Yonsei Med J.  1997 Dec;38(6):359-364. 10.3349/ymj.1997.38.6.359.

Etiopathology of Behcet's disease: herpes simplex virus infection and animal model

• Sohn S

• KMID: 2158063
• DOI: http://doi.org/10.3349/ymj.1997.38.6.359

Abstract

The etiology of Behcet's disease has been proposed as being a viral, bacterial, genetic and immunological disorder. After Hulusi Behcet's viral etiological hypothesis, many investigators have tried to confirm this. Scrapings and fluids from patients were applied to subculture in chorioallantoic membranes of fertilized eggs as well as in mice and rabbits by direct intracerebral injection. Since the 1980s, in situ hybridization, blotting, and polymerase chain reaction has also been applied to identify the herpes simplex virus DNA and RNA in patients. Animal models were developed based on environmental pollutants, bacterial and human heat shock protein derived peptides and virus injection. Using these animal models separately and/or concurrently, allows for a more effective investigation into Behcet's disease.

Keyword

Behcet's disease; etiology; herpes simplex virus; animal model

MeSH Terms

Amino Acid Sequence
Animal
Behcet's Syndrome/etiology*
Disease Models, Animal*
Herpes Simplex/complications*
Human
Mice
Molecular Sequence Data
Rabbits