- Mitogen-activated Protein Kinases in Inflammation
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Manzoor Z, Koh YS
- KMID: 1434747
- J Bacteriol Virol.
- 2012 Sep;42(3):189-195.
- doi: 10.4167/jbv.2012.42.3.189
Mitogen-activated protein kinases (MAPKs) play critical regulatory roles in the production of the pro-inflammatory cytokines and downstream signaling events which lead to inflammation. Inflammation is a primarily localized and protective... -
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- A Role of Mitogen Activated Protein Kinases and Inflammatory Responses in Gender Differences in Kidney Ischemia Injury
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Park KM, Han HJ
- KMID: 2285245
- Korean J Physiol Pharmacol.
- 2002 Jun;6(3):155-160.
It is not known whether gender differences play a role in susceptibility to ischemic acute renal failure. Thus, we examined if there were any differences in susceptibility between male and... -
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- Various Wavelengths of Light-Emitting Diode Light Regulate the Proliferation of Human Dermal Papilla Cells and Hair Follicles via Wnt/β-Catenin and the Extracellular Signal-Regulated Kinase Pathways
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Joo HJ, Jeong KH, Kim JE, Kang H
- KMID: 2395183
- Ann Dermatol.
- 2017 Dec;29(6):747-754.
- doi: 10.5021/ad.2017.29.6.747
BACKGROUND: The human dermal papilla cells (hDPCs) play an important role in regulation of hair cycling and growth. OBJECTIVE: The aim of this study was to investigate the effect of different... -
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- Curcumin Stimulates Proliferation of Spinal Cord Neural Progenitor Cells via a Mitogen-Activated Protein Kinase Signaling Pathway
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Son S, Kim KT, Cho DC, Kim HJ, Sung JK, Bae JS
- KMID: 2067068
- J Korean Neurosurg Soc.
- 2014 Jul;56(1):1-4.
- doi: 10.3340/jkns.2014.56.1.1
OBJECTIVE: The aims of our study are to evaluate the effect of curcumin on spinal cord neural progenitor cell (SC-NPC) proliferation and to clarify the mechanisms of mitogen-activated protein (MAP)... -
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- Sustained Intracellular Acidosis Triggers the Naâº/H⺠Exchager-1 Activation in Glutamate Excitotoxicity
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Lee BK, Jung YS
- KMID: 2395808
- Biomol Ther.
- 2017 Nov;25(6):593-598.
- doi: 10.4062/biomolther.2017.018
The Naâº/H⺠exchanger-1 (NHE-1) is a ubiquitously expressed pH-regulatory membrane protein that functions in the brain, heart, and other organs. It is increased by intracellular acidosis through the interaction of... -
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- Impaired Expression of MAPK Is Associated with the Downregulation of TNF-alpha, IL-6, and IL-10 in Mycobacterium abscessus Lung Disease
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Sim YS, Kim SY, Kim EJ, Shin SJ, Koh WJ
- KMID: 2319798
- Tuberc Respir Dis.
- 2012 Mar;72(3):275-283.
BACKGROUND: Healthy individuals who develop nontuberculous mycobacteria (NTM) lung disease are likely to have specific susceptibility factors which can lead to a NTM infection. The aim of the present study... -
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- Phytoestrogen-Induced Phosphorylation of MAP Kinase in Osteoblasts is Mediated by Membrane Estrogen Receptor
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Park YH, Park HK, Lee HJ, Park SM, Choi SW, Lee WJ
- KMID: 2285247
- Korean J Physiol Pharmacol.
- 2002 Jun;6(3):165-170.
We have previously demonstrated that phytoestrogens isolated from safflower seeds significantly attenuated bone loss in ovariectomized rats, and directly stimulated proliferation and differentiation of cultured osteoblastic cells. In an attempt... -
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- Immunohistochemical Study of the Expression of pERK1/2 Protein in the Forebrains of Adult Rodents Following Hypoxia-ischemia injury
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Han YJ, Ahn HC, Park JH, Yoo SJ
- KMID: 2332438
- J Korean Soc Emerg Med.
