive Urothelial Carcinoma of the Bladder

Maeng YH, Eun SY, Huh JS

  • KMID: 2314806
  • Korean J Urol.
  • 2010 Feb;51(2):94-100.
PURPOSE: The fibroblast growth factor receptor 3 (FGFR3) gene is known to be frequently mutated in noninvasive urothelial carcinomas of the bladder. In this study, we investigated the expression of...
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Mutation Analysis in Fibroblast Growth Factor Receptor 3 Gene in Korean Children with Simple Craniosynostosis

Park B, Son D, Kim D, Han K

  • KMID: 2144764
  • J Korean Soc Plast Reconstr Surg.
  • 2001 Nov;28(6):637-640.
The C749G(Pro250Arg) mutation in the gene for fibroblast growth factor receptor 3 (FGFR3) has been found in patients with various types of craniosynostosis. In this study, the blood of 9...
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Effect of bFGF on the MCF-7 Cell Cycle with CD44+/CD24-: Promoting the G0/G1-->G2/S Transition

Yang ZL, Cheng K, Han ZD

PURPOSE: Few cells with stem cell characteristics possess capabilities of self-renewal and differentiation, which leads to high tumorigenesis and resistance to standard chemotherapeutic agents. These cells are mostly quiescent, and...
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bFGF & FGFR Expression in Chronic Airway Remodeling of Asthma

Yum HY

  • KMID: 2314418
  • Pediatr Allergy Respir Dis.
  • 2006 Dec;16(4):267-273.
A number of structural changes occur in the airway wall in asthma. The most characteristic is thickening of the subepithelial lamina reticularis which is observed in bronchial tissue even in...
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Effects on Myoblast Proliferation by Fibroblast Growth Factor, Leukemia Inhibitory Factor and Interleukin-1

Park YG

  • KMID: 2136615
  • J Korean Acad Rehabil Med.
  • 2002 Aug;26(4):426-431.
OBJECTIVE: Recently, cultured myoblast transplantation has been extensively studied as a gene complementation approach in such genetic diseases as Duchenne muscular dystrophy (DMD). In the present work we investigated the...
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Difference of Fibroblast Growth Factor Receptor-1(FGFR-1) and Progesterone Receptor(PR) Expression between Classic and Aggressive Meningiomas

Cho TH, Park JY, Chai YS, Park YK, Chung YG, Chung HS, Lee HK, Lee KC

  • KMID: 2018898
  • J Korean Neurosurg Soc.
  • 1996 Aug;25(8):1555-1560.
Fibroblast growth factor(FGF) is a mitogen and a potent antigenic factor. It is also known as a differentiation factor for neuroectodermal-derived cell. It has been observed to be expressed in...
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Hepatokines as a Link between Obesity and Cardiovascular Diseases

Yoo HJ, Choi KM

Non-alcoholic fatty liver disease, which is considered a hepatic manifestation of metabolic syndrome, independently increases the risks of developing cardiovascular disease (CVD) and type 2 diabetes mellitus. Recent emerging evidence...
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Fibroblast Growth Factor 21 Mimetics for Treating Atherosclerosis

Kwok KH, Lam KS

Fibroblast growth factor 21 (FGF21) is an atypical member of the FGF family. Acting in an endocrine fashion, it increases glucose uptake, modulates lipid metabolism, and sensitizes insulin response in...
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Moleculobiological Analysis of Fibroblast Growth Factor Receptors in Korean Patients with Craniosynostosis

Lee JH, Tark MS, Lee YM, Kim YB

  • KMID: 1961951
  • J Korean Cleft Palate-Craniofac Assoc.
  • 2002 Apr;3(1):45-49.
Fibroblast growth factor(FGF) play a critical role in bone growth and development, affecting both chondrogenesis and osteogenesis. The authors believe, many craniosynostosis disorders to be linked with activating mutations in...
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Expression of growth factor, extracellular matrix and antioxidant (N-acetylcysteine) effect in TGF beta1 treated rat lens system

Park MS, Ahn CS, Hong YS

  • KMID: 2206311
  • J Korean Ophthalmol Soc.
  • 2002 Dec;43(12):2543-2554.
PURPOSE: The objective of this study was to characterize transdifferentiated lens epithelial cells analyzed by reverse transcription-polymerase chain reaction (RT-PCR) for the expression of mRNAs encoding growth factors, growth factor...
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Association Study of Fibroblast Growth Factor 2 and Fibroblast Growth Factor Receptors Gene Polymorphism in Korean Ossification of the Posterior Longitudinal Ligament Patients

Jun JK, Kim SM

OBJECTIVE: The aim of this study was to determine whether single nucleotide polymorphisms (SNPs) of fibroblast growth factor (FGF) 2 gene and fibroblast growth factor receptor (FGFR) genes are associated...
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Expression of the mRNA of Growth Factor Receptors and Neurotrophic Factors in Porcine Vesical Submucosa and Acellular Matrix

Moon HC, Joo KJ, Park HJ

  • KMID: 2293814
  • Korean J Urol.
  • 2005 Dec;46(12):1344-1347.
PURPOSE: Several naturally-derived biopolymers have been introduced as implantable biomaterial for tissue reconstruction, and some of them are already being applied in various clinical fields. They serve as backbones for...
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Ga68-DOTA Peptide PET/CT to Detect Occult Mesenchymal Tumor-Inducing Osteomalacia: A Case Series of Three Patients

Ho CL

Tumor-induced osteomalacia (TIO) is a rare disease that manifests with paraneoplasic syndrome and overproduction of fibroblast growth factor 23 (FGF23), leading to renal phosphate wasting and hyperphosphaturia, eventually leading to...
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Zerumbone, Sesquiterpene Photochemical from Ginger, Inhibits Angiogenesis

Park JH, Park GM, Kim JK

Here, we investigated the role of zerumbone, a natural cyclic sesquiterpene of Zingiber zerumbet Smith, on angiogenesis using human umbilical vein endothelial cells (HUVECs). Zerumbone inhibited HUVECs proliferation, migration and...
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A FGF23-Positive Maxillary Sinus Tumor Associated with Oncogenic Osteomalacia

Kim NH, Kim JH, Kwon JH, Kim KS

  • KMID: 2297584
  • J Rhinol.
  • 2012 May;19(1):70-73.
Oncogenic osteomalacia is a rare acquired paraneoplastic syndrome caused by excessive renal phosphate wasting that causes hypophosphatemia and osteomalacia. Fibroblast growth factor 23 (FGF23) has been identified as the causative...
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