J Korean Med Sci.  1992 Mar;7(1):1-5. 10.3346/jkms.1992.7.1.1.

Lung adenoma development and NK activity in mice treated with multiple carcinogens

• Lee YS
• Seo JS
• Chung HT
• Cho KJ
• Jang JJ

• KMID: 1421882
• DOI: http://doi.org/10.3346/jkms.1992.7.1.1

Abstract

A wide-spectrum initiation model was investigated in mice. Sequential treatments with diethylnitrosamine, urethane and N-methylnitrosourea, with or without a promoter, phenobarbital, resulted in tumor formation in the lungs in 85-90% of animals, but did not produce any tumorous lesions in other organs. The lung tumors were adenomas and the mean number of adenomas was 2.2-2.6 per mouse. Phenobarbital combination had no additive effect on lung tumor incidence and multiplicity. Splenic NK cell activity showed inconsistent increment in the carcinogen plus phenobarbital-treated group during the experiment (P less than 0.05).

Keyword

Wide-spectrum carcinogenesis; Multiple carcinogens; Lung adenoma; NK cell activity

MeSH Terms

*Adenoma/chemically induced/immunology
Animals
Diethylnitrosamine/pharmacology
Female
*Killer Cells, Natural/drug effects
*Lung Neoplasms/chemically induced/immunology
Methylnitrosourea/pharmacology
Mice
Phenobarbital/pharmacology
Random Allocation
Urethane/pharmacology
Phenobarbital
Urethane
Diethylnitrosamine
Methylnitrosourea