- Letter to the Editor: Antiproliferation and Redifferentiation in Thyroid Cancer Cell Line by Polyphenol Phytochemicals
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Kim TY
- KMID: 1786003
- J Korean Med Sci.
- 2011 Oct;26(10):1397-1397.
- doi: 10.3346/jkms.2011.26.10.1397
No abstract available. -
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- Neural cell adhesion molecule (NCAM) promotes the differentiation of hippocampal precursor cells to a neuronal lineage, especially to a glutamatergic neural cell type
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Shin MH, Lee EG, Lee SH, Lee YS, Son H
- KMID: 1121093
- Exp Mol Med.
- 2002 Dec;34(6):401-410.
Rat hippocampal precursor cells isolated from hippocampi of embryonic day 16.5 (E16.5) rat embryos were found to proliferate in the presence of basic fibroblast growth factor. Addition of soluble... -
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- Suppression of MicroRNA let-7a Expression by Agmatine Regulates Neural Stem Cell Differentiation
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Song J, Oh Y, Kim JY, Cho KJ, Lee JE
- KMID: 2427165
- Yonsei Med J.
- 2016 Nov;57(6):1461-1467.
- doi: 10.3349/ymj.2016.57.6.1461
PURPOSE: Neural stem cells (NSCs) effectively reverse some severe central nervous system (CNS) disorders, due to their ability to differentiate into neurons. Agmatine, a biogenic amine, has cellular protective effects... -
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- Reactive oxygen species enhance differentiation of human embryonic stem cells into mesendodermal lineage
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Ji AR, Ku SY, Cho MS, Kim YY, Kim YJ, Oh SK, Kim SH, Moon SY, Choi YM
- KMID: 946650
- Exp Mol Med.
- 2010 Mar;42(3):175-186.
- doi: 10.3858/emm.2010.42.3.018
Recently, reactive oxygen species (ROS) have been studied as a regulator of differentiation into specific cell types in embryonic stem cells (ESCs). However, ROS role in human ESCs (hESCs) is... -
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- Dexamethasone-induced differentiation of pancreatic AR42J cell involves p21(waf1/cip1)and MAP kinase pathway
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Eum WS, Li MZ, Sin GS, Choi SY, Park JB, Lee JY, Kwon HY
- KMID: 1093610
- Exp Mol Med.
- 2003 Oct;35(5):379-384.
Dexamethasone converts pluripotent pancreatic AR42J cells into exocrine cells expressing digestive enzymes. In order to address molecular mechanism of this differentiation, we have investigated the role of mitogen-activated protein (MAP)... -
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- Dual-Blocking of PI3K and mTOR Improves Chemotherapeutic Effects on SW620 Human Colorectal Cancer Stem Cells by Inducing Differentiation
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Kim MJ, Koo JE, Han GY, Kim B, Lee YS, Ahn C, Kim CW
- KMID: 2363495
- J Korean Med Sci.
- 2016 Mar;31(3):360-370.
- doi: 10.3346/jkms.2016.31.3.360
Cancer stem cells (CSCs) have tumor initiation, self-renewal, metastasis and chemo-resistance properties in various tumors including colorectal cancer. Targeting of CSCs may be essential to prevent relapse of tumors after... -
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- Activated protein C differentially regulates both viability and differentiation of osteoblasts mediated by bisphosphonates
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Lee YJ, Jeong JK, Seol JW, Xue M, Jackson C, Park SY
- KMID: 2154228
- Exp Mol Med.
- 2013 Feb;45(2):e9.
Activated protein C (APC) is a cytoprotective anticoagulant that can promote cutaneous healing. We examined the effect of APC on viability and differentiation of the osteoblastic line, MG63, in the... -
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- B cells activated in the presence of Th1 cytokines inhibit osteoclastogenesis
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Choi Y, Kim JJ
- KMID: 1093611
- Exp Mol Med.
- 2003 Oct;35(5):385-392.
Host immune response has been considered as an important disease-modifying factor of periodontitis, however, which immune cell(s) or factor(s) are involved in the destruction of periodontium remains unclear. Previously, we... -
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- Msx2 mediates the inhibitory action of TNF-alpha on osteoblast differentiation
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Lee HL, Yi T, Woo KM, Ryoo HM, Kim GS, Baek JH
- KMID: 1078359
- Exp Mol Med.
- 2010 Jun;42(6):437-445.
- doi: 10.3858/emm.2010.42.6.045
TNF-alpha, a proinflammatory cytokine, inhibits osteoblast differentiation under diverse inflammatory conditions; however, the underlying mechanisms in terms of the TNF-alpha signaling pathway remain unclear. In this study, we examined the... -
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- Staurosporine and cytochalasin D induce chondrogenesis by regulation of actin dynamics in different way
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Kim M, Song K, Jin EJ, Sonn J
- KMID: 1389731
- Exp Mol Med.
- 2012 Sep;44(9):521-528.
Actin cytoskeleton has been known to control and/or be associated with chondrogenesis. Staurosporine and cytochalasin D modulate actin cytoskeleton and affect chondrogenesis. However, the underlying mechanisms for actin dynamics regulation... -
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- The Effect of Simvastatin on the Proliferation and Differentiation of Human Bone Marrow Stromal Cells
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Baek KH, Lee WY, Oh KW, Tae HJ, Lee JM, Lee EJ, Han JH, Kang MI, Cha BY, Lee KW, Son HY, Kang SK
- KMID: 1778503
- J Korean Med Sci.
- 2005 Jun;20(3):438-444.
