- Autoradiographic Investigation for 3H-Thymidine Labeling Indicies of gamma-Glutamyl Transpeptidase Positive Foci during the Rat Liver Carcinogenesis
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Kweon KW, Kim HJ, Lee SH, Cho YJ, Kim JC, Kim SW, Kim HS, Back IG, Jung CH, Jo YH, Gham CW, Lee DH
- KMID: 2143305
- Korean J Hepatol.
- 1998 Jun;4(2):162-178.
No abstract available. -
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- Induction of cell deathin early developmental phase of zebrafish treated with diethylnitrosamine
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Kang JS
- KMID: 2463591
- J Biomed Transl Res.
- 2019 Sep;20(3):53-57.
- doi: 10.12729/jbtr.2019.20.3.053
The purpose of this study was to investigate diethylnitrosamine (DEN)-induced liver damage in zebrafish. Zebrafish larvae were divided into five groups after seventy-two hours fertilization: group 1 (G1) as control,... -
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- The Enhancing Effect of Ethanol on the Development of Glutatione S-Transferase Placental Form-Positive Foci Induced by Diethylnitrosamine in F344 Rat
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Cho KJ, Myung NH, Jang JJ
- KMID: 1421473
- J Korean Med Sci.
- 1990 Mar;5(1):13-17.
- doi: 10.3346/jkms.1990.5.1.13
The effects of ethyl alcohol and pig serum administration on the development of preneoplastic hepatic enzyme-altered foci were examined in an in vivo mid-term assay system. Rats were initially given... -
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- Lung adenoma development and NK activity in mice treated with multiple carcinogens
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Lee YS, Seo JS, Chung HT, Cho KJ, Jang JJ
- KMID: 1421882
- J Korean Med Sci.
- 1992 Mar;7(1):1-5.
- doi: 10.3346/jkms.1992.7.1.1
A wide-spectrum initiation model was investigated in mice. Sequential treatments with diethylnitrosamine, urethane and N-methylnitrosourea, with or without a promoter, phenobarbital, resulted in tumor formation in the lungs in... -
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- Increase of proliferation and DNA damage in mouse hepatocytes treated with diethylnitrosamine
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Lee WK, Kang JS
- KMID: 2394588
- J Biomed Transl Res.
- 2017 Jun;18(2):56-59.
- doi: 10.12729/jbtr.2017.18.2.056
As diethylnitrosamine (DEN) effect on cell proliferation, DNA damage and stem cell marker(s) expression have been largely unknown in mouse normal hepatocytes (AML-12 cells) cultured over a short-term period, this... -
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- Expression of CD44 in mouse diethylnitrosamine (DEN)-induced hepatic tumors as well as in DEN-treated embryo stem cells and derived hepatic lineage cells
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Kang JS, Kim DJ
- KMID: 1703517
- J Biomed Res.
- 2013 Dec;14(4):230-234.
To clarify the role of stem cells in hepatocarcinogenesis, CD44 expression was investigated in mouse livers as well as embryonic cell lineages treated with diethylnitrosamine (DEN). Liver tumors induced by... -
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- Expression of Proteins Related Cell Cycle and Apoptosis during Diethylnitrosamine (DEN)-induced Hepatocarcinogenesis in Rats
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Sim WJ, Kim YS, Choi YS, Kim BG, Cha SJ, Lim HM, Park ES
- KMID: 1476240
- J Korean Surg Soc.
- 2008 Dec;75(6):359-367.
PURPOSE: To explore the role of cell cycle and apoptosis regulators during hepatocarcinogenesis, the expression of cell cycle-related proteins (cyclin D1 and p27kip1) and apoptosis-related proteins (p53, survivin, caspase 3). METHODS:... -
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- Anticarcinogenic Effect of Red Ginseng on the Development of Liver Cancer Induced by Diethylnitrosamine in Rats
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Wu XG, Zhu DH, Li X
- KMID: 1721176
- J Korean Med Sci.
- 2001 Dec;16(Suppl):S61-S65.
- doi: 10.3346/jkms.2001.16.S.S61
Anticarcinogenic effect of red ginseng (Panax ginseng C.A. Meyer cultivated in JiLin, China) on the development of liver cancer induced by diethylnitrosamine (DEN) in rats was studied, especially in preventive... -
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- Expression of Factor VIII Related Antigen and Changes of Serum IL-1alpha, IL-1beta and IL-6 during Diethylnitrosamine (DEN) Induced Carcinogenesis in Rat Liver
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Park YK, Lee HS, Park ES
- KMID: 2209975
- J Korean Surg Soc.
- 2004 Feb;66(2):73-80.
PURPOSE: In order to elucidate the tumor angiogenesis and to evaluate the usefulness of some cytokines as parameters of tumor progression and metastasis, we investigated the expression of Factor VIII... -
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- Protective Effect of Boiled and Freeze-dried Mature Silkworm Larval Powder Against Diethylnitrosamine-induced Hepatotoxicity in Mice
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Cho JM, Kim KY, Ji SD, Kim EH
- KMID: 2367575
- J Cancer Prev.
- 2016 Sep;21(3):173-181.
- doi: 10.15430/JCP.2016.21.3.173
BACKGROUND: Hepatocellular carcinoma (HCC) is a representative inflammation-associated cancer and known to be the most frequent tumors. HCC may also induce important pro- and anti-tumor immune reactions. However, the underlying... -
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- Development of altered hepatocyte foci by separate and combined treatments with radiation and diethylnitrosamine in neonatal rats
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Kim SH, Lee YS, Lee MS, Kim TH, Jang JJ
- KMID: 644814
- J Korean Med Sci.
