- Therapeutic Targeting of the DNA Damage Response Using an ATR Inhibitor in Biliary Tract Cancer
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Nam AR, Jin MH, Park JE, Bang JH, Oh DY, Bang YJ
- KMID: 2454308
- Cancer Res Treat.
- 2019 Jul;51(3):1167-1179.
- doi: 10.4143/crt.2018.526
PURPOSE: The DNA damage response (DDR) is a multi-complex network of signaling pathways involved in DNA damage repair, cell cycle checkpoints, and apoptosis. In the case of biliary tract cancer... -
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- Expression of DNA Damage Response Proteins and Associations with Clinicopathologic Characteristics in Chinese Familial Breast Cancer Patients with BRCA1/2 Mutations
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Zhu X, Tian T, Ruan M, Rao J, Yang W, Cai X, Sun M, Qin G, Zhao Z, Wu J, Shao Z, Shui R, Hu Z
- KMID: 2421370
- J Breast Cancer.
- 2018 Sep;21(3):297-305.
- doi: 10.4048/jbc.2018.21.e38
PURPOSE: The characteristic expression of DNA damage response proteins in familial breast cancers with BRCA1, BRCA2, or non-BRCA1/2 mutations has not been analyzed in Chinese patients. Our study aimed to... -
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- Lymphocyte DNA damage and plasma antioxidant status in Korean subclinical hypertensive patients by glutathione S-transferase polymorphism
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Han JH, Lee HJ, Choi HJ, Yun KE, Kang MH
- KMID: 2407769
- Nutr Res Pract.
- 2017 Jun;11(3):214-222.
- doi: 10.4162/nrp.2017.11.3.214
BACKGROUND/OBJECTIVES: Glutathione S-transferase (GST) forms a multigene family of phase II detoxification enzymes which are involved in the detoxification of xenobiotics by conjugating substances with glutathione. The aim of this... -
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- Increase of proliferation and DNA damage in mouse hepatocytes treated with diethylnitrosamine
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Lee WK, Kang JS
- KMID: 2394588
- J Biomed Transl Res.
- 2017 Jun;18(2):56-59.
- doi: 10.12729/jbtr.2017.18.2.056
As diethylnitrosamine (DEN) effect on cell proliferation, DNA damage and stem cell marker(s) expression have been largely unknown in mouse normal hepatocytes (AML-12 cells) cultured over a short-term period, this... -
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- Comparison of lymphocyte DNA damage levels and total antioxidant capacity in Korean and American diet
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Lee MY, Kim HA, Kang MH
- KMID: 2395291
- Nutr Res Pract.
- 2017 Feb;11(1):33-42.
- doi: 10.4162/nrp.2017.11.1.33
BACKGROUND/OBJECTIVE: This study aims to measure the in vitro antioxidant capacity of Korean diet (KD) with American diet (AD) as a control group and to examine the ex vivo DNA... -
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- Effects of lymphocyte DNA damage levels in Korean plant food groups and Korean diet regarding to glutathione S-transferase M1 and T1 polymorphisms
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Kim HA, Lee MY, Kang MH
- KMID: 2377977
- J Nutr Health.
- 2017 Feb;50(1):10-24.
- doi: 10.4163/jnh.2017.50.1.10
PURPOSE: GST (glutathione S-transferase) M1 and T1 gene polymorphisms are known to affect antioxidant levels. This study was carried out to evaluate genetic susceptibility by measuring the effect of DNA... -
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- Comparison of antioxidant activity and prevention of lymphocyte DNA damage by fruit and vegetable juices marketed in Korea
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Cho M, Lee HJ, Kang MH, Min H
- KMID: 2377976
- J Nutr Health.
- 2017 Feb;50(1):1-9.
- doi: 10.4163/jnh.2017.50.1.1
PURPOSE: Fruit and vegetable juices are known to be rich sources of antioxidants, which have beneficial effects on diseases caused by oxidative stress. The purpose of this study was to... -
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- DNA damage to human genetic disorders with neurodevelopmental defects
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Lee Y, Choi I, Kim J, Kim K
- KMID: 2327696
- J Genet Med.
- 2016 Jun;13(1):1-13.
- doi: 10.5734/JGM.2016.13.1.1
Although some mutations are beneficial and are the driving force behind evolution, it is important to maintain DNA integrity and stability because it contains genetic information. However, in the oxygen-rich... -
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- Caffeic Acid Phenethyl Ester Increases Radiosensitivity of Estrogen Receptor-Positive and -Negative Breast Cancer Cells by Prolonging Radiation-Induced DNA Damage
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Khoram NM, Bigdeli B, Nikoofar A, Goliaei B
- KMID: 2176317
- J Breast Cancer.
- 2016 Mar;19(1):18-25.
- doi: 10.4048/jbc.2016.19.1.18
PURPOSE: Breast cancer is an important cause of death among women. The development of radioresistance in breast cancer leads to recurrence after radiotherapy. Caffeic acid phenethyl ester (CAPE), a polyphenolic... -
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- Ethanol Extract of Cirsium japonicum var. ussuriense Kitamura Exhibits the Activation of Nuclear Factor Erythroid 2-Related Factor 2-dependent Antioxidant Response Element and Protects Human Keratinocyte HaCaT Cells Against Oxidative DNA Damage
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Yoo OK, Choi BY, Park JO, Lee JW, Park BK, Joo CG, Heo HJ, Keum YS
- KMID: 2161526
- J Cancer Prev.