- 2008 Jun;19(3):313-321.
PURPOSE: The purpose of this study was to evaluate spatiotemporal evaluation of pERK1/2 protein expression in the forebrain following hypoxic-ischemic (HI) injury in adult Sprague-Dawley rats. METHODS: HI injury was induced... -
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- Effect of Caffeic Acid Phenethyl Ester on Lipopolysaccharide-induced Murine Macrophage Activation
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Lee SH, Li M, Lee DW, Lim DY, Jeong CW, Kwak SH
- KMID: 2228089
- Korean J Crit Care Med.
- 2011 Sep;26(3):134-138.
- doi: 10.4266/kjccm.2011.26.3.134
BACKGROUND: Caffeic acid phenethyl ester (CAPE) is an active component of propolis and is known to have anti-inflammatory properties. This study was performed to evaluate the effects of CAPE on... -
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- The effect of estrogen on extracellular signal-regulated kinases activation in uterine artery smooth muscle cells during pregnancy
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Lee YW, Kim HY, Park SM, Choi SR, Chung JY, Moon CS
- KMID: 2274074
- Korean J Obstet Gynecol.
- 2011 Sep;54(9):499-507.
- doi: 10.5468/KJOG.2011.54.9.499
OBJECTIVE: To explore the endothelium-independent mechanisms of estrogen induced uterine vasodilatation, this study was performed to determine whether uterine artery smooth muscle (UASM) cells are direct targets of estrogen, and... -
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- Effect of manassantin B, a lignan isolated from Saururus chinensis, on lipopolysaccharide-induced interleukin-1beta in RAW 264.7 cells
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Park HC, Bae HB, Jeong CW, Lee SH, Jeung HJ, Kwak SH
- KMID: 2236296
- Korean J Anesthesiol.
- 2012 Feb;62(2):161-165.
- doi: 10.4097/kjae.2012.62.2.161
BACKGROUND: Elevated systemic levels of pro-inflammatory cytokines cause hypotension during septic shock and induce capillary leakage in acute lung injury. Manassantin B has anti-inflammatory and anti-plasmoidal properties. This study examined... -
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- Dexamethasone Inhibits Interleukin-1beta-Induced Matrix Metalloproteinase-9 Expression in Cochlear Cells
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Nam SI, Kwon TK
- KMID: 1973466
- Clin Exp Otorhinolaryngol.
- 2014 Sep;7(3):175-180.
- doi: 10.3342/ceo.2014.7.3.175
OBJECTIVES: To investigate the effect of interleukin (IL)-1beta on matrix metalloproteinase (MMP)-9 expression in cochlea and regulation of IL-1beta-mediated MMP-9 expression by dexamethasone and the molecular and signaling mechanisms involved. METHODS:... -
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- Aldosterone-induced TGF-beta1 Expression is Regulated by Mitogen-Activated Protein Kinases and Activator Protein-1 in Mesangial Cells
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Han JS, Cho BS, Yang CW, Kim YS
- KMID: 1778162
- J Korean Med Sci.
- 2009 Jan;24(Suppl 1):S195-S203.
- doi: 10.3346/jkms.2009.24.S1.S195
Aldosterone has been shown to stimulate renal TGF-beta1 expression. However, the mechanisms for aldosterone-induced TGF-beta1 expression have not been clearly determined in mesangial cells. We examined the role of extracellular-signal... -
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- Suppression of CD81 promotes bladder cancer cell invasion through increased matrix metalloproteinase expression via extracellular signal-regulated kinase phosphorylation
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Park HS, Lee S, Lee J, Shin HB, Yoo SM, Lee MS, Park J
- KMID: 2455968
- Investig Clin Urol.
- 2019 Sep;60(5):396-404.
