J Korean Neurosurg Soc.  2011 Aug;50(2):109-113. 10.3340/jkns.2011.50.2.109.

The Effect of Phosphodiesterase-4-Specific Inhibitor in the Rat Model of Spinal Nerve Ligation

• Kim SH
• Park BN
• Kim SW

• KMID: 1814115
• DOI: http://doi.org/10.3340/jkns.2011.50.2.109

Abstract

OBJECTIVE
Peripheral neuropathy is characterized by hyperalgesia, spontaneous burning pain, and allodynia. The purpose of this study was to investigate the effect of rolipram, a phosphodiesterase-4-specific inhibitor, in a segmental spinal nerve ligation model in rats.
METHODS
Both the L5 and L6 spinal nerves of the left side of the rats were ligated. Phosphodiesterase-4 inhibitor (rolipram) and saline (vehicle) were administered intraperitoneally. We measured mechanical allodynia using von Frey filaments and a nerve conduction study.
RESULTS
The mechanical allodynia, which began to manifest on the first day, peaked within 2 days. Multiple intraperitoneal injections of rolipram ameliorated the mechanical allodynia. Furthermore, an intraperitoneal administration of rolipram improved the development of pain behavior and nerve conduction velocity.
CONCLUSION
This study suggests that the phosphodiesterase-4 inhibitor, rolipram, alleviates mechanical allodynia induced by segmental spinal nerve ligation in rats. This finding may have clinical implications.

Keyword

Peripheral nerve injury; Allodynia; Rolipram

MeSH Terms

Animals
Burns
Cyclic Nucleotide Phosphodiesterases, Type 4
Hyperalgesia
Injections, Intraperitoneal
Ligation
Neural Conduction
Peripheral Nerve Injuries
Peripheral Nervous System Diseases
Rats
Rolipram
Spinal Nerves
Cyclic Nucleotide Phosphodiesterases, Type 4
Rolipram