- Phenotypic Characterization of Ligamentum Flavum Cells from Patients with Ossification of Ligamentum Flavum
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Zhong ZM, Chen JT
- KMID: 1758565
- Yonsei Med J.
- 2009 Jun;50(3):375-379.
- doi: 10.3349/ymj.2009.50.3.375
PURPOSE: The objective of this study was to determine the phenotypic characterization of ligamentum flavum cells from patients with ossification of the ligamentum flavum (OLF). MATERIALS AND METHODS: Ligamentum flavum... -
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- Effects of Hepatocyte Growth Factor on Collagen Synthesis and Matrix Metalloproteinase Production in Keloids
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Lee WJ, Park SE, Rah DK
- KMID: 1777848
- J Korean Med Sci.
- 2011 Aug;26(8):1081-1086.
- doi: 10.3346/jkms.2011.26.8.1081
Keloids are pathologic proliferations of the dermal layer of the skin resulting from excessive collagen production and deposition. Hepatocyte growth factor (HGF) increases the expression of matrix metalloproteinase (MMP)-1 and... -
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- Osteogenesis Imperfecta Type VI with Severe Bony Deformities Caused by Novel Compound Heterozygous Mutations in SERPINF1
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Cho SY, Ki CS, Sohn YB, Kim SJ, Maeng SH, Jin DK
- KMID: 1777512
- J Korean Med Sci.
- 2013 Jul;28(7):1107-1110.
- doi: 10.3346/jkms.2013.28.7.1107
Osteogenesis imperfecta (OI) comprises a heterogeneous group of disorders characterized by bone fragility, frequent fractures, and low bone mass. Dominantly inherited COL1A1 or COL1A2 mutations appear to be causative in... -
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- Snapshot of degenerative aging of porcine intervertebral disc: a model to unravel the molecular mechanisms
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Cho H, Park SH, Lee S, Kang M, Hasty KA, Kim SJ
- KMID: 1107374
- Exp Mol Med.
- 2011 Jun;43(6):334-340.
- doi: 10.3858/emm.2011.43.6.036
Larger animal models, such as porcine, have been validated as appropriate models of the human disc with respect to biomechanics and biochemistry. They are advantageous for research as the models... -
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- Biologic Response of Degenerative Living Human Nucleus Pulposus Cells to Treatment with Cytokines
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Kim SH, Kuh SU, Kim KN, Park JY, Cho KH, Chin DK, Kim KS, Cho YE
- KMID: 2352817
- Yonsei Med J.
- 2015 Jan;56(1):277-286.
- doi: 10.3349/ymj.2015.56.1.277
PURPOSE: To investigate the molecular responses of various genes and proteins related to disc degeneration upon treatment with cytokines that affect disc-cell proliferation and phenotype in living human intervertebral discs... -
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- Oleuropein prevents the progression of steatohepatitis to hepatic fibrosis induced by a high-fat diet in mice
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Kim SW, Hur W, Li TZ, Lee YK, Choi JE, Hong SW, Lyoo KS, You CR, Jung ES, Jung CK, Park T, Um SJ, Yoon SK
- KMID: 2155357
- Exp Mol Med.
- 2014 Apr;46(4):e92.
- doi: 10.1038/emm.2014.10
Nonalcoholic steatohepatitis (NASH) is characterized by hepatocyte injury and inflammatory cell infiltration, which has been linked to peripheral insulin resistance and increased levels of triglycerides in the liver. The purposes... -
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- Metformin Reduces Bleomycin-induced Pulmonary Fibrosis in Mice
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Choi SM, Jang AH, Kim H, Lee KH, Kim YW
- KMID: 2468274
- J Korean Med Sci.
- 2016 Sep;31(9):1419-1425.
- doi: 10.3346/jkms.2016.31.9.1419
Metformin has anti-inflammatory and anti-fibrotic effects. We investigated whether metformin has an inhibitory effect on bleomycin (BLM)-induced pulmonary fibrosis in a murine model. A total of 62 mice were divided... -
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- Stimulating Effect of a Novel Synthesized Sulfonamido-Based Gallate ZXHA-TC on Primary Osteoblasts
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Jin P, Liao L, Lin X, Guo Q, Lin C, Wu H, Zheng L, Zhao J
- KMID: 2450351
- Yonsei Med J.
- 2015 May;56(3):760-771.
- doi: 10.3349/ymj.2015.56.3.760
PURPOSE: This study is intended to investigate the effects of plants or plant-derived antioxidants on prevention of osteoporosis through the maintenance of reactive oxygen species (ROS) at a favorable level. MATERIALS... -
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- Cyclooxygenase-2 inhibitors modulate skin aging in a catalytic activity-independent manner
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Lee ME, Kim SR, Lee S, Jung YJ, Choi SS, Kim WJ, Han JA
- KMID: 1389733
- Exp Mol Med.
- 2012 Sep;44(9):536-544.
It has been proposed that the pro-inflammatory catalytic activity of cyclooxygenase-2 (COX-2) plays a key role in the aging process. However, it remains unclear whether the COX-2 activity is a... -
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- Antifibrotic effects of magnesium lithospermate B on hepatic stellate cells and thioacetamide-induced cirrhotic rats
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Paik YH, Yoon YJ, Lee HC, Jung MK, Kang SH, Chung SI, Kim JK, Cho JY, Lee KS, Han KH
- KMID: 1107375
- Exp Mol Med.
- 2011 Jun;43(6):341-349.
- doi: 10.3858/emm.2011.43.6.037
Magnesium lithospermate B (MLB) is one of the major active components of Salvia miltiorrhizae. The anti-oxidative effects of Salvia miltiorrhizae have been previously reported. The aim of this study was... -
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