- Animal Models of Inflammatory Bowel Disease
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Jang BI
- KMID: 2174062
- Intest Res.
- 2008 Jun;6(1):8-18.
Inflammatory bowel disease (IBD) is a chronic inflammatory disease of unknown etiology that includes two main disease entities-ulcerative colitis and Crohn's disease. Although the pathogenesis of IBD remains unclear, it... -
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- Etiopathology of Behcet's disease: herpes simplex virus infection and animal model
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Sohn S
- KMID: 2158063
- Yonsei Med J.
- 1997 Dec;38(6):359-364.
- doi: 10.3349/ymj.1997.38.6.359
The etiology of Behcet's disease has been proposed as being a viral, bacterial, genetic and immunological disorder. After Hulusi Behcet's viral etiological hypothesis, many investigators have tried to confirm this.... -
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- Recent progress in lysosomal alpha-mannosidase and its deficiency
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Sun H, Wolfe JH
- KMID: 755109
- Exp Mol Med.
- 2001 Mar;33(1):1-7.
Lysosomal alpha-mannosidase (EC 3.2.1.24) is a major exoglycosidase in the glycoprotein degradation pathway. A deficiency of this enzyme causes the lysosomal storage disease, alpha-mannosidosis, which has been described in humans,... -
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- Prion; the unconventional slow infectious agent
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Kim YS
- KMID: 645022
- J Korean Med Sci.
- 1997 Feb;12(1):1-8.
- doi: 10.3346/jkms.1997.12.1.1
No abstract available. -
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- Experimental Atherosclerosis in Pigs
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Lee KT
- KMID: 693058
- Yonsei Med J.
- 1987 Mar;28(1):1-5.
- doi: 10.3349/ymj.1987.28.1.1
No abstract available. -
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- New Insights in the Clinical Understanding of Behcet's Disease
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Cho SB, Cho S, Bang D
- KMID: 1779684
- Yonsei Med J.
- 2012 Jan;53(1):35-42.
- doi: 10.3349/ymj.2012.53.1.35
Behcet's disease is a chronic relapsing multisystemic inflammatory disorder characterized by four major symptoms (oral aphthous ulcers, genital ulcers, skin lesions, and ocular lesions) and occasionally by five minor symptoms... -
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- Evaluation of Three Different Methods to Establish Animal Models of Acanthamoeba Keratitis
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Ren M, Wu X
- KMID: 1779617
- Yonsei Med J.
- 2010 Jan;51(1):121-127.
- doi: 10.3349/ymj.2010.51.1.121
PURPOSE: To produce animal models of Acanthamoeba keratitis and to evaluate the advantages and adaptation range of each of the three methods employed. MATERIALS AND METHODS: Mice and Wistar rats... -
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- Experimental autoimmune myasthenia gravis and CD5+ B-lymphocyte expression
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Lee KW, Lee SH, Kim HJ, Kim JM, Choi YM, Motomura M
- KMID: 1062201
- J Korean Med Sci.
- 1999 Feb;14(1):75-79.
- doi: 10.3346/jkms.1999.14.1.75
Myasthenia gravis is one of the typical organ specific autoimmune disease and the CD5+ B-lymphocytes are known to be associated with the secretion of autoimmune antibodies. The authors performed the... -
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- Molecular genetic decoding of malformations of cortical development
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Lim JS, Lee JH
- KMID: 2055584
- J Genet Med.
- 2015 Jun;12(1):12-18.
- doi: 10.5734/JGM.2015.12.1.12
Malformations of cortical development (MCD) cover a broad spectrum of developmental disorders which cause the various clinical manifestations including epilepsy, developmental delay, and intellectual disability. MCD have been clinically classified... -
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- Physiologic and pathologic experimental models for studying cholangiocytes
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Lee SO
- KMID: 760778
- Korean J Hepatol.
- 2008 Jun;14(2):139-149.
- doi: 10.3350/kjhep.2008.14.2.139
Cholangiocytes (epithelial cells lining the intra- and extrahepatic bile ducts) and hepatocytes are two major components of liver epithelia. Although cholangiocytes are less numerous than hepatocytes, they are involved in... -
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- Unique Hippocampal Changes and Allodynia in a Model of Chronic Stress
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Kim SH, Moon IS, Park IS
- KMID: 2158046
- J Korean Med Sci.
- 2013 Jun;28(6):946-950.
