- Reporting and Clinical Features of Adverse Drug Reactions
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- KMID: 2299498
- Korean J Asthma Allergy Clin Immunol.
- 2011 Sep;31(3):175-176.
No abstract available. -
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- Awareness of the adverse drug reaction in Korea
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- KMID: 2234475
- Korean J Asthma Allergy Clin Immunol.
- 2008 Mar;28(1):19-19.
No abstract available. -
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- Principles of antimicrobial therapy in elderly patients
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Kang CI
- KMID: 2259336
- Korean J Med.
- 2010 Oct;79(4):362-365.
Older persons generally have greater susceptibility to infections than younger adults, probably because of the increased frequency of comorbidities and physiologic changes. There are many factors, both patient-related and treatment-related,... -
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- Amiodarone-Induced Pulmonary Toxicity: Percutaneous Needle Aspiration Biopsy and Ultrastructural Findings
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Kang IS, Lee JH, Sung SH, Park SH
- KMID: 2171250
- Ewha Med J.
- 2013 Sep;36(2):144-148.
- doi: 10.12771/emj.2013.36.2.144
Amiodarone has been widely used for supraventricular and ventricular arrhythmias and many patients benefit from its effectiveness in treating potentially life-threatening arrhythmias. However, this drug can cause multi-organ toxicity, including... -
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- Scoring Methods for Prognosis of Patients with Acute Severe Organophosphate Intoxication
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Ha TW, Han YJ, Yoo SJ
- KMID: 2192625
- J Korean Soc Emerg Med.
- 2009 Dec;20(6):673-679.
PURPOSE: Although, there have been many reports about factors involved in the severity and prognosis of organophosphate toxicity, there are few reports on integrated application of scoring methods using those... -
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- Very Early Onset of Amiodarone-Induced Pulmonary Toxicity
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Lee W, Ryu DR, Han SS, Ryu SW, Cho BR, Kwon H, Kim BR
- KMID: 1826562
- Korean Circ J.
- 2013 Oct;43(10):699-701.
- doi: 10.4070/kcj.2013.43.10.699
Amiodarone is a widely used antiarrhythmic agent. Among its various adverse effects, amiodarone-induced pulmonary toxicity (APT) is the most life threatening complication, which has been described mostly in patients who... -
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- Management of vaccine safety in Korea
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Choe YJ, Bae GR
- KMID: 2391974
- Clin Exp Vaccine Res.
- 2013 Jan;2(1):40-45.
Although vaccination is regarded as one of the most effective public health measure to prevent and control infectious diseases, no vaccine is perfectly safe. Therefore, safety management is an essential... -
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- Risk management and principal features of REMS
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Lee JH
- KMID: 1787248
- J Korean Med Assoc.
- 2012 Sep;55(9):852-860.
- doi: 10.5124/jkma.2012.55.9.852
A safe drug is defined as one for which the benefit of the medication is greater than the expected risk, taking all factors into account. To enhance the safety of... -
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- Current status of pharmaceutical safety management in Korea
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Choi D, Choi M, Ko A
- KMID: 1787245
- J Korean Med Assoc.
- 2012 Sep;55(9):827-834.
- doi: 10.5124/jkma.2012.55.9.827
The reinforcement of regulation on of post-market safety management including adverse drug reactions (ADRs) has received significant emphasiszed significantly over the last several years in Korea. Not only has there... -
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- Unpredicted Severe Toxicity after 5-Fluorouracil Treatment due to Dihydropyrimidine Dehydrogenase Deficiency
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Baek JH, Kim JG, Kim SN, Kim DH, Sohn SK, Hong YJ, Lee KB
- KMID: 1782251
- Korean J Intern Med.
- 2006 Mar;21(1):43-45.
- doi: 10.3904/kjim.2006.21.1.43
Dihydropyrimidine dehydrogenase (DPD) is the initial and rate-limiting enzyme in the catabolism of 5-fluorouracil (5-FU). Thus, patients with a DPD deficiency are at risk of developing severe 5-FU-associated toxicity. A... -
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- Drug Interactions between Cardiovascular Agents and Psychotropic Drugs
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Park JE, Jung KH
- KMID: 1445924
- Korean J Psychosom Med.
- 2011 Dec;19(2):57-65.
There are numerous drug interactions related to many psychotropic and cardiovascular medications. Firstly, the principles in predicting drug interactions are discussed. Cytochrome P (CYP) 450 plays a significant role in... -
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- A Case of Bilateral Vestibular Hypofunction Following Oseltamivir Medication
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Kim HY, Ahn SK, Hur DG
- KMID: 1426906
- Res Vestib Sci.
