- Are You "Tilting at Windmills" or Undertaking a Valid Clinical Trial?
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Steeves JD, Zariffa J, Kramer JL
- KMID: 1108061
- Yonsei Med J.
- 2011 Sep;52(5):701-716.
- doi: 10.3349/ymj.2011.52.5.701
In this review, several aspects surrounding the choice of a therapeutic intervention and the conduct of clinical trials are discussed. Some of the background for why human studies have evolved... -
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- Review of the Registration in the Clinical Research Information Service
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Choi EK, Kim MJ, Lim NK, Park HY
- KMID: 2359984
- J Korean Med Sci.
- 2016 Jan;31(1):1-8.
- doi: 10.3346/jkms.2016.31.1.1
Clinical research registration is required in many countries to improve transparency of clinical research and to ensure subject safety. Developed in February 2010, the Clinical Research Information Service (CRIS) is... -
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- Expected Next-Generation Drugs Under Development in Relation to Voiding Symptoms
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Chung KJ, Chung BI
- KMID: 2387169
- Int Neurourol J.
- 2017 Jun;21(2):97-101.
- doi: 10.5213/inj.1734928.464
New drug development is a high-risk venture, but if successful, will bring great revenues to those willing to accept the risk. In the field of urology, in particular for lower... -
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- The potential use of mesenchymal stem cells in hematopoietic stem cell transplantation
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Kim EJ, Kim N, Cho SG
- KMID: 2154221
- Exp Mol Med.
- 2013 Jan;45(1):e2.
In the last 10 years, mesenchymal stem cells (MSCs) have emerged as a therapeutic approach to regenerative medicine, cancer, autoimmune diseases, and many more due to their potential to differentiate... -
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- Spinal Cord Injury and Related Clinical Trials
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Kim YH, Ha KY, Kim SI
- KMID: 2412297
- Clin Orthop Surg.
- 2017 Mar;9(1):1-9.
- doi: 10.4055/cios.2017.9.1.1
Spinal cord injury (SCI) has been considered an incurable condition and it often causes devastating sequelae. In terms of the pathophysiology of SCI, reducing secondary damage is the key to... -
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- Clinical Trials with Stem Cells in Digestive Diseases and Future Perspectives
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Kim TI
- KMID: 1018401
- Korean J Gastroenterol.
- 2011 Sep;58(3):139-143.
- doi: 10.4166/kjg.2011.58.3.139
Many techniques for isolation, expansion and handling of stem cells are being developed rapidly, and preclinical evidence has shown the possibility to use this technology for refractory diseases in the... -
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- Clinicoepidemiological research designs in childhood allergic diseases
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Yang HJ
- KMID: 2361280
- Allergy Asthma Respir Dis.
- 2016 Mar;4(2):91-99.
- doi: 10.4168/aard.2016.4.2.91
Clinical epidemiology is defined as a method for investigating the distribution and determinants of diseases and for applying this knowledge in their prevention, and simply means application of epidemiological methods... -
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- Non-alcoholic fatty liver diseases: update on the challenge of diagnosis and treatment
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Oh H, Jun DW, Saeed WK, Nguyen MH
- KMID: 2373132
- Clin Mol Hepatol.
- 2016 Sep;22(3):327-335.
- doi: 10.3350/cmh.2016.0049
The prevalence of non-alcoholic fatty liver disease (NAFLD) is estimated to be 25-30% of the population, and is the most common cause of elevated liver enzymes in Korea. NAFLD is... -
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- Effect of Brace to Osteoporotic Vertebral Fracture: a Meta-Analysis
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Jin YZ, Lee JH
- KMID: 2468257
- J Korean Med Sci.
- 2016 Oct;31(10):1641-1649.
- doi: 10.3346/jkms.2016.31.10.1641
Brace is one of the most commonly used interventions to manage osteoporotic vertebral fracture. However, its authentic effectiveness remains unclear. The aim of this study was to investigate the efficacy... -
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- Surgical manual of the Korean Gynecologic Oncology Group: classification of hysterectomy and lymphadenectomy
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Lee M, Choi CH, Chun YK, Kim YH, Lee KB, Lee SW, Shim SH, Song YJ, Roh JW, Chang SJ, Lee JM
- KMID: 2413852
- J Gynecol Oncol.
- 2017 Jan;28(1):e5.
- doi: 10.3802/jgo.2017.28.e5
The Surgery Treatment Modality Committee of the Korean Gynecologic Oncologic Group (KGOG) has determined to develop a surgical manual to facilitate clinical trials and to improve communication between investigators by... -
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- Integrating Evidence for Managing Asthma in Patients Who Smoke
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Price D, Bjermer L, Popov TA, Chisholm A
- KMID: 2260254
- Allergy Asthma Immunol Res.
- 2014 Mar;6(2):114-120.
- doi: 10.4168/aair.2014.6.2.114
Cigarette smoking among asthma patients is associated with worsening symptoms and accelerated decline in lung function. Smoking asthma is also characterized by increased levels of neutrophils and macrophages, and greater... -
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- The Role of Pharmacoethnicity in the Development of Cytotoxic and Molecular Targeted Drugs in Oncology
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Saijo N
- KMID: 1776911
- Yonsei Med J.