- doi: 10.3346/jkms.2013.28.6.946
Sustained stress can have numerous pathologic effects. There have been several animal models for chronic stress. We tried to identify the changes of pain threshold and hippocampus in a model... -
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- Surgically induced degenerative changes in the femorotibial joints by total medial meniscectomy in minipigs closely resemble late-stage osteoarthritis
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Lee WJ, Park BJ, Lee HJ, Jang SJ, Lee SL, Lee JH, Rho GJ, Kim SJ
- KMID: 2448106
- Korean J Vet Res.
- 2019 Mar;59(1):17-24.
- doi: 10.14405/kjvr.2019.59.1.17
Animal models of osteoarthritis (OA) have played a key role in understanding the etiology of OA and in the development of new therapeutic strategies. Although pigs have an advantage as... -
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- BCG infection during pre-sensitization or even post-sensitization inhibits airway sensitivity in an animal model of allergic asthma
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Koh YI, Choi IS, Park SC, Kang KW
- KMID: 1128622
- J Korean Med Sci.
- 2000 Jun;15(3):265-272.
- doi: 10.3346/jkms.2000.15.3.265
The objective of this study is to investigate whether BCG infection before, during or after sensitization suppresses allergen-induced airway hyperresponsiveness and eosinophilic inflammation in allergic asthma rats, and to determine... -
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- Exosomes as Therapeutic Vehicles for Cancer
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Lim W, Kim HS
- KMID: 2449233
- Tissue Eng Regen Med.
- 2019 Jun;16(3):213-223.
- doi: 10.1007/s13770-019-00190-2
BACKGROUND: Exosomes are membrane-enclosed extracellular vesicles implicated in cell-cell communication. Exosomes contain proteins, mRNAs, non-coding RNAs (miRNAs and lncRNAs) and lipids that are derived from producing cells. These nano-sized vesicles... -
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- Histologic change of the posterior attachment in anterior disc displacement of the temporomandibular joint - a new model of internal derangement in rabbits
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Kim TW, Ko JS, Chang YI
- KMID: 2271351
- Korean J Orthod.
- 1993 Dec;23(4):503-527.
This paper describes a new method to create an animal model for TMJ internal derangement in the New Zealand white rabbits and the light and electron microscopical changes of posterior... -
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- Immune mechanisms of Theiler's virus-induced demyelination
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Kim BS, Palna JP
- KMID: 755038
- Exp Mol Med.
- 1999 Sep;31(3):115-121.
No abstract available. -
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- Sleep, circadian rhythms, and the pathogenesis of Alzheimer Disease
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Musiek ES, Xiong DD, Holtzman D
- KMID: 2155413
- Exp Mol Med.
- 2015 Mar;47(3):e148.
- doi: 10.1038/emm.2014.121
Disturbances in the sleep-wake cycle and circadian rhythms are common symptoms of Alzheimer Disease (AD), and they have generally been considered as late consequences of the neurodegenerative processes. Recent evidence... -
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- Stem cell therapy for Alzheimer's disease and related disorders: current status and future perspectives
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Tong LM, Fong H, Huang Y
- KMID: 2155416
- Exp Mol Med.
- 2015 Mar;47(3):e151.
- doi: 10.1038/emm.2014.124
Underlying cognitive declines in Alzheimer's disease (AD) are the result of neuron and neuronal process losses due to a wide range of factors. To date, all efforts to develop therapies... -
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- An Experimental Animal Model of Fulminant Hepatic Failure in Pigs
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Lee KU, Zheng LX, Cho YB, Kim KH, Ha J, Suh KS, Jung SE
- KMID: 1778501
- J Korean Med Sci.
- 2005 Jun;20(3):427-432.
- doi: 10.3346/jkms.2005.20.3.427
The objective of this study was to develop an experimental animal model of fulminant hepatic failure to test the efficacy of the bioartificial liver system. The portal vein and the... -
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- Genistein activates endothelial nitric oxide synthase in broiler pulmonary arterial endothelial cells by an Akt-dependent mechanism
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Yang Y, Nie W, Yuan J, Zhang B, Wang Z, Wu Z, Guo Y
- KMID: 994400
- Exp Mol Med.
- 2010 Nov;42(11):768-776.
- doi: 10.3858/emm.2010.42.11.078
Deregulation of endothelial nitric oxide synthase (eNOS) plays an important role in the development of multiple cardiovascular diseases. Our recent study demonstrated that genistein supplementation attenuates pulmonary arterial hypertension in... -
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