- Phosphodiesterase 4D Gene and Risk of Noncardiogenic Ischemic Stroke in a Korean Population
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Kim MK, Kim JT, Choi SM, Lee SH, Park MS, Cho KH
- KMID: 1779135
- J Korean Med Sci.
- 2009 Apr;24(2):307-310.
- doi: 10.3346/jkms.2009.24.2.307
Recently published studies from different populations provide apparently conflicting evidence on the association between the phosphodiesterase 4D (PDE4D) gene and ischemic stroke. The relationship between a representative PDE4D genotype and... -
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- The Effect of Phosphodiesterase-4-Specific Inhibitor in the Rat Model of Spinal Nerve Ligation
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Kim SH, Park BN, Kim SW
- KMID: 1814115
- J Korean Neurosurg Soc.
- 2011 Aug;50(2):109-113.
- doi: 10.3340/jkns.2011.50.2.109
OBJECTIVE: Peripheral neuropathy is characterized by hyperalgesia, spontaneous burning pain, and allodynia. The purpose of this study was to investigate the effect of rolipram, a phosphodiesterase-4-specific inhibitor, in a segmental... -
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- Specific Expression of Aplysia Phosphodiesterase 4 in Bag Cells Revealed by in situ Hybridization Analysis
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Jang DJ, Kim HF, Sim JH, Lim CS, Kaang BK
- KMID: 2165561
- Exp Neurobiol.
- 2015 Sep;24(3):246-251.
- doi: 10.5607/en.2015.24.3.246
Phosphodiesterases (PDEs) play a key role in the regulation of cyclic adenosine monophosphate (cAMP), which in turn mediates various cellular functions including learning and memory. We previously cloned and characterized... -
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- Pharmacotherapy for chronic obstructive pulmonary disease
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Kim IA, Park YB, Yoo KH
- KMID: 2420365
- J Korean Med Assoc.
- 2018 Sep;61(9):545-551.
- doi: 10.5124/jkma.2018.61.9.545
The goals of management of stable chronic obstructive pulmonary disease (COPD) are to reduce both current symptoms and future risks with minimal side effects from treatment. Identification and reduction of... -
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- Incidence of Adverse Effects and Discontinuation Rate between Patients Receiving 250 Micrograms and 500 Micrograms of Roflumilast: A Comparative Study
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Joo H, Han D, Lee JH, Rhee CK
- KMID: 2420563
- Tuberc Respir Dis.
- 2018 Oct;81(4):299-304.
- doi: 10.4046/trd.2018.0015
BACKGROUND: Roflumilast is the only approved oral phosphodiesterase-4 inhibitor for the treatment of severe chronic obstructive pulmonary disease (COPD) in patients with chronic bronchitis and a history of frequent exacerbations.... -
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- Effect of a Dose-Escalation Regimen for Improving Adherence to Roflumilast in Patients with Chronic Obstructive Pulmonary Disease
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Hwang H, Shin JY, Park KR, Shin JO, Song KH, Park J, Park JW
- KMID: 2320700
- Tuberc Respir Dis.
- 2015 Oct;78(4):321-325.
- doi: 10.4046/trd.2015.78.4.321
BACKGROUND: The adverse effects of the phosphodiesterase-4 inhibitor roflumilast, appear to be more frequent in clinical practice than what was observed in chronic obstructive pulmonary disease (COPD) clinical trials. Thus,... -
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- Electrophysiological and Behavioral Changes by Phosphodiesterase 4 Inhibitor in a Rat Model of Alcoholic Neuropathy
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Han KH, Kim SH, Jeong IC, Lee YH, Chang SJ, Park BN, Kim SW
- KMID: 2190520
- J Korean Neurosurg Soc.
- 2012 Jul;52(1):32-36.
- doi: 10.3340/jkns.2012.52.1.32
OBJECTIVE: Alcoholic neuropathy is characterized by allodynia (a discomfort evoked by normally innocuous stimuli), hyperalgesia (an exaggerated pain in response to painful stimuli) and spontaneous burning pain. The aim of... -
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- The Modulation of IL-12 by Phosphodiesterase IV Inhibitor and Subsequent Changes of Th-1, Th-2 Cytokines in Human Endometrial Tissue
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Park WI, Kim EK, Ko DS, Hong SY, Na JY, Shin JH, Kim DW
- KMID: 2272121
- Korean J Obstet Gynecol.
- 2003 Aug;46(8):1500-1509.
OBJECTIVE: To assess the capability of phosphodiesterase type IV inhibitor (rolipram) to suppress IL-12 in human decidua and the subsequent changes of Th-2 cytokine (IL-10) and Th-1 cytokine (TNF-alpha). METHODS: Decidual... -
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- The Phosphodiesterase 4 Inhibitor Roflumilast Protects against Cigarette Smoke Extract-Induced Mitophagy-Dependent Cell Death in Epithelial Cells
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Kyung SY, Kim YJ, Son ES, Jeong SH, Park JW
- KMID: 2420602
- Tuberc Respir Dis.
- 2018 Apr;81(2):138-147.
- doi: 10.4046/trd.2017.0115
BACKGROUND: Recent studies show that mitophagy, the autophagy-dependent turnover of mitochondria, mediates pulmonary epithelial cell death in response to cigarette smoke extract (CSE) exposure and contributes to the development of... -
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- Comparisons of the Characteristics for Non-hospitalized, Hospitalized, and Rehospitalized Patients due to Acute Exacerbation of Chronic Obstructive Pulmonary Disease
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Choi JY, Yun SY
- KMID: 2455724
- Korean J Adult Nurs.
- 2019 Aug;31(4):427-438.
- doi: 10.7475/kjan.2019.31.4.427
PURPOSE: This study compares the characteristics of patients with Chronic Obstructive Pulmonary Disease (COPD) according to hospitalization frequency due to Acute Exacerbation (AE) using a retrospective medical records review. METHODS: From... -
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- Relaxant and anti-inflammatory effect of two thalidomide analogs as PDE-4 inhibitors in pregnant rat uterus
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Muñoz-Pérez VM, Fernández-MartÃnez E, Ponce-Monter H, Ortiz MI
- KMID: 2384457
- Korean J Physiol Pharmacol.
- 2017 Jul;21(4):429-437.
- doi: 10.4196/kjpp.2017.21.4.429
The aim of this study was to evaluate the relaxant and anti-inflammatory effects of two thalidomide analogs as phosphodiesterase-4 (PDE-4) inhibitors in pregnant rat uterus. Uteri from Wistar female rats... -
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