- Lowering of plasma free fatty acids by acipimox increases insulin sensitivity in rats
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Lee KU, Suh KI, Park SW, Park KS, Lee HK, Min HK
- KMID: 1700045
- J Korean Diabetes Assoc.
- 1993 Mar;17(1):73-78.
No abstract available. -
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- Epidermal Lipid Homeostasis
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Lee SH, Chung HS, Lew W
- KMID: 2383065
- Ann Dermatol.
- 1995 Apr;7(2):99-111.
- doi: 10.5021/ad.1995.7.2.99
Stratum corneum lipids, which are enriched in sphingolipids, free fatty acids, and cholesterol, are required for epidermal barrier function. When the epidermal permeability barrier is perturbed, the transepidermal water loss... -
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- Ceramides: Nutrient Signals that Drive Hepatosteatosis
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Summers SA
- KMID: 2470800
- J Lipid Atheroscler.
- 2020 Jan;9(1):50-65.
- doi: 10.12997/jla.2020.9.1.50
Ceramides are minor components of the hepatic lipidome that have major effects on liver function. These products of lipid and protein metabolism accumulate when the energy needs of the hepatocyte... -
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- Acute Fatty Liver of Pregnancy Associated with Diabetes Insipidus
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Park JS, Kim H, Lee SW
- KMID: 2332763
- J Korean Soc Emerg Med.
- 2010 Jun;21(3):412-415.
Acute fatty liver of pregnancy (AFLP) is a rare but potentially fatal complication of pregnancy that occurs in the third trimester, and results in microvesicular fat deposition in the liver,... -
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- An Update on Hypertriglyceridemia-Induced Acute Pancreatitis
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Kim HJ
- KMID: 2438042
- Korean J Med.
- 2018 Dec;93(6):518-524.
- doi: 10.3904/kjm.2018.93.6.518
Hypertriglyceridemia a major cause of acute pancreatitis, accounting for up to 10% of all cases. The pathophysiological mechanism of hypertriglyceridemia-induced acute pancreatitis (HTGP) is presumed to involve the hydrolysis of... -
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- What is the Key Step in Muscle Fatty Acid Oxidation after Change of Plasma Free Fatty Acids Level in Rats?
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Doh KO, Suh SD, Kim JY
- KMID: 1600060
- Korean J Physiol Pharmacol.
- 2005 Jun;9(3):173-177.
The purpose of this study was to discern the critical point in skeletal muscle fatty acid oxidation by changing plasma free fatty acids (FFA) level in rat. In the study,... -
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- Mechanistic insights into pancreatic beta-cell mass regulation by glucose and free fatty acids
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Oh YS
- KMID: 2046071
- Anat Cell Biol.
- 2015 Mar;48(1):16-24.
- doi: 10.5115/acb.2015.48.1.16
Pancreatic islets are responsible for blood glucose homeostasis. Reduced numbers of functional (insulin-secreting) beta-cells in pancreatic islets underlies diabetes. Restoration of the secretion of the proper amount of insulin is... -
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- Recent update on pathogenesis of nonalcoholic fatty liver disease
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Sohn JH, Kim TY
- KMID: 1458413
- Korean J Med.
- 2010 Nov;79(5):461-474.
Recently, the prevalence of nonalcoholic fatty liver disease (NAFLD) is increasing in Korean population. NAFLD includes a spectrum of hepatic pathology from simple steatosis in its most benign form, to... -
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- Intercellular Lipid Mediators and GPCR Drug Discovery
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Im DS
- KMID: 2170658
- Biomol Ther.
- 2013 Nov;21(6):411-422.
G-protein-coupled receptors (GPCR) are the largest superfamily of receptors responsible for signaling between cells and tissues, and because they play important physiological roles in homeostasis, they are major drug targets.... -
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- The Progression of Liver Fibrosis in Non-alcoholic Fatty Liver Disease
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Kim MY
- KMID: 2384360
- Korean J Gastroenterol.
- 2017 Jun;69(6):341-347.
- doi: 10.4166/kjg.2017.69.6.341
Understanding the pathogenesis of non-alcoholic steatohepatitis (NASH) and its fibrosis progression is still evolving. Nonetheless, current evidence suggests that mechanisms involved are very complex parallel processes with multiple metabolic factors.... -
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- In Vitro Effect of Fatty Acids Identified in the Plasma of Obese Adolescents on the Function of Pancreatic β-Cells
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Velasquez , Vasquez JS, Balcazar N
- KMID: 2392471
- Diabetes Metab J.
- 2017 Aug;41(4):303-315.
