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Next generation sequencing and urologic cancer

Kim SK, Kim WJ

No abstract available.
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Identification of integrated hepatitis B virus DNA sequences in human hepatocellular carcinomas in Korea

Lee HS, Kim ST, Kim CY

The rate of HBV DNA integration into the genome of hepatocellular carcinoma (HCC) cells varies greatly among HCC tissues from different geographical districts. Because of the potential etiological significance of...
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Liquid biopsy? A recent breakthrough in noninvasive bladder cancer surveillance

Kang M, Ku JH

No abstract available.
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Circulating Tumor Cell and Cell-free Circulating Tumor DNA in Lung Cancer

Nurwidya F, Zaini J, Putra AC, Andarini S, Hudoyo A, Syahruddin E, Yunus F

Circulating tumor cells (CTCs) are tumor cells that are separated from the primary site or metastatic lesion and disseminate in blood circulation. CTCs are considered to be part of the...
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Flow cytometric DNA analysis of gastric cancer--correlation with histology and clinical outcome

Suh KS, Min SK

Nuclear DNA content was analysed by means of flow cytometric measurements in 103 patients with gastric carcinomas, using paraffin-embedded archival tissue. DNA aneuploidy was found in 40 cases (38.8%). The...
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Value of urinary topoisomerase-IIA cell-free DNA for diagnosis of bladder cancer

Kim YH, Yan C, Lee IS, Piao XM, Byun YJ, Jeong P, Kim WT, Yun SJ, Kim WJ

PURPOSE: Topoisomerase-II alpha (TopoIIA ), a DNA gyrase isoform that plays an important role in the cell cycle, is present in normal tissues and various human cancers, and can show...
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Primary carcinoid tumor of the testis: immunohistochemical, ultrastructural and DNA flow cytometric study of two cases

Kim HJ, Cho MY, Park YN, Kie JH

Primary testicular carcinoid tumor, occupying 0.23% of testicular neoplasm, is a rare and indolent neoplasm with the potential for distant metastasis. We present two cases of primary pure carcinoid tumor...
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Comparison of bromodeoxyuridine and proliferating cell nuclear antigen labeling in gastric carcinoma

Kang SM, Kim WH, Kim CW, Kim YI

The proliferative activity of human gastric carcinoma was measured by means of in vitro incorporation of the thymidine analogue, 5-bromo-2'-deoxyuridine (BrdU), into the newly-synthesized DNA of fresh tumors and immunohistochemical...
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DNA flow cytometry in pheochromocytoma and paraganglioma

Jung WH, Yang WI, Park C, Choi IJ

Flow cytometric DNA analysis was performed on 19 adrenal pheochromocytomas and 6 extra-adrenal paragangliomas in parallel with clinical and histopathological review to determine the usefulness of this technique to predict...
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Quantification of Plasma DNA as a Tumor Marker in Patients with Pancreatic Cancer

Lee KH, Yoon WJ, Lee JK, Ryu JK, Kim YT, Yoon YB

  • KMID: 935215
  • Korean J Gastroenterol.
  • 2005 Sep;46(3):226-232.
BACKGROUND/AIMS: The plasma DNA concentration of patients with cancer is known to be higher than normal controls. Increased DNA concentration and tumor-specific genes in plasma can be used as tumor...
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Regulation of bcl-2 family in hydrogen peroxide-induced apoptosis in human leukemia HL-60 cells

Lee JE, Sohn JW, Lee JH, Lee KC, Son CS, Tockgo YC

  • KMID: 927133
  • Exp Mol Med.
  • 2000 Mar;32(1):42-46.
Numerous types of cells have been shown to undergo apoptosis when exposed to oxidant agent such as hydrogen peroxide. In order to understand the functional relationship between the anti- and...
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Flow cytometric analysis of DNA ploidy in childhood rhabdomyosarcoma

Jung WH, Jung SH, Yoo CJ, Kim YJ, Park C, Kim BS

Flow cytometric DNA analysis was performed on 17 rhabdomyosarcomas in conjunction with a histopathological review to determine the usefulness of this technique to predict the biologic behavior of the tumor...
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Detection of Plasma BRAF(V600E) Mutation Is Associated with Lung Metastasis in Papillary Thyroid Carcinomas

Kim BH, Kim IJ, Lee BJ, Lee JC, Kim IS, Kim SJ, Kim WJ, Jeon YK, Kim SS, Kim YK

PURPOSE: The BRAF(V600E) mutation represents a novel indicator of the progression and aggressiveness of papillary thyroid carcinoma (PTC). The purpose of this study was to determine the clinical significance of...
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Correlation of histopathologic classification with proliferative activity and DNA ploidy in 120 intracranial meningiomas, with special reference to atypical meningioma

Myong NH, Chi JG

Histologic classification of 120 meningiomas was correlated with their proliferative fraction and DNA ploidy using immunohistochemistry and flow cytometry to differentiate histologically atypical meningiomas from benign ones....
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Clear cell sarcoma of the kidney : immunohistochemical study and flow cytometric DNA analysis of 7 cases

Choi YJ, Jung WH, Jung SH, Park C

Immunohistochemical study and flow cytometric DNA analysis were done on seven cases of clear cell sarcoma of the kidney (CCSK) to speculate its histogenesis and to access the diagnostic usefulness...
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Clinicopathological Characteristics of Colorectal Cancer with Family History: an Evaluation of Family History as a Predictive Factor for Microsatellite Instability

Park IJ, Kim HC, Yoon YS, Yu CS, Jang SJ, Kim JC

To determine whether family history of cancer may be a risk factor for the mutator phenotype in colorectal cancer, we recruited 143 consecutive colorectal cancer patients with a family history...
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DNA ploidy and proliferative activity in bcl-2 expressed non-small cell lung cancer

Kim YC, Park KO, Kim HJ, Choi IS, Park CS, Juhng SW

  • KMID: 1051550
  • Korean J Intern Med.
  • 1996 Jun;11(2):101-107.
OBJECTIVES: The expressions of bcl-2 have been reported recently in non-small cell lung carcinoma (NSCLC*). As oncogensis is believed to involve a number of genetic alterations, there can be differences...
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DNA analysis by flow cytometry in early gastric cancer

Kim JM, Lee DK, Kim YK, Baik SK, Lee CI, Kwon SO, Jung SH

  • KMID: 1051580
  • Korean J Intern Med.
  • 1997 Jun;12(2):137-143.
OBJECTIVES: Flow cytometric analysis of a paraffin-embedded block of tissue provides rapid and accurate means of analyzing the DNA content of a tumor. The aim of this study was to...
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A Modified Extraction Method of Circulating Free DNA for Epidermal Growth Factor Receptor Mutation Analysis

Yuan H, Zhu ZZ, Lu Y, Liu F, Zhang W, Huang G, Zhu G, Jiang B

PURPOSE: Circulating free DNA (cfDNA) in plasma is promising to be a surrogate for tumor tissue DNA. However, not all epidermal growth factor receptor (EGFR) mutations in tumor tissue DNA...
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Immunohistochemical characteristics of colorectal carcinoma with DNA replication errors

Kim H, Jung JK, Park JH, Park C

It has recently been shown that nearly all cancers from hereditary nonpolyposis colorectal cancer syndrome (HNPCC), as well as a subset of sporadic colorectal cancers, have DNA replication errors (RER)...
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