- Molecules and their functions in autophagy
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Pyo JO, Nah J, Jung YK
- KMID: 1120125
- Exp Mol Med.
- 2012 Feb;44(2):73-80.
- doi: 10.3858/emm.2012.44.2.029
Autophagy is a self-degradation system of cellular components through an autophagosomal-lysosomal pathway. Over the last 15 yr, yeast genetic screens led to the identification of a number of genes involved... -
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- RING Finger Proteins Are Involved in the Progression of Barrett Esophagus to Esophageal Adenocarcinoma: A Preliminary Study
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Wang XW, Wei W, Wang WQ, Zhao XY, Guo H, Fang DC
- KMID: 2070058
- Gut Liver.
- 2014 Sep;8(5):487-494.
- doi: 10.5009/gnl13133
BACKGROUND/AIMS: To investigate the differential expression of RING finger (RNF) proteins in Barrett esophagus (BE) and esophageal adenocarcinoma (EAC). METHODS: The differential expression of RNFs in normal esophagus (NE), BE, and... -
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- NRAMP1 gene polymorphisms in patients with rheumatoid arthritis in Koreans
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Yang YS, Kim SJ, Kim JW, Koh EM
- KMID: 1731240
- J Korean Med Sci.
- 2000 Feb;15(1):83-87.
- doi: 10.3346/jkms.2000.15.1.83
Natural resistance-associated macrophage protein 1 (Nramp1) is a genetic locus associated with innate resistance or susceptibility of murine hosts to infection with intracellular pathogens such as Salmonella, Leishmania and Mycobacterium.... -
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- Hereditary Pancreatitis
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Kim YT
- KMID: 2439750
- Korean J Gastroenterol.
- 2005 Feb;45(2):143-147.
Hereditary pancreatitis (HP) is an autosomal dominant inherited disease characterized by recurrent episodes of pancreatitis often beginning in childhood, a family history of at least 2 other affected members, and... -
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- Dendritic eIF4E-binding Protein 1 (eIF4E-BP1) mRNA Is Upregulated by Neuronal Activation
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Moon IS, Lee HJ, Park IS
- KMID: 1778833
- J Korean Med Sci.
- 2012 Oct;27(10):1241-1247.
- doi: 10.3346/jkms.2012.27.10.1241
Long-term synaptic plasticity requires addition of new proteins at the synaptic site. The local protein synthesis at subsynaptic sites confers advantageous mechanisms that would regulate the protein composition in local... -
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- Two Siblings with Adolescent/Adult Onset Niemann-Pick Disease Type C in Korea
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Lee SY, Lee HJ, Kim SH, Jeong YJ, Jin HK, Bae JS, Cheon SM, Kim JW
- KMID: 2373740
- J Korean Med Sci.
- 2016 Jul;31(7):1168-1172.
- doi: 10.3346/jkms.2016.31.7.1168
Niemann-Pick disease, type C (NP-C), is caused by NPC1 or NPC2 gene mutations. Progressive neurological, psychiatric, and visceral symptoms are characteristic. Here, we present cases of a brother (Case 1)... -
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- Early Screening of Oxacillin-Resistant Staphylococcus aureus and Staphylococcus epidermidis from Blood Culture
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Jeong J, Chang CL, Park TS, Lee SH, Kim SR, Jeong SH
- KMID: 648671
- J Korean Med Sci.
- 2002 Apr;17(2):168-172.
- doi: 10.3346/jkms.2002.17.2.168
The timely detection of blood-borne pathogens is one of the most important functions of the microbiology laboratory. Recently, methicillin-resistant staphylococci have become the most important pathogens seen by the laboratory.... -
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- Is Whole Exome Sequencing Clinically Practical in the Management of Pediatric Crohn's Disease?
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Oh SH, Baek J, Kim KM, Lee EJ, Jung Y, Lee YJ, Jin HS, Ye BD, Yang SK, Lee JK, Seo EJ, Lim HT, Lee I, Song K
- KMID: 2377935
- Gut Liver.
