- IL-1beta Acts in Synergy with Endogenous IL-1beta in A375-S2 Human Melanoma Cell Apoptosis Through Mitochondrial Pathway
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Wang C, Wang MW, Tashiro SI, Onodera S, Ikejima T
- KMID: 1712732
- J Korean Med Sci.
- 2005 Aug;20(4):555-561.
- doi: 10.3346/jkms.2005.20.4.555
Interleukin-1beta (IL-1beta) is a pivotal proinflammatory cytokine. To investigate the mechanism of IL-1beta-induced cell death in human malignant melanoma A375-S2 cells, MTT assay, photomicroscopical observation, DNA agarose gel electrophoresis, radioimmunoassay... -
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- Cilostazol Protects Endothelial Cells Against Lipopolysaccharide-Induced Apoptosis Through ERK1/2- and P38 MAPK-Dependent Pathways
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Lim JH, Woo JS, Shin YW
- KMID: 1717961
- Korean J Intern Med.
- 2009 Jun;24(2):113-122.
- doi: 10.3904/kjim.2009.24.2.113
BACKGROUND/AIMS: We examined the effects of cilostazol on mitogen-activated protein kinase (MAPK) activity and its relationship with cilostazol-mediated protection against apoptosis in lipopolysaccharide (LPS)-treated endothelial cells. METHODS: Human umbilical vein... -
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- IL-10 Mediates Rosiglitazone-Induced Kidney Protection in Cisplatin Nephrotoxicity
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Kim MG, Yang HN, Kim HW, Jo SK, Cho WY, Kim HK
- KMID: 1792925
- J Korean Med Sci.
- 2010 Apr;25(4):557-563.
- doi: 10.3346/jkms.2010.25.4.557
Cisplatin, a major anti-neoplastic drug, is known to be nephrotoxic and inflammation-inducing. A peroxisome proliferator-activated receptor gamma agonist, regulating lipid metabolism, has known to have anti-inflammatory effect, but the protection... -
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- Cytochrome C-dependent Fas-independent apoptotic pathway in HeLa cells induced by delta12-prostaglandin J2
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Kim BE, Roh SR, Kim JW, Jeong SW, Kim IK
- KMID: 1109319
- Exp Mol Med.
- 2003 Aug;35(4):293-300.
Cyclopentenone prostaglandins (PGs) have antiproliferative activity on various tumor cell growth in vitro. Particularly, 9-deoxy-(9,12)-13,14-dihydro PGD2( delta12-PGJ2) was reported for its antineoplastic and apoptotic effects on various cancer cells, but... -
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- Tanshinone IIA, an ingredient of Salvia miltiorrhiza BUNGE, induces apoptosis in human leukemia cell lines through the activation of caspase-3
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Sung HJ, Choi SM, Yoon YS, An KS
- KMID: 1029923
- Exp Mol Med.
- 1999 Dec;31(4):174-178.
Tanshinone II-A is a derivative of phenanthrene-quinone isolated from Salvia miltiorrhiza BUNGE, a traditional herbal medicine that is known to induce antiinflammatory, anti-oxidative and cytotoxic activity. We have... -
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- Amoebic PI3K and PKC Is Required for Jurkat T Cell Death Induced by Entamoeba histolytica
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Lee YA, Kim KA, Min A, Shin MH
- KMID: 1792196
- Korean J Parasitol.
- 2014 Aug;52(4):355-365.
- doi: 10.3347/kjp.2014.52.4.355
The enteric protozoan parasite Entamoeba histolytica is the causative agent of human amebiasis. During infection, adherence of E. histolytica through Gal/GalNAc lectin on the surface of the amoeba can induce... -
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- Activated protein C differentially regulates both viability and differentiation of osteoblasts mediated by bisphosphonates
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Lee YJ, Jeong JK, Seol JW, Xue M, Jackson C, Park SY
- KMID: 2154228
- Exp Mol Med.
- 2013 Feb;45(2):e9.
Activated protein C (APC) is a cytoprotective anticoagulant that can promote cutaneous healing. We examined the effect of APC on viability and differentiation of the osteoblastic line, MG63, in the... -
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- Cadmium induces apoptosis in primary rat osteoblasts through caspase and mitogen-activated protein kinase pathways
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Zhao H, Liu W, Wang Y, Dai N, Gu J, Yuan Y, Liu X, Bian J, Liu ZP
- KMID: 2344302
- J Vet Sci.
- 2015 Sep;16(3):297-306.
- doi: 10.4142/jvs.2015.16.3.297
Exposure to cadmium (Cd) induces apoptosis in osteoblasts (OBs); however, little information is available regarding the specific mechanisms of Cd-induced primary rat OB apoptosis. In this study, Cd reduced cell... -
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- Cell-free expression and functional reconstitution of CALM in clathrin assembly
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Kim JA, Kim HL
- KMID: 1085745
- Exp Mol Med.
- 2001 Jun;33(2):89-94.
Clathrin-mediated vesicle formation is an essential step in the intracellular trafficking of the protein and lipid. Binding of clathrin assembly protein to clathrin triskelia induces their assembly into clathrin-coated vesicles... -
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- CD43 cross-linking increases the Fas-induced apoptosis through induction of Fas aggregation in Jurkat T-cells
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Kim HJ, Park HJ, Park WS, Bae Y
- KMID: 1110119
- Exp Mol Med.
- 2006 Aug;38(4):357-363.
CD43 (sialophorin, leukosialin) is a heavily sialylated surface protein expressed on most leukocytes and platelets including T cells. Although CD43 antigen is known to have multiple and complex structure, exact... -
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- Antigen-binding Characteristics of Circulating IgG Autoantibodies to Cytokeratin 18 Protein in Patients with Nonallergic Asthma
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Yim H, Kim JE, Shin JY, Ye YM, Park HS, Nahm DH
- KMID: 2157816
- J Korean Med Sci.