- 1994 Aug;9(4):313-318.
- doi: 10.3346/jkms.1994.9.4.313
To establish an in vivo radiation carcinogenesis model using glutathione S-transferase placental form positive (GST-P+) hepatic foci, newborn rats were irradiated once by 0.5 Gy and 2 Gy of gamma... -
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- Effect of the Magnetized Water Supplementation on Lymphocyte DNA Damage in Mice Treated with Diethylnitrosamine
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Lee HJ, Jo HR, Jeon EJ, Kang MH
- KMID: 2268053
- Korean J Nutr.
- 2010 Dec;43(6):570-577.
- doi: 10.4163/kjn.2010.43.6.570
Water gets magnetically charged when it is contacted with a magnet. Although magnetic water products have been promoted since the 1930's, they have received very little recognition due to questionable... -
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- Study on mechanism of multistep hepatotumorigenesis in rat: development of hepatotumorigenesis
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Ha WS, Kim CK, Song SH, Kang CB
- KMID: 1103507
- J Vet Sci.
- 2001 Apr;2(1):53-58.
With the aim of establishing bio-indices for the development of multistep hepatotumorigenesis, rats were fed water containing 0.01% diethylnitrosamine (DEN) ad libitum for 13 weeks. This treatment with DEN only... -
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- Issues on carcinogen contaminated antihypertensive drugs and constructing drug safety management system
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Park BJ
- KMID: 2442732
- J Korean Med Assoc.
- 2019 Apr;62(4):182-185.
- doi: 10.5124/jkma.2019.62.4.182
European Medicines Agency withdrew valsartan from European market in July 2018 because it was contaminated with carcinogen, N-nitrosodimethylamine (NDMA) and N-nitrosodiethylamine (NDEA). Medicines and Healthcare Products Regulatory Agency also found... -
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- Periportal Distribution of Diethylnitrosamine-Induced Gamma-GTP Positive Foci in the Liver of Sprague-Dawley Rat
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Kim HJ, Lee SH, Back IG, Gham CW, Park DI, Jung CH, Jo YH, Nam SW, Lee DH
- KMID: 1531718
- Korean J Hepatol.
- 1997 Sep;3(3):252-263.
BACKGROUNR/AIMS: Heterogeneity of liver cell populations within the hepatic lobules can affect xenobiotic reaction. In this study, we attempt to clarify the stereological distribution of the y-GTP positive foci in hepatic lobule initiated... -
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- Differentially expressed proteins in the liver of Gulo-/- mice following treatments with Helicobacter pylori and diethylnitrosamine
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Nagappan A, Park HS, Park KI, Kim JA, Hong GE, Yumnam S, Kim EH, Lee WS, Lee WJ, Cho MJ, Lee WK, Won CK, Kim GS
- KMID: 1498928
- J Biomed Res.
- 2013 Jun;14(2):99-104.
Vitamin C (ascorbic acid) is an essential nutrient of most living tissues. We established a strain of Gulo-/- mice with known deficiency, in which vitamin C intake can be controlled... -
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- Stereological Analysis of gamma-Glutamyl Transpeptidase Positive Foci in Diethylnitrosamine-Induced Hepatocarcinogenesis of Sprague-Dawley Rats
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Yoo YK, Kim HJ, Lee SH, Gham CW, Kim HS, Kim JC, Nam SW, Kim SW, Kim BH, Yang SK, Park DI, Lee DH
- KMID: 2241334
- Korean J Hepatol.
- 1998 Mar;4(1):46-58.
BACKGROUND/AIMS: Hepatocarcinogenesis of microscopically altered foci could be shown to be progressed into a trabecular pattern of hepatocellular carcinoma. And it is reported that down-regulation of TGF beta II receptor and up-regulation... -
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- Correlation of changes in natural killer cell activity and glutathione S-transferase placental form positive hepatocytes in diethylnitrosamine-induced rat hepatocarcinogenesis
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Lee YS, Choe GY, Kim YI, Park SH, Park IA, Lee MJ, Jang JJ
- KMID: 648076
- J Korean Med Sci.
- 1999 Apr;14(2):171-174.
- doi: 10.3346/jkms.1999.14.2.171
To evaluate the induction of preneoplastic hepatic foci in relation to natural killer cell (NK) activity, we sequentially analyzed glutathione S-transferase placental form positive (GST-P+) hepatocytes and NK activity during ... -
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- Different modifying responses of capsaicin in a wide-spectrum initiation model of F344 rat
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Jang JJ, Cho KJ, Lee YS, Bae JH
- KMID: 1421512
- J Korean Med Sci.
- 1991 Mar;6(1):31-36.
- doi: 10.3346/jkms.1991.6.1.31
The modifying potential of capsaicin (CAP) on lesion development was examined in a rat multiorgan carcinogenesis model. Groups 1 and 2 were treated sequentially with diethylnitrosamine (DEN) (100 mg/kg, ip,... -
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- Expression of ErbB Receptor Proteins and TGF-alpha during Diethylnitrosamine-induced Hepatocarcinogenesis in the Rat Liver
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Lee TY, Kim KT, Han SY
- KMID: 760707
- Korean J Hepatol.
- 2007 Mar;13(1):70-80.
BACKGROUND/AIMS: ErbB receptor proteins are transmembrane tyrosine kinase receptors; when they are activated by interaction with ligands, they generate diverse cellular responses, especially during lesion development and progression to... -
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