- Bisphenol A and 4-tert-Octylphenol Inhibit Cx46 Hemichannel Currents
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Oh S
- KMID: 2071822
- Korean J Physiol Pharmacol.
- 2015 Jan;19(1):73-79.
- doi: 10.4196/kjpp.2015.19.1.73
Connexins (Cx) are membrane proteins and monomers for forming gap junction (GJ) channels. Cx46 and Cx50 are also known to function as conductive hemichannels. As part of an ongoing effort... -
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- X-linked Charcot-Marie-Tooth disease case with a novel missense mutation in GJB1 gene
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Lee JM, Shin JH
- KMID: 2435951
- J Genet Med.
- 2018 Dec;15(2):107-109.
- doi: 10.5734/JGM.2018.15.2.107
X-linked Charcot-Marie-Tooth disease type 1 (CMTX1) is caused by the mutation in GJB1 gene, characterized by the transient central nervous system involvement and long standing peripheral polyneuropathy which does not... -
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- Effects of Connexin Expression on Unstable Bladder after Relief of Bladder Outlet Obstruction in Rat
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Kim JC, Kim DB, Seo SI, Park YH, Hwang TK
- KMID: 2293475
- Korean J Urol.
- 2003 Jun;44(6):585-591.
PURPOSE: Connexins (Cx) constitute a family of transmembrane proteins that form gap junction channels, and allow metabolic and electrical coupling of cellular networks. This study was undertaken to evaluate the... -
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- Effects of Connexin Expression on Detrusor Overactivity in Male Patients with Bladder Outlet Obstruction Caused by Benign Prostatic Hyperplasia
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Cha SH, Kim JC, Hwang TK
- KMID: 2293526
- Korean J Urol.
- 2004 Sep;45(9):897-902.
PURPOSE: Detrusor overactivity is frequently associated with bladder outlet obstruction, which may be related with increased electrical coupling. The effects of connexin 43(Cx43) and connexin 26(Cx26) mRNA expressions on the... -
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- The Significance of Connexin 26 Expression in Squamous Cell Lesions of the Larynx
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Kim SY, Cho SI, Do NY, Lee JH, Kim GH, Lim SC
- KMID: 2276756
- Korean J Otolaryngol-Head Neck Surg.
- 2007 May;50(5):442-447.
BACKGROUND AND OBJECTIVES: Gap junctional intercellular communication (GJIC) is a mechanism for direct cell to cell signalling and is mediated by gap junctions, which consist of transmembrane proteins called connexins... -
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- Effect of ACE Inhibitor on Connexin Expression after Bladder Outlet Obstruction in Rats
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Kim HS, Kim JC, Hwang TK
- KMID: 2293834
- Korean J Urol.
- 2005 Nov;46(11):1205-1212.
PURPOSE: Clinically, bladder outlet obstruction (BOO) causes not only obstructive symptoms but also overactive bladder symptoms which partially result from the increase of electrical coupling in the bladder. This study... -
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- Voltage Regulation of Connexin Channel Conductance
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Oh S, Bargiello
- KMID: 2352783
- Yonsei Med J.
- 2015 Jan;56(1):1-15.
- doi: 10.3349/ymj.2015.56.1.1
Voltage is an important parameter that regulates the conductance of both intercellular and plasma membrane channels (undocked hemichannels) formed by the 21 members of the mammalian connexin gene family. Connexin... -
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- Regulation of Gap Junctional Intercellular Communication in Human Keratinocyte Cells
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Kahng HS, Kim BC, Kang SO, Hong JJ, Jun HJ, Choung YH
- KMID: 1455600
- Korean J Otorhinolaryngol-Head Neck Surg.
- 2010 Nov;53(11):675-685.
- doi: 10.3342/kjorl-hns.2010.53.11.675
BACKGROUND AND OBJECTIVES: Unlike the normal skin, cholesteatomas characterized by hyperproliferative keratinocytes exhibits up-regulation of connexins (Cxs) and gap junctional intercellular communication (GJIC). Currently, there are no appropriate clinical methods... -
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- Altered Expressions of Calcium-Activated Potassium Channel and Connexin in Bladder Mucosae of Stress Urinary Incontinence Patients with Overactive Bladder Symptoms
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Kim DY, Kim JW, Yang EK
- KMID: 2294312
- Korean J Urol.
- 2006 Jul;47(7):722-728.
- doi: 10.4111/kju.2006.47.7.722
PURPOSE: The aim of this study was to examine how the mRNA and protein levels of calcium activated Kchannel (K(Ca)) and connexin (Cx) change in association with overactive bladder in... -
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- Alterations in Calcium-Activated Potassium Channel Expressions in Human Prostate Cancer
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Kim DY, Yang EK, Kim JW
- KMID: 2294143
- Korean J Urol.
- 2006 May;47(5):548-552.
- doi: 10.4111/kju.2006.47.5.548
PURPOSE: Recent studies have shown that potassium (K+) and sodium channels are involved in prostate cell growth. However, a great many of the studies have been done in prostate cancer... -
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- Sex Differences in Hippocampal Neuronal Sensitization by Nicotine in M. gerbils
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Hur YN, Lee J, Sohn SC, Won CG, Lee HH, Kim DH, Choi SH, Shin KH, Chun BG
- KMID: 1500234
- Korean J Physiol Pharmacol.