- 2013 Jan;54(1):1-14.
- doi: 10.3349/ymj.2013.54.1.1
The effective and toxic ranges of anticancer drugs are very narrow and, in some cases, inverted. Thus determination of the most appropriate dosage and schedule of administration is crucial for... -
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- Systematic Review and Meta-Analysis of Pulmonary Hypertension Specific Therapy for Exercise Capacity in Chronic Obstructive Pulmonary Disease
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Park J, Song JH, Park DA, Lee JS, Lee SD, Oh YM
- KMID: 1793026
- J Korean Med Sci.
- 2013 Aug;28(8):1200-1206.
- doi: 10.3346/jkms.2013.28.8.1200
Some patients with chronic obstructive pulmonary disease (COPD) have pulmonary hypertension (PH) that adversely affects survival. We performed a systematic review and meta-analysis to assess whether PH-specific therapies have an... -
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- Neurorestoration Induced by Mesenchymal Stem Cells: Potential Therapeutic Mechanisms for Clinical Trials
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Seo JH, Cho SR
- KMID: 1414244
- Yonsei Med J.
- 2012 Nov;53(6):1059-1067.
- doi: 10.3349/ymj.2012.53.6.1059
Stem cells are emerging as therapeutic candidates in a variety of diseases because of their multipotent capacities. Among these, mesenchymal stem cells (MSCs) derived from bone marrow, umbilical cord blood... -
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- Effects of Dignity Interventions on Psychosocial and Existential Distress in Terminally ill Patients: A Meta-analysis
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Oh PJ, Shin SR
- KMID: 2129537
- J Korean Acad Nurs.
- 2014 Oct;44(5):471-483.
- doi: 10.4040/jkan.2014.44.5.471
PURPOSE: This study was done to evaluate the effects of dignity interventions on depression, anxiety and meaning of life in terminally ill patients. METHODS: PubMed, Cochrane Library CENTRAL, EMBASE, CINAHL and... -
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- Research on Endemic Diseases and Japanese Colonial Rule: Focusing on the Emetine Poisoning Accident in Yeongheung and Haenam Counties in 1927
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Sihn KH
- KMID: 1070698
- Korean J Med Hist.
- 2009 Dec;18(2):173-188.
This paper aims to examine the spread of paragonimiasis and the Japanese colonial government's response to it. To consolidate colonial rule, the Japanese colonial government needed medications to cure paragonimiasis.... -
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- Golimumab Therapy in Ulcerative Colitis
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Moon W
- KMID: 2383543
- Korean J Gastroenterol.
- 2016 Feb;67(2):64-73.
- doi: 10.4166/kjg.2016.67.2.64
Ulcerative colitis is a chronic inflammatory condition of the colon, characterized by diffuse mucosal inflammation and blood-mixed diarrhea. The main treatment has been 5-aminosalicylic acid, steroid, thiopurine, and anti-tumor necrosis... -
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- Insulin Initiation in Insulin-Naive Korean Type 2 Diabetic Patients Inadequately Controlled on Oral Antidiabetic Drugs in Real-World Practice: The Modality of Insulin Treatment Evaluation Study
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Kim SS, Kim IJ, Kim YK, Yoon KH, Son HY, Park SW, Sung YA, Baek HS
- KMID: 2174000
- Diabetes Metab J.
- 2015 Dec;39(6):481-488.
- doi: 10.4093/dmj.2015.39.6.481
BACKGROUND: The Modality of Insulin Treatment Evaluation (MOTIV) study was performed to provide real-world data concerning insulin initiation in Korean type 2 diabetes mellitus (T2DM) patients with inadequate glycemic control... -
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- The Effectiveness of Recombinant Human Thyroid-Stimulating Hormone versus Thyroid Hormone Withdrawal Prior to Radioiodine Remnant Ablation in Thyroid Cancer: A Meta-Analysis of Randomized Controlled Trials
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Pak K, Cheon GJ, Kang KW, Kim SJ, Kim IJ, Kim EE, Lee DS, Chung JK
- KMID: 1796944
- J Korean Med Sci.
- 2014 Jun;29(6):811-817.
- doi: 10.3346/jkms.2014.29.6.811
We evaluated the efficacy of recombinant human thyroid-stimulating hormone (rhTSH) versus thyroid hormone withdrawal (THW) prior to radioiodine remnant ablation (RRA) in thyroid cancer. A systematic search of MEDLINE, EMBASE,... -
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- Effect of Kegel Exercise to Prevent Urinary and Fecal Incontinence in Antenatal and Postnatal Women: Systematic Review
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Park SH, Kang CB, Jang SY, Kim BY
- KMID: 1707132
- J Korean Acad Nurs.
- 2013 Jun;43(3):420-430.
- doi: 10.4040/jkan.2013.43.3.420
PURPOSE: The aim of this study was to review the literature to determine whether intensive pelvic floor muscle training during pregnancy and after delivery could prevent urinary and fecal incontinence. METHODS:... -
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