- Protein kinase C micron plays an essential role in hypertonicity-induced heat shock protein 70 expression
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Lim YS, Lee JS, Huang TQ, Seo JS
- KMID: 1072940
- Exp Mol Med.
- 2008 Dec;40(6):596-606.
- doi: 10.3858/emm.2008.40.6.596
Heat shock protein 70 (HSP70), which evidences important functions as a molecular chaperone and anti-apoptotic molecule, is substantially induced in cells exposed to a variety of stresses, including hypertonic stress,... -
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- Transcriptional induction of DLC-1 gene through Sp1 sites by histone deacetylase inhibitors in gastric cancer cells
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Kim TY, Kim IS, Jong HS, Lee JW, Kim TY, Jung M, Bang YJ
- KMID: 1072944
- Exp Mol Med.
- 2008 Dec;40(6):639-646.
- doi: 10.3858/emm.2008.40.6.639
We previously reported that trichostatin A (TSA), a histone deacetylase (HDAC) inhibitor, induced DLC-1 mRNA expression and accumulated acetylated histones H3 and H4 associated with the DLC-1 promoter in DLC-1... -
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- Increased in vivo immunological potency of HB-110, a novel therapeutic HBV DNA vaccine, by electroporation
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Kim CY, Kang ES, Kim SB, Kim HE, Choi JH, Lee DS, Im SJ, Yang SH, Sung YC, Kim BM, Kim BG
- KMID: 1072947
- Exp Mol Med.
- 2008 Dec;40(6):669-676.
- doi: 10.3858/emm.2008.40.6.669
Pulse-induced permeabilization of cellular membranes, generally referred to as electroporation (EP), has been used for years as a tool to increase macromolecule uptake in tissues, including nucleic acids, for gene... -
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- Inhibition of LPS-induced cyclooxygenase 2 and nitric oxide production by transduced PEP-1-PTEN fusion protein in Raw 264.7 macrophage cells
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Lee SH, Lee YP, Kim SY, Jeong MS, Lee MJ, Kang HW, Jeong HJ, Kim DW, Sohn EJ, Jang SH, Kim YH, Kwon HJ, Cho SW, Park J, Eum WS, Choi SY
- KMID: 1072943
- Exp Mol Med.
- 2008 Dec;40(6):629-638.
- doi: 10.3858/emm.2008.40.6.629
Phosphatase and tensin homologue deleted on chromosome 10 (PTEN) is a tumor suppressor. Although it is well known to have various physiological roles in cancer, its inhibitory effect on inflammation... -
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- Identification of potential lung cancer biomarkers using an in vitro carcinogenesis model
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Kim JE, Koo KH, Kim YH, Sohn J, Park YG
- KMID: 1072951
- Exp Mol Med.
- 2008 Dec;40(6):709-720.
- doi: 10.3858/emm.2008.40.6.709
Lung cancer is one of the deadliest and commonly diagnosed neoplasms. Early diagnosis of this disease is critical for improving clinical outcome and prognosis. Because the early stages of lung... -
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- Glycoproteomic analysis of plasma from patients with atopic dermatitis: CD5L and ApoE as potential biomarkers
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Kim WK, Hwang HR, Kim DH, Lee PY, In YJ, Ryu HY, Park SG, Bae KH, Lee SC
- KMID: 1072948
- Exp Mol Med.
- 2008 Dec;40(6):677-685.
- doi: 10.3858/emm.2008.40.6.677
Atopic dermatitis (AD) is an inflammatory skin disorder that is both uncomfortable and distressing to patients, and its prevalence has been steadily increasing. It is obvious that the identification of... -
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- Lysophosphatidic acid receptor 2 and Gi/Src pathway mediate cell motility through cyclooxygenase 2 expression in CAOV-3 ovarian cancer cells
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Jeong KJ, Park SY, Seo JH, Lee KB, Choi WS, Han JW, Kang JK, Park CG, Kim YK, Lee HY
- KMID: 1072941
- Exp Mol Med.
- 2008 Dec;40(6):607-616.