- doi: 10.3346/jkms.2005.20.3.438
Statins have been postulated to affect the bone metabolism. Recent experimental and epidemiologic studies have suggested that statins may also have bone protective effects. This study assessed the effects of... -
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- Tanshinone IIA inhibits osteoclast differentiation through down-regulation of c-Fos and NFATc1
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Kwak HB, Yang D, Ha H, Lee JH, Kim HN, Woo ER, Lee S, Kim HH, Lee ZH
- KMID: 1094151
- Exp Mol Med.
- 2006 Jun;38(3):256-264.
Bone is a dynamic tissue that is regulated by the activity of bone-resorbing osteoclasts and bone-forming osteoblasts. Excessive osteoclast formation causes diseases such as osteoporosis and rheumatoid arthritis. Natural substances... -
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- Euodia sutchuenensis Dode extract stimulates osteoblast differentiation via Wnt/beta-catenin pathway activation
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Hwang JH, Cha PH, Han G, Bach TT, Min DS, Choi KY
- KMID: 2155417
- Exp Mol Med.
- 2015 Mar;47(3):e152.
- doi: 10.1038/emm.2014.115
The Wnt/beta-catenin pathway has a role in osteoblast differentiation and bone formation. We screened 100 plant extracts and identified an extract from Euodia sutchuenensis Dode (ESD) leaf and young branch... -
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- Dexamethasone differentiates NG108-15 cells through cyclooxygenase1 induction
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Kim HS, Song M, Kim E, Ryu SH, Suh PG
- KMID: 1094702
- Exp Mol Med.
- 2003 Jun;35(3):203-210.
Cyclooxygenase (COX) is a key enzyme in the conversion of arachidonic acid into prostanoids which participate in various cellular functions including apoptosis, mitogenesis, inflammation, immune modulation and differentiation. Moreover, the... -
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- Toxic effects of methylmercury, arsanilic acid and danofloxacin on the differentiation of mouse embryonic stem cells into neural cells
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Kang SJ, Jeong SH, Kim EJ, Park YI, Park SW, Shin HS, Son SW, Kang HG
- KMID: 1737611
- J Vet Sci.
- 2014 Mar;15(1):61-71.
- doi: 10.4142/jvs.2014.15.1.61
This study was performed to assess the neurotoxic effects of methylmercury, arsanilic acid and danofloxacin by quantification of neural-specific proteins in vitro. Quantitation of the protein markers during 14 days... -
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- NF-kappaB is involved in the TNF-alpha induced inhibition of the differentiation of 3T3-L1 cells by reducing PPARg expression
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Chae GN, Kwak SJ
- KMID: 1093616
- Exp Mol Med.
- 2003 Oct;35(5):431-437.
TNF-alpha, a trimeric cytokine, was known to inhibit differention of preadipocytes to adipocytes. In the present study, we investigated signal mediators working downstream of TNF-alpha using murine 3T3-L1 cells. TNF-alpha... -
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- TiO2 nanotube stimulate chondrogenic differentiation of limb mesenchymal cells by modulating focal activity
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Kim D, Choi B, Song J, Kim S, Oh S, Jin EH, Kang SS, Jin EJ
- KMID: 1022120
- Exp Mol Med.
- 2011 Aug;43(8):455-461.
- doi: 10.3858/emm.2011.43.8.051
Vertically aligned, laterally spaced nanoscale titanium nanotubes were grown on a titanium surface by anodization, and the growth of chondroprogenitors on the resulting surfaces was investigated. Surfaces bearing nanotubes of... -
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- Antiproliferation and Redifferentiation in Thyroid Cancer Cell Lines by Polyphenol Phytochemicals
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Kang HJ, Youn YK, Hong MK, Kim LS
- KMID: 1094260
- J Korean Med Sci.
- 2011 Jul;26(7):893-899.
- doi: 10.3346/jkms.2011.26.7.893
Thyroid carcinogenesis is accompanied by loss of thyroid-specific functions and refractory to radioiodine and thyroid stimulating hormone (TSH) suppression therapy. Redifferentiating agents have been shown to inhibit tumor growth and... -
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- Simvastatin inhibits sphingosylphosphorylcholine-induced differentiation of human mesenchymal stem cells into smooth muscle cells
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Kim KH, Kim YM, Lee MJ, Ko HC, Kim MB, Kim JH
- KMID: 1120134
- Exp Mol Med.
- 2012 Feb;44(2):159-166.
- doi: 10.3858/emm.2012.44.2.011
Sphingosylphosphorylcholine (SPC) induces differentiation of human adipose tissue-derived mesenchymal stem cells (hASCs) into smooth muscle-like cells expressing alpha-smooth muscle actin (alpha-SMA) via transforming growth factor-beta1/Smad2- and RhoA/Rho kinase-dependent mechanisms. 3-Hydroxy-3-methylglutaryl-coenzyme... -
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- Cell proliferation and neuroblast differentiation in the dentate gyrus of high-fat diet-fed mice are increased after rosiglitazone treatment
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Yoo DY, Kim W, Kim DW, Nam SM, Jung HY, Kim JW, Lee CH, Choi JH, Won MH, Yoon YS, Hwang IK
- KMID: 1737607
- J Vet Sci.
- 2014 Mar;15(1):27-33.
- doi: 10.4142/jvs.2014.15.1.27
In this study, we determined how rosiglitazone (RSG) differentially affected hippocampal neurogenesis in mice fed a low-fat diet (LFD) or high-fat diet (HFD; 60% fat). LFD and HFD were given... -
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