- 2013 Oct;17(5):405-409.
- doi: 10.4196/kjpp.2013.17.5.405
We studied the sex different nicotine effect on evoked population spike amplitudes (ePSA) and connexin (Cx) expression in the hippocampus CA1 area of gerbils. Acute doses of nicotine bitartrate (0.5... -
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- Ocular Manifestations and Histologic Characteristics of Keratitis-Ichthyosis-Deafness (KID) Syndrome
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Jeong JH, Chun YS, Lee SH, Jeong HS, Kim JC
- KMID: 2337672
- J Korean Ophthalmol Soc.
- 2008 Sep;49(9):1532-1538.
PURPOSE: Keratitis-ichthyosis-deafness (KID) syndrome is a congenital ectodermal disorder presenting the triad of vascularizing keratitis, erythrokeratoderma, and sensorineural deafness. Ocular manifestations such as hyperkeratinization of the eyelids, loss of eyelashes,... -
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- Hereditary Palmoplantar Keratoderma and Deafness Resulting from Genetic Mutation of Connexin 26
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Lee JY, In SI, Kim HJ, Jeong SY, Choung YH, Kim YC
- KMID: 2157865
- J Korean Med Sci.
- 2010 Oct;25(10):1539-1542.
- doi: 10.3346/jkms.2010.25.10.1539
Gap junctions, which mediate rapid intercellular communication, consist of connexins, small transmembrane proteins that belong to a large family of proteins found throughout the species. Mutations in the GJB2 gene,... -
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- The Efficacy of Connexin 43 Expression in the Myocardium as an Early Ischemic Marker in Forensic Autopsy
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Ahn JW, Huh GY
- KMID: 1785232
- Korean J Leg Med.
- 2015 Feb;39(1):6-11.
- doi: 10.7580/kjlm.2015.39.1.6
The postmortem diagnosis of ischemic heart disease is sometimes difficult for forensic pathologists especially when microscopic ischemic change in the myocardium is not detected at the early stages of ischemic... -
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- Apoptosis Progression in the Hair Cells in the Organ of Corti of GJB2 Conditional Knockout Mice
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Zhang Y, Zhang X, Li L, Sun Y, Sun J
- KMID: 2134595
- Clin Exp Otorhinolaryngol.
- 2012 Sep;5(3):132-138.
- doi: 10.3342/ceo.2012.5.3.132
OBJECTIVES: Apoptosis may play an important role in the mechanism underlying the GJB2 gene conditional knockout (cCx26) mice cochlear cell death. The objective of this study was to explore the... -
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- Role of Gap Junction in the Regulation of Renin Release and Intracellular Calcium in As 4.1 Cell Line
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Han JH, Hong BZ, Kwak YG, Yuan K, Park WH, Kim SZ, Kim SH
- KMID: 2285333
- Korean J Physiol Pharmacol.
- 2007 Jun;11(3):107-112.
Gap junction protein, connexin, is expressed in endothelial cells of vessels, glomerulus, and renin secreting cells of the kidney. The purpose of this study was to investigate the role of... -
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- In Silico Study of Human Gap Junction Beta-2 Protein by Homology Modeling
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Shehzadi A, Masood K
- KMID: 2166480
- Genomics Inform.
- 2010 Jun;8(2):70-75.
Asp66his, Asp54Lys, and Asp50Asn are mutations in connexin 26 that are observed in the clinic and give rise to autosomal dominant syndromes. They are the result of point mutations in... -
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- Non-syndromic hearing loss caused by the dominant cis mutation R75Q with the recessive mutation V37I of the GJB2 (Connexin 26) gene
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Kim J, Jung J, Lee MG, Choi JY, Lee KA
- KMID: 2155423
- Exp Mol Med.
- 2015 Jun;47(6):e169.
- doi: 10.1038/emm.2015.32
GJB2 alleles containing two cis mutations have been rarely found in non-syndromic hearing loss. Herein, we present a Korean patient with non-syndromic hearing loss caused by the R75Q cis mutation... -
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- Spatial relationship between expression of cytokeratin-19 and that of connexin-43 in human fetal kidney
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Hieda K, Hayashi S, Kim JH, Murakami G, Cho BH, Matsubara
- KMID: 2046755
- Anat Cell Biol.
- 2013 Mar;46(1):32-38.
- doi: 10.5115/acb.2013.46.1.32
Connexin-43, a major gap junction protein, and cytokeratin-19, one of the intermediate filament keratins, are known to be markers of well-differentiated epithelium. In this study, we investigated the expression of... -
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- Expression Pattern of Gap Junction Protein, Connexin 26 and 43 in Human Middle Ear Cholesteatomas
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Choung YH, Park K, Kang SO, Shin YR, Cho MJ, Yoon YR
- KMID: 2276545
- Korean J Otolaryngol-Head Neck Surg.
- 2006 Jan;49(1):29-34.
BACKGROUND AND OBJECTIVES: A human cholesteatoma in the middle ear is characterized by the presence of a keratinizing epithelium from hyperproliferative properties. It needs intercellular signal exchange through gap junctions... -
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