- 2006 Aug;21(4):652-655.
- doi: 10.3346/jkms.2006.21.4.652
Cytokeratin 18 (CK18) protein was identified as an airway epithelial cell autoantigen associated with nonallergic asthma. Cleavage of CK18 protein by caspase-3 is a marker of early apoptosis in epithelial... -
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- Methylglyoxal Induces Apoptosis Mediated by Reactive Oxygen Species in Bovine Retinal Pericytes
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Kim J, Son JW, Lee JA, Oh YS, Shinn SH
- KMID: 1785701
- J Korean Med Sci.
- 2004 Feb;19(1):95-100.
- doi: 10.3346/jkms.2004.19.1.95
One of the histopathologic hallmarks of early diabetic retinopathy is the loss of pericytes. Evidences suggest that the pericyte loss in vivo is mediated by apoptosis. However, the underlying cause... -
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- Caffeine Induces Apoptosis in Human Neuroblastoma Cell Line SK-N-MC
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Jang MH, Shin MC, Kang IS, Baik HH, Cho YH, Chu JP, Kim EH, Kim CJ
- KMID: 1127262
- J Korean Med Sci.
- 2002 Oct;17(5):674-678.
- doi: 10.3346/jkms.2002.17.5.674
Caffeine is one of the most widely consumed neuroactive drugs, coming mostly from everyday beverages such as coffee and tea. To investigate whether caffeine induces apoptosis in the central... -
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- Up-regulation of Bax and endonuclease G, and down-modulation of Bcl-X(L) involved in cardiotoxin III-induced apoptosis in K562 cells
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Yang SH, Chien CM, Lu MC, Lin YH, Hu XW, Lin SR
- KMID: 1110128
- Exp Mol Med.
- 2006 Aug;38(4):435-444.
Cardiotoxin III (CTX III), a basic polypeptide with 60 amino acid residues isolated from Naja naja atra venom, has been reported to have anticancer activity. CTX III-induced K562 cell apoptosis... -
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- Cap-independent protein translation is initially responsible for 4-(N-methylnitrosamino)-1-(3-pyridyl)-butanone (NNK)-induced apoptosis in normal human bronchial pithelial cells
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Moon SH, Kim HW, Kim JS, Park JH, Kim H, Eu GJ, Cho HS, Kang GM, Lee KH, Cho MH
- KMID: 1093633
- J Vet Sci.
- 2004 Dec;5(4):369-378.
Evidences show that eukaryotic mRNAs can perform protein translation through internal ribosome entry sites (IRES). 5'-Untranslated region of the mRNA encoding apoptotic protease-activating factor 1 (Apaf-1) contains IRES, and, thus,... -
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- Transglutaminase 2 inhibits apoptosis induced by calciumoverload through down-regulation of Bax
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Cho SY, Lee JH, Bae HD, Jeong EM, Jang GY, Kim CW, Shin DM, Jeon JH, Kim IG
- KMID: 983956
- Exp Mol Med.
- 2010 Sep;42(9):639-650.
- doi: 10.3858/emm.2010.42.9.063
An abrupt increase of intracellular Ca2+ is observed in cells under hypoxic or oxidatively stressed conditions. The dysregulated increase of cytosolic Ca2+ triggers apoptotic cell death through mitochondrial swelling and... -
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- HPV E6 antisense induces apoptosis in CaSki cells via suppression of E6 splicing
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Cho CW, Poo H, Cho YS, Cho MC, Lee KA, Lee SJ, Park SN, Kim IK, Jung YK, Choe YK, Yeom YI, Choe IS, Yoon DY
- KMID: 1081466
- Exp Mol Med.
- 2002 May;34(2):159-166.
Cervical cancer is known to be highly associated with viral oncogene E6 and E7 of human papilloma virus. Down-regulation of oncogene expression by antisense-based gene therapy has been extensively studied.... -
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- Delay of Photoreceptor Cell Degeneration in rd Mice by Systemically Administered Phenyl-N-tert-butylnitrone
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Kim JH, Kim JH, Yu YS, Jeong SM, Kim KW
- KMID: 754441
- Korean J Ophthalmol.
- 2005 Dec;19(4):288-292.
- doi: 10.3341/kjo.2005.19.4.288
PURPOSE: To study the effect of systemic administration of phenyl-N-tert-butylnitrone (PBN) on the degeneration of photoreceptor cells in rd mice. METHODS: PBN was injected intraperitoneally into FVB/rd mice on postnatal... -
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- Role of Ca(2+) in diallyI disulfide-induced apoptotic cell death of HCT-15 cells.
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Park EK, Kwon KB, Park KI, Park BH, Jhee EC
- KMID: 1380234
- Exp Mol Med.
- 2002 Jul;34(3):250-257.
Diallyl disulfide (DADS) induced apoptosis through the caspase-3 dependent pathway in leukemia cells was earlier reported from this laboratory. In this study, we investigated the involvement of Ca(2+) in DADS-induced... -
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- Enhancement of radiosensitivity by combined ceramide and dimethylsphingosine treatment in lung cancer cells
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Park HW, Song JY, Kim KS, Han Y, Kim CW, Yi SY, Yun YS
- KMID: 1123762
- Exp Mol Med.
- 2004 Oct;36(5):411-419.
Ceramide generated from sphingomyelin in response to ionizing radiation has been implicated as a second messenger to induce cellular proapoptotic signals. Both ceramide and its metabolic inhibitor, N, N-dimethyl-D-erythro-sphingosine (DMS),... -
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