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Irritable Bowel Syndrome: Is It Really a Functional Disorder? A New Perspective on Alteration of Enteric Nervous System

Jahng J, Kim YS

  • KMID: 2203563
  • J Neurogastroenterol Motil.
  • 2016 Apr;22(2):163-165.
  • doi: 10.5056/jnm16043
No abstract available.
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The Role of Central and Enteric Nervous Systems in the Control of the Retrograde Giant Contraction

Lang IM

  • KMID: 2203586
  • J Neurogastroenterol Motil.
  • 2016 Apr;22(2):321-332.
  • doi: 10.5056/jnm15141
BACKGROUND/AIMS: The role of the enteric (ENS) and central (CNS) nervous systems in the control of the retrograde giant contraction (RGC) associated with vomiting is unknown. METHODS: The effects of myotomy...
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Gastrointestinal Dysfunctions in Parkinson's Disease

Kim JS, Sung HY

Gastrointestinal symptoms are a frequent but usually underreported constituent of the clinical spectrum of Parkinson's disease (PD), and they contribute significantly to the disease-related morbidity and mortality. Virtually all parts...
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Role of Gut Microbiota-Gut Hormone Axis in the Pathophysiology of Functional Gastrointestinal Disorders

Fukui H, Xu X, Miwa H

  • KMID: 2417381
  • J Neurogastroenterol Motil.
  • 2018 Jul;24(3):367-386.
  • doi: 10.5056/jnm18071
Gut microbiota exert a pivotal influence on various functions including gastrointestinal (GI) motility, metabolism, nutrition, immunity, and the neuroendocrine system in the host. These effects are mediated by not only...
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Stem Cell in Pediatric Gastrointestinal Tract Disease: Hirschsprung Disease

Bae SH

Stem cell is characterized with self-renewal and mult-potency. Many pediatric gastrointestinal diseases have defect in enterocytes, enteric nervous system, and Interstitial cell of Cajal. Various kinds of stem cell could...
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The Morphological Study of the Protein Gene Product (PGP) 9.5-like Immunoreactive Enteric Nervous System in Murine Ileum: Close Relation to Interstitial Cells of Cajal (ICC) in Confocal Laser Scanning Microscopy

Chang IY, You HJ

  • KMID: 2030751
  • Korean J Anat.
  • 2002 Apr;35(2):153-159.
This study was performed to investigate the morphology of the enteric nervous system and interstitial cells of Cajal (ICC) in the murine ileum. The PGP9.5-like immunoreactive (PGP9.5-LI) neurons and the...
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The Pharmacological Regulation of Interstitial Cells of Cajal in the Small Intestine

Jun JY

  • KMID: 2307406
  • Korean J Neurogastroenterol Motil.
  • 2009 Dec;15(2):93-99.
It is now known that certain class of interstitial cells of Cajal (ICC) serves as pacemaker cells in the phasic portions of the gastrointestinal (GI) tract. They generate and propagate...
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Transmission of Synucleinopathies in the Enteric Nervous System of A53T Alpha-Synuclein Transgenic Mice

Lee HJ, Suk JE, Lee KW, Park SH, Blumbergs , Gai WP, Lee SJ

Parkinson's disease (PD) and dementia with Lewy bodies (DLB) are characterized by abnormal deposition of alpha-synuclein aggregates in many regions of the central and peripheral nervous systems. Accumulating evidence suggests...
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Anti-Enteric Neuronal Antibodies and the Irritable Bowel Syndrome

Wood JD, Liu S, Drossman D, Ringel Y, Whitehead

  • KMID: 2325863
  • J Neurogastroenterol Motil.
  • 2012 Jan;18(1):78-85.
BACKGROUND/AIMS: Functional gastrointestinal disorders are those in which no abnormal metabolic or physical processes, which can account for the symptoms, can be identified. The irritable bowel syndrome (IBS) is a...
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Calcitonin Gene-related Peptide Immunoreactivity in the Muscle Layer of Small Intestine; Its Action on Interstitial Cell

