Diabetes Metab J.  2015 Feb;39(1):10-15. 10.4093/dmj.2015.39.1.10.

Hepatokines as a Link between Obesity and Cardiovascular Diseases

• Yoo HJ
• Choi KM

• KMID: 2280651
• DOI: http://doi.org/10.4093/dmj.2015.39.1.10

Abstract

Non-alcoholic fatty liver disease, which is considered a hepatic manifestation of metabolic syndrome, independently increases the risks of developing cardiovascular disease (CVD) and type 2 diabetes mellitus. Recent emerging evidence suggests that a group of predominantly liver-derived proteins called hepatokines directly affect the progression of atherosclerosis by modulating endothelial dysfunction and infiltration of inflammatory cells into vessel walls. Here, we summarize the role of the representative hepatokines fibroblast growth factor 21, fetuin-A, and selenoprotein P in the progression of CVD.

Keyword

Fetuin-A; Fibroblast growth factor 21; Hepatokines; Non-alcoholic fatty liver disease; Selenoprotein P

MeSH Terms

alpha-2-HS-Glycoprotein
Atherosclerosis
Cardiovascular Diseases*
Diabetes Mellitus, Type 2
Fatty Liver
Fibroblast Growth Factors
Obesity*
Selenoprotein P
Fibroblast Growth Factors
Selenoprotein P
alpha-2-HS-Glycoprotein

Figure

• 

  Fig. 1 Underlying mechanism connecting non-alcoholic fatty liver disease (NAFLD) to cardiovascular disease (CVD). LDL, low density lipoprotein; HDL, high density lipoprotein; hsCRP, high-sensitivity C-reactive protein; PAI-1, plasminogen activator inhibitor-1; FGF-21, fibroblast growth factor 21.

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