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Comparative Analysis of the Tear Protein Expression After Photorefractive Keratectomy Using Two-Dimensional Electrophoresis

Chae JK, Park SP, Choi TH

PURPOSE:To investigate the change in the tear protein composition of patients who underwent refractive surgery. METHODS: Tear samples were collected before photorefrative keratectomy (PRK), on the first, the second, and the...
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Mechanisms Underlying Trabecular Meshwork Cell Death Caused by Mutant Myocilin Expression

Lim DH, Sohn S, Kim TE, Kee C

PURPOSE: To determine whether the expression of mutant myocilin can lead to death of human trabecular meshwork (HTM) cells and to determine whether the mechanism by which this occurs is...
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Maturation-Resistant Dendritic Cells Ameliorate Experimental Autoimmune Uveoretinitis

Oh K, Kim YS, Lee DS

BACKGROUND: Endogenous uveitis is a chronic inflammatory eye disease of human, which frequently leads to blindness. Experimental autoimmune uveoretinitis (EAU) is an animal disease model of human endogenous uveitis and...
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Detection of specific proteins in the aqueous humor in primary open-angle glaucoma

Lee IS, Yu YS, Kim DM, Youn DH, Kim JQ

To elucidate the mechanism of increased intraocular pressure in primary open-angle glaucoma (POAG), the protein profiles of aqueous humor obtained from POAG patients were compared with those of cataract patients...
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Stimulation of macrophage function by interphotoreceptor retinoid-binding protein: production of nitric oxide

Bae SR

In this study, we investigated whether retinal soluble proteins, such as interphotoreceptor retinoid-binding protein(IRBP), play a role in the induction of nitric oxide by macrophages in vitro. Cells from the...
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Mutations of the Norrie gene in Korean ROP infants

Kim JH, Yu YS, Kim J, Park SS

The present study was conducted to evaluate if there is a Norrie disease gene (ND gene) mutation involved in the retinopathy of prematurity (ROP), and to identify the possibility of...
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TIGR gene in primary open-angle glaucoma and steroid-induced glaucoma

Kee C, Ahn BH

To identify TIGR gene mutation in two Korean pedigrees of primary open-angle glaucoma (POAG), and in 25 steroid-induced glaucoma patients, TIGR gene assay was performed. Genomic DNA was extracted from...
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A Case of 9.7 Mb Terminal Xp Deletion Including OA1 Locus Associated with Contiguous Gene Syndrome

Cho EH, Kim SY, Kim JK

Terminal or interstitial deletions of Xp (Xp22.2-->Xpter) in males have been recognized as a cause of contiguous gene syndromes showing variable association of apparently unrelated clinical manifestations such as Leri-Weill...
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Osteogenesis Imperfecta Type VI with Severe Bony Deformities Caused by Novel Compound Heterozygous Mutations in SERPINF1

Cho SY, Ki CS, Sohn YB, Kim SJ, Maeng SH, Jin DK

Osteogenesis imperfecta (OI) comprises a heterogeneous group of disorders characterized by bone fragility, frequent fractures, and low bone mass. Dominantly inherited COL1A1 or COL1A2 mutations appear to be causative in...
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Stimulation of macrophage function by S-antigen: production of nitric oxide

Bae SR

In this study, we investigated whether retinal soluble proteins, such as S-antigen, play a role in the induction of nitric oxide by macrophages in vitro. Cells from the murine macrophage...
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A Novel Mutation in the XLRS1 Gene in a Korean Family with X-linked Retinoschisis

Koh HJ, Jwa NS, Kim SS, Lee SC, Kwon OW

PURPOSE: To report a novel missense mutation in the XLRS1 gene in a Korean family with X-linked retinoschisis. METHODS: Observation case report of a family with a proband with...
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