- 2016 Mar;21(1):66-72.
- doi: 10.15430/JCP.2016.21.1.66
Keratinocytes are constantly exposed to extracellular insults, such as ultraviolet B, toxic chemicals and mechanical stress, all of which can facilitate the aging of keratinocytes via the generation of intracellular... -
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- Four months of magnetized water supplementation improves glycemic control, antioxidant status, and cellualr DNA damage in db/db mice
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Lee HJ, Kang MH
- KMID: 2366711
- J Nutr Health.
- 2016 Dec;49(6):401-410.
- doi: 10.4163/jnh.2016.49.6.401
PURPOSE: Water is magnetically charged upon contact with a magnet. Although magnetic water products have been promoted since the 1930's, they have not received wide acceptance since their effectiveness is... -
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- The Levels of Cortisol and Oxidative Stress and DNA Damage in Child and Adolescent Victims of Sexual Abuse with or without Post-Traumatic Stress Disorder
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Şimşek S, Yüksel T, Kaplan I, Uysal C, Aktaş H
- KMID: 2360378
- Psychiatry Investig.
- 2016 Nov;13(6):616-621.
- doi: 10.4306/pi.2016.13.6.616
OBJECTIVE: The aim of this study was to investigate whether cortisol and oxidative stress levels and DNA damage differ between individuals who developed PTSD or not following a sexual trauma. METHODS:... -
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- Protective effect of Korean diet food groups on lymphocyte DNA damage and contribution of each food group to total dietary antioxidant capacity (TDAC)
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Lee MY, Han JH, Kang MH
- KMID: 2357130
- J Nutr Health.
- 2016 Oct;49(5):277-287.
- doi: 10.4163/jnh.2016.49.5.277
PURPOSE: This study was performed to compare total phenolic contents, in vitro antioxidant capacity, and reduction effect of Korean food groups on ex vivo DNA damage in human cells and... -
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- Interactome Analysis Reveals that Heterochromatin Protein 1gamma (HP1gamma) Is Associated with the DNA Damage Response Pathway
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Kim H, Choi JD, Kim BG, Kang HC, Lee JS
- KMID: 2152291
- Cancer Res Treat.
- 2016 Jan;48(1):322-333.
- doi: 10.4143/crt.2014.294
PURPOSE: Heterochromatin protein 1gamma (HP1gamma) interacts with chromosomes by binding to lysine 9-methylated histone H3 or DNA/RNA. HP1gamma is involved in various biological processes. The purpose of this study is... -
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- Oxidative DNA Damage from Nanoparticle Exposure and Its Application to Workers' Health: A Literature Review
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Rim KT, Song SW, Kim HY
- KMID: 2317101
- Saf Health Work.
- 2013 Dec;4(4):177-186.
The use of nanoparticles (NPs) in industry is increasing, bringing with it a number of adverse health effects on workers. Like other chemical carcinogens, NPs can cause cancer via oxidative... -
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- Activation of ATM-dependent DNA Damage Signal Pathway by a Histone Deacetylase Inhibitor, Trichostatin A
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Lee JS
- KMID: 1522935
- Cancer Res Treat.
- 2007 Sep;39(3):125-130.
PURPOSE: Ataxia-telangiectasia mutated (ATM) kinase regulates diverse cellular DNA damage responses, including genome surveillance, cell growth, and gene expression. While the role of histone acetylation/deacetylation in gene expression is well... -
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- Functional Link between DNA Damage Responses and Transcriptional Regulation by ATM in Response to a Histone Deacetylase Inhibitor TSA
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Lee JS
- KMID: 1522934
- Cancer Res Treat.
- 2007 Sep;39(3):116-124.
PURPOSE: Mutations in the ATM (ataxia-telangiectasia mutated) gene, which encodes a 370 kd protein with a kinase catalytic domain, predisposes people to cancers, and these mutations are also linked to... -
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- The Effect of Alpha-tocopherol Supplementation on the Improvement of Antioxidant Status and Lymphocyte DNA Damage in Postmenopausal Women
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Kim CS, Kang HJ, Lee SH, Park YK, Kang MH
- KMID: 2260670
- Korean J Nutr.
- 2007 Dec;40(8):708-718.
The purpose of this project was to evaluate whether vitamin E supplementation could improve the antioxidant status and lymphocyte DNA damage in Korean postmenopausal women. This was double blinded, placebo-controlled... -
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- Effects of Different Mandarin Formulations on Antioxidative Capacity and Oxidative DNA Damage in Fifteen-Month Aged Rats
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Kim JH, Kwon S, Kim JK, Kim MK
- KMID: 2270032
- Korean J Nutr.
- 2006 Oct;39(7):610-616.
This study was performed to investigate the effect of whole mandarin, peel or pulp intake of Citrus unshiu Marc. on antioxidative capacity and oxidative DNA damage in fifteen-month aged rats.... -
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- The Effect of Green Vegetable Drink Supplementation on Cellular DNA Damage and Antioxidant Status of Korean Smokers
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Kim HY, Park YK, Kim TS, Kang MH
- KMID: 2269926
- Korean J Nutr.
- 2006 Jan;39(1):18-27.
Smoking is well known to be associated with increased indices of free radical-mediated damage of DNA, indicating that smoking may exacerbate the initiation and propagation of oxidative stresses, which are... -
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