- 2013 Mar;12(1):27-30.
The threat of pandemic influenza has focused attention and resources on virus surveillance, prevention, and containment. The World Health Organization has strongly recommended the use of the antiviral drug, Oseltamivir... -
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- Venlafaxine-Induced Acute Toxic Hepatitis
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Na KS, Hwang H, Kim SG, Lee SI, Jung HY
- KMID: 2250138
- Korean J Biol Psychiatry.
- 2011 Aug;18(3):159-162.
Venlafaxine is among the most widely prescribed antidepressants. It is extensively metabolized to O-desmethylvenlafaxine via cytochrome P450 (CYP) 2D6. We report a case of acute toxic hepatitis resulting from venlafaxine... -
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- Toxicity and Tolerability Study of Adjuvant TAC Regimen Chemotherapy in Korean Patients with Breast Cancer
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Woo HD, Kim HS, Lee JH, Kim HM, Han SW, Kim SY, Lim CW, Lee MH
- KMID: 1340913
- J Breast Cancer.
- 2011 Feb;14(Suppl 1):S44-S49.
- doi: 10.4048/jbc.2011.14.S.S44
PURPOSE: Recent randomized phase III trial by the Breast Cancer International Research Group (BCIRG 001) showed that docetaxel plus doxorubicin and cyclophosphamide (TAC) is superior to fluorouracil plus doxorubicin and... -
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- Hyperamylasemia following the trans-sphenoidal resection of pituitary tumor: can propofol-remifentanil TIVA cause postoperative hyperamylasemia?: A case report
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Lee HM, Kim SD, Kim OR, Jee DL
- KMID: 2116976
- Anesth Pain Med.
- 2011 Apr;6(2):160-163.
The trans-sphenoidal resection of a recurred pituitary tumor was performed in a 42 years old man under general anesthesia with propofol and remifentanil. Neither massive bleeding nor hypotension was observed... -
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- The role of the KIDS for enhancing drug safety and risk management in Korea
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Chung SY, Jung SY, Shin JY, Park BJ
- KMID: 1787249
- J Korean Med Assoc.
- 2012 Sep;55(9):861-868.
- doi: 10.5124/jkma.2012.55.9.861
Pharmacovigilance is defined as the science and activities relating to the detection, assessment, understanding and prevention of adverse effects or any other drug-related problem. The Korea Institute of Drug Safety... -
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- Drug Hypersensitivity Syndrome: A Literature Review of Associated Viral Reactivation
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- KMID: 2299508
- Korean J Asthma Allergy Clin Immunol.
- 2011 Jun;31(2):77-83.
Drug hypersensitivity syndrome is a severe adverse drug reaction characterized by skin eruption and systemic manifestations, such as fever, eosinophilia, lymph node enlargement, hepatitis and renal dysfunction. The pathogenic mechanism... -
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- Zolpidem, Is it a Safe Drug for Insomnia Management?
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Park KH, Lee JH
- KMID: 2142893
- Korean J Med.
- 2013 Jun;84(6):802-803.
Zolpidem is one of commonly prescribed hypnotics in worldwide. Zolpidem is more favored than benzodiazepines because of its efficacy and safety profiles. However there were many reports those concerns about... -
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- A Case of Nicolau Syndrome Treated with Non-steroidal Anti-inflammatory Drug Injection Therapy
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Chang HS, Moon HS, Lee JH, Park K, Son SJ
- KMID: 2247927
- Korean J Dermatol.
- 2009 Apr;47(4):459-462.
Nicolau syndrome, also known as livedoid dermatitis or embolia cutis medicamentosa, is a rare cutaneous adverse drug reaction characterized by the acute onset of cutaneous and soft-tissue necrosis following intramuscular... -
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- A Comparison of Active Surveillance Programs Including a Spontaneous Reporting Model for Phamacovigilance of Adverse Drug Events in a Hospital
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Yun IS, Koo MJ, Park EH, Kim SE, Lee JH, Park JW, Hong CS
- KMID: 2432937
- Korean J Intern Med.
- 2012 Dec;27(4):443-450.
BACKGROUND/AIMS: Spontaneous reporting systems have several weak points, such as low reporting rates and insufficient clinical information. Active surveillance programs, such as ward rounds and a clinical data repository (CDR),... -
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