- doi: 10.4093/dmj.2017.41.4.303
BACKGROUND: The increase in circulating free fatty acid (FFA) levels is a major factor that induces malfunction in pancreatic β-cells. We evaluated the effect of FFAs reconstituted according to the... -
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- Pathophysiology of Craniocerebal Trauma
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Kim HJ
- KMID: 2187600
- J Korean Neurosurg Soc.
- 1987 Dec;16(4):1183-1200.
The past decade witnessed a new and improved understanding of the incidence and pathophysiology of secondary central nervous system insults from hypoxia, arterial hypotension and ischemia allowing altered therapeutic approaches... -
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- Visceral Obesity
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Yoo HJ
- KMID: 2184900
- J Korean Med Assoc.
- 2007 Aug;50(8):725-728.
- doi: 10.5124/jkma.2007.50.8.725
Multiple lines of evidence support the thesis that visceral adiposity is causally related to insulin resistance and the metabolic syndrome. Visceral adipose tissue is biochemically quite distinct from subcutaneous adipose... -
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- Changes of Serum Fatty Acid and Carnitine Levels after Administration of L-carnitine in Rats
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Lee JW, Hong YM
- KMID: 2207171
- J Korean Pediatr Soc.
- 2002 Sep;45(9):1075-1082.
PURPOSE: Obesity is known to be associated with hypertension, dyslipidemia, and fatty liver and is thought to be associated with increased levels of free fatty acids. One of the strategies... -
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- Role of miR-511 in the Regulation of OATP1B1 Expression by Free Fatty Acid
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Peng JF, Liu L, Guo CX, Liu SK, Chen XP, Huang LH, Xiang H, Huang ZJ, Yuan H, Yang GP
- KMID: 2380287
- Biomol Ther.
- 2015 Sep;23(5):400-406.
- doi: 10.4062/biomolther.2015.010
MicroRNAs (miRNAs) are a family of non-coding RNA that are able to adjust the expression of many proteins, including ATP-binding cassette transporter and organic cation transporter. We sought to evaluate... -
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- Differential Effects of Palmitate and Docosahexaenoic acid on ATP-sensitive K+ Channel Activity of Pancreatic beta-cells
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Kim YW, Doh KO, Song DK, Bae JH, Park WK, Won KJ, Lee HW, Lee SK
- KMID: 2063349
- J Korean Diabetes Assoc.
- 1999 Dec;23(6):768-776.
BACKGROUND: Elevated levels of free fatty acids markedly enhance insulin secretion. However, dietary polyunsaturated fatty supplementation decrease insulin secretion. The effects of different type of fatty acids on cultured pancreatic... -
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- Evaluation of Expression of Lipases and Phospholipases of Malassezia restricta in Patients with Seborrheic Dermatitis
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Lee YW, Lee SY, Lee Y, Jung WH
- KMID: 2265870
- Ann Dermatol.
- 2013 Aug;25(3):310-314.
- doi: 10.5021/ad.2013.25.3.310
BACKGROUND: Malassezia species (spp.) are cutaneous opportunistic pathogens and associated with various dermatological diseases including seborrheic dermatitis, dandruff and atopic dermatitis. Almost all Malassezia spp. are obligatorily lipid-dependent, which might... -
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- Ultrasonographic ovarian dynamic, plasma progesterone, and non-esterified fatty acids in lame postpartum dairy cows
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Melendez P, Gomez V, Bothe H, Rodriguez , Velez J, Lopez H, Bartolome , Archbald L
- KMID: 2412137
- J Vet Sci.
- 2018 May;19(3):462-467.
- doi: 10.4142/jvs.2018.19.3.462
The objective of this study was to compare ovulation rate, number of large ovarian follicles, and concentrations of plasma progesterone (P4) and non-esterified fatty acids (NEFA) between lame (n =... -
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- A Study on the Serum Concentrations of Lipoproteins and Lipids in Preeclampsia
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Cho YK, Park KH, Min HJ, Choi H, Kim BR, Lee HK
- KMID: 2072002
- Korean J Perinatol.
- 1999 Dec;10(4):478-484.
OBJECTIVE: To determine whether there is correlation between serum concentrations of lipoproteins (VLDL, HDL, LDL) and development of preedampsia. METHODS: The authors measured serum concentrations of lipoproteins(VLDL, HDL, LDL) and... -
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- Role of phospholipase A2 in hypoxia-induced renal cell injury
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Choi WR, Ko SH, Cho SI, Woo JS, Jung JS, Lee SH, Kim YK
- KMID: 1917075
- Korean J Physiol Pharmacol.
- 1999 Feb;3(1):93-100.
The present study was designed to assess the roles of PLA2 activation and arachidonic acid (AA) metabolites in hypoxia-induced renal cell injury. Hypoxia increased LDH release in a dose-dependent manner in rabbit renal... -
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