Yoon SP, Jun JY, Lim Y, Kim IJ, Kim JY, Kim JM, Chang IY

  • KMID: 1609465
  • Korean J Phys Anthropol.
  • 2004 Sep;17(3):207-214.
In addition to the central and the peripheral nervous system, calcitonin gene-related peptide-like immunoreactivity (CGRP-LI) has been identified throughout the enteric nervous system. Several functions of the CGRP in gastrointestinal...
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Aging-Related Changes and Disorders of Gastrointestinal Tract in the Elderly

Kim YS

The goal of this short review is to summarize physiologic changes in gastrointestinal (GI) tract with aging and common GI disorders in the elderly. Normal aging is associated with various...
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Gastroparesis Updates on Pathogenesis and Management

Liu N, Abell T

Gastroparesis (Gp) is a chronic disease that presents with clinical symptoms of early satiety, bloating, nausea, vomiting, and abdominal pain. Along with these symptoms, an objective finding of delayed gastric...
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Recent Achievements in Stem Cell Therapy for Pediatric Gastrointestinal Tract Disease

Bae SH

The field of stem cell research has been rapidly expanding. Although the clinical usefulness of research remains to be ascertained through human trials, the use of stem cells as a...
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The 5-hydroxytryptamine 4 Receptor Agonist-induced Actions and Enteric Neurogenesis in the Gut

Takaki M, Goto K, Kawahara I

  • KMID: 2381146
  • J Neurogastroenterol Motil.
  • 2014 Jan;20(1):17-30.
We explored a novel effect of 5-hydroxytryptamine 4 receptor (5-HT4R) agonists in vivo to reconstruct the enteric neural circuitry that mediates a fundamental distal gut reflex. The neural circuit insult...
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A Case of Eosinophilic Gastroenteritis Associated with Small Bowel Dysmotility

Sim SJ, Lee KJ, Hahm KB, Kim JH, Cho SW

  • KMID: 2307531
  • Korean J Neurogastroenterol Motil.
  • 2004 Dec;10(2):133-137.
Marked eosinophilic infiltration involving any layer of the stomach and small bowel is characteristic of eosinophilic gastroenteritis. Presenting symptoms and clinical manifestations depend on the extent and wall layer of...
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Optical Tools to Investigate Cellular Activity in the Intestinal Wall

Boesmans W, Hao MM, Berghe PV

  • KMID: 2433473
  • J Neurogastroenterol Motil.
  • 2015 Jul;21(3):337-351.
  • doi: 10.5056/jnm15096
Live imaging has become an essential tool to investigate the coordinated activity and output of cellular networks. Within the last decade, 2 Nobel prizes have been awarded to recognize innovations...
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Development of myenteric plexus in human foetuses: a quantitative study

Singh S, Shariff A, Roy T, Das T, Rani N

Maturation of neurons of the myenteric plexus (MP) of human fetal sigmoid colon was studied at various weeks of gestation (WG). There is abundant literature on the development of MP...
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Changes in Enteric Neurons of Small Intestine in a Rat Model of Irritable Bowel Syndrome with Diarrhea

Li S, Fei G, Fang X, Yang X, Sun X, Qian J, Wood JD, Ke M

  • KMID: 2203585
  • J Neurogastroenterol Motil.
  • 2016 Apr;22(2):310-320.
  • doi: 10.5056/jnm15082
BACKGROUND/AIMS: Physical and/or emotional stresses are important factors in the exacerbation of symptoms in irritable bowel syndrome (IBS). Several lines of evidence support that a major impact of stress on...
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Expression of c-fos in the Myenteric Plexus of Rat Small Intestine Following Electrical Vagal Stimulation: Quantitative Analysis on the Vagally Activated Enteric Neurons

Cho BP, Park JC, Yang YC, Wang ZJ, Kang HS

  • KMID: 1559032
  • Korean J Anat.
  • 2001 Aug;34(4):405-414.
Activity of the enteric nervous system (ENS) is controlled by the autonomic nerves under the normal physiological condition, even though ENS has been regarded to be independent from the central...
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Expression of Bis in the mouse gastrointestinal system

Lee YD, Yoon JS, Yoon HH, Youn HJ, Kim J, Lee JH

The Bcl-2 interacting death suppressor (Bis) protein is known to be involved in a variety of pathophysiological conditions. We recently generated bis-deficient mice, which exhibited early lethality with typical nutritional...
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