- doi: 10.4111/icu.2019.60.5.396
PURPOSE: CD81 is a prognostic biomarker for high-grade bladder cancer (BC). In this study, we aimed to determine the functional mechanisms underlying the role of CD81 in BC progression. MATERIALS AND... -
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- Galangin Activates the ERK/AKT-Driven Nrf2 Signaling Pathway to Increase the Level of Reduced Glutathione in Human Keratinocytes
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Hewage SR, Piao MJ, Kang KA, Ryu YS, Fernando P, Oh MC, Park JE, Shilnikova K, Moon YJ, Shin DO, Hyun JW
- KMID: 2386910
- Biomol Ther.
- 2017 Jul;25(4):427-433.
- doi: 10.4062/biomolther.2016.112
Previously, we demonstrated that galangin (3,5,7-trihydroxyflavone) protects human keratinocytes against ultraviolet B (UVB)-induced oxidative damage. In this study, we investigated the effect of galangin on induction of antioxidant enzymes involved... -
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- Lobaric Acid Inhibits VCAM-1 Expression in TNF-alpha-Stimulated Vascular Smooth Muscle Cells via Modulation of NF-kappaB and MAPK Signaling Pathways
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Kwon IS, Yim JH, Lee HK, Pyo S
- KMID: 2170537
- Biomol Ther.
- 2016 Jan;24(1):25-32.
- doi: 10.4062/biomolther.2015.084
Lichens have been known to possess multiple biological activities, including anti-proliferative and anti-inflammatory activities. Vascular cell adhesion molecule-1 (VCAM-1) may play a role in the development of atherosclerosis. Hence, VCAM-1... -
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- The Effects of Extracellular pH on Proliferation and Differentiation of human Bone Marrow Stem Cells
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Leem YH, Nam TS, Kim JH, Lee KS, Lee DH, Yun J, Chang JS
- KMID: 1464234
- Korean J Bone Metab.
- 2012 May;19(1):35-46.
- doi: 10.11005/kjbm.2012.19.1.35
OBJECTIVES: The purpose of this study is to identify whether the change of pH affects the proliferation and the differentiation of human bone marrow stem cells (hBMSCs) and what mechanism... -
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- Kappa-opioid receptor activation during reperfusion limits myocardial infarction via ERK1/2 activation in isolated rat hearts
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Kim JH, Jang YH, Chun KJ, Kim J, Park YH, Kim JS, Kim JM, Lee MY
- KMID: 1780180
- Korean J Anesthesiol.
- 2011 May;60(5):351-356.
- doi: 10.4097/kjae.2011.60.5.351
BACKGROUND: We investigated whether p42/p44 extracellular signal-regulated kinases (ERK1/2) and/or phosphatidylinositol-3-OH kinase (PI3K)-Akt play a crucial role in cardioprotection by kappa-opioid receptor (KOP) activation. METHODS: Langendorff perfused rat hearts were subjected... -
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- Phospholipase D inhibitor enhances radiosensitivity of breast cancer cells
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Son JC, Kang DW, Yang KM, Choi KY, Son TG, Min DS
- KMID: 2154257
- Exp Mol Med.
- 2013 Aug;45(8):e38.
Radiation and drug resistance remain the major challenges and causes of mortality in the treatment of locally advanced, recurrent and metastatic breast cancer. Dysregulation of phospholipase D (PLD) has been... -
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- Neutrophil Elastase Causes MUC5AC Mucin Synthesis Via EGF Receptor, ERK and NF-kB Pathways in A549 Cells
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Song JS, Cho KS, Yoon HK, Moon HS, Park SH
- KMID: 1115250
- Korean J Intern Med.
- 2005 Dec;20(4):275-283.
- doi: 10.3904/kjim.2005.20.4.275
BACKGROUND: Neutrophil elastase (NE) was found to increase the respiratory mucin gene, MUC5AC, although the molecular mechanisms of this process remain unknown. We attempted to determine the signal transduction pathway... -
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