- doi: 10.3858/emm.2008.40.6.607
Lysophosphatidic acid (LPA) is a bioactive phospholipids and involves in various cellular events, including tumor cell migration. In the present study, we investigated LPA receptor and its transactivation to EGFR... -
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- CD36 signaling inhibits the translation of heat shock protein 70 induced by oxidized low density lipoprotein through activation of peroxisome proliferators-activated receptor gamma
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Lee KJ, Ha ES, Kim MK, Lee SH, Suh JS, Lee SH, Park KH, Park JH, Kim DJ, Kang D, Kim BC, Jeoung D, Kim YK, Kim HD, Hahn JH
- KMID: 1072946
- Exp Mol Med.
- 2008 Dec;40(6):658-668.
- doi: 10.3858/emm.2008.40.6.658
Oxidized LDL (OxLDL), a causal factor in atherosclerosis, induces the expression of heat shock proteins (Hsp) in a variety of cells. In this study, we investigated the role of CD36,... -
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- Ectopic expression of cyclooxygenase-2-induced dedifferentiation in articular chondrocytes
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Lee WK, Yu SM, Cheong SW, Sonn JK, Kim SJ
- KMID: 1072952
- Exp Mol Med.
- 2008 Dec;40(6):721-727.
- doi: 10.3858/emm.2008.40.6.721
Cyclooxygenase-2 (COX-2) is known to modulate bone metabolism, including bone formation and resorption. Because cartilage serves as a template for endochondral bone formation and because cartilage development is initiated by... -
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- Transcription of the protein kinase C-delta gene is activated by JNK through c-Jun and ATF2 in response to the anticancer agent doxorubicin
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Min BW, Kim CG, Ko J, Lim Y, Lee YH, Shin SY
- KMID: 1072950
- Exp Mol Med.
- 2008 Dec;40(6):699-708.
- doi: 10.3858/emm.2008.40.6.699
Expression of protein kinase C-delta (PKC delta) is up-regulated by apoptosis-inducing stimuli. However, very little is known about the signaling pathways that control PKC delta gene transcription. In the present... -
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- Curcuminoid-phospholipid complex induces apoptosis in mammary epithelial cells by STAT-3 signaling
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Cucuzza LS, Motta M, Miretti S, Accornero , Baratta M
- KMID: 1072945
- Exp Mol Med.
- 2008 Dec;40(6):647-657.
- doi: 10.3858/emm.2008.40.6.647
Curcumin (from the rhizome of Curcuma longa) is well documented for its medicinal properties in Indian and Chinese systems of medicine where it is widely used for the treatment of... -
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- Ginsenoside Rb1 attenuates intestinal ischemia-reperfusion- induced liver injury by inhibiting NF-kappa B activation
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Wang J, Qiao L, Li Y, Yang G
- KMID: 1072949
- Exp Mol Med.
- 2008 Dec;40(6):686-698.
- doi: 10.3858/emm.2008.40.6.686
Intestinal ischemia-reperfusion (I/R) is an important event in the pathogenesis of multiple organ dysfunction syndrome (MODS). The aim of this study is to determine the effects of ginsenoside Rb1 on... -
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- Polarization of protective immunity induced by replication-incompetent adenovirus expressing glycoproteins of pseudorabies virus
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Han YW, Aleyas AG, George JA, Kim SJ, Kim HK, Yoon HA, Yoo DJ, Kang SH, Kim K, Eo SK
- KMID: 1072939
- Exp Mol Med.
- 2008 Dec;40(6):583-595.
- doi: 10.3858/emm.2008.40.6.583
Replication-incompetent adenoviruses expressing three major glycoproteins (gB, gC, and gD) of pseudorabies virus (PrV) were constructed and used to examine the ability of these glycoproteins to induce protective immunity against... -
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- Liposomal honokiol, a potent anti-angiogenesis agent, in combination with radiotherapy produces a synergistic antitumor efficacy without increasing toxicity
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Hu J, Chen LJ, Liu L, Chen X, Chen PL, Yang G, Hou WL, Tang MH, Zhang F, Wang XH, Zhao X, Wei YQ
- KMID: 1072942
- Exp Mol Med.
- 2008 Dec;40(6):617-628.
- doi: 10.3858/emm.2008.40.6.617
Honokiol is an active compound purified from magnolia that has been shown to induce cell differentiation, apoptosis, and anti-angiogenesis effects, as well as an enhancement in tumor growth delay in... -
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