- 2015 Nov;9(6):767-775.
- doi: 10.5009/gnl15176
BACKGROUND/AIMS: The aim of this study was to identify the profile of rare variants associated with Crohn's disease (CD) using whole exome sequencing (WES) analysis of Korean children with CD... -
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- Leukotriene-related Gene Polymorphisms in Patients with Aspirin-intolerant Urticaria and Aspirin-intolerant Asthma: Differing Contributions of ALOX5 Polymorphism in Korean Population
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Kim SH, Choi JH, Holloway J, Suh CH, Nahm DH, Ha EH, Park CS, Park HS
- KMID: 2157738
- J Korean Med Sci.
- 2005 Dec;20(6):926-931.
- doi: 10.3346/jkms.2005.20.6.926
The pathogenesis of aspirin (acetylsalicylic acid, ASA)-intolerant urticaria (AIU) is still poorly understood but it has recently been suggested that it is associated with the overproduction of leukotriene (LT). This... -
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- Aberrant Hypomethylation of Solute Carrier Family 6 Member 12 Promoter Induces Metastasis of Ovarian Cancer
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Sung HY, Yang SD, Park AK, Ju W, Ahn JH
- KMID: 2374185
- Yonsei Med J.
- 2017 Jan;58(1):27-34.
- doi: 10.3349/ymj.2017.58.1.27
PURPOSE: Ovarian cancer (OC) is the most fatal of gynecological malignancies with a high rate of recurrence. We aimed to evaluate the expression of solute carrier family 6, member 12... -
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- Association of the dopamine transporter gene with Parkinson's disease in Korean patients
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Kim JW, Kim DH, Kim SH, Cha JK
- KMID: 1730643
- J Korean Med Sci.
- 2000 Aug;15(4):449-451.
- doi: 10.3346/jkms.2000.15.4.449
Dopamine transporters (DAT) uptake neurotoxic substances such as 1-methyl-4-phenylpyridinium (MPP) in the dopaminergic nerve terminals and may confer susceptibility to cytotoxic effects of neurotoxic substance. The association of a variable... -
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- Tanshinone IIA inhibits osteoclast differentiation through down-regulation of c-Fos and NFATc1
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Kwak HB, Yang D, Ha H, Lee JH, Kim HN, Woo ER, Lee S, Kim HH, Lee ZH
- KMID: 1094151
- Exp Mol Med.
- 2006 Jun;38(3):256-264.
Bone is a dynamic tissue that is regulated by the activity of bone-resorbing osteoclasts and bone-forming osteoblasts. Excessive osteoclast formation causes diseases such as osteoporosis and rheumatoid arthritis. Natural substances... -
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- Novel Combination Markers for Predicting Survival in Patients with Muscle Invasive Bladder Cancer: USP18 and DGCR2
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Kim YH, Kim WT, Jeong P, Ha YS, Kang HW, Yun SJ, Moon SK, Choi YH, Kim IY, Kim WJ
- KMID: 1734921
- J Korean Med Sci.
- 2014 Mar;29(3):351-356.
- doi: 10.3346/jkms.2014.29.3.351
We performed gene expression profiling in bladder cancer patients to identify cancer-specific survival-related genes in muscle invasive bladder cancer (MIBC) patients. Sixty-two patients with MIBC were selected as the original... -
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- Analysis of Acquired Resistance Genes in Stenotrophomonas maltophilia
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Song JH, Sung JY, Kwon KC, Park JW, Cho HH, Shin SY, Ko YH, Kim JM, Shin KS, Koo SH
- KMID: 1781630
- Korean J Lab Med.
- 2010 Jun;30(3):295-300.
- doi: 10.3343/kjlm.2010.30.3.295
BACKGROUND: Stenotrophomonas maltophilia is a gram-negative bacillus and a nosocomial pathogen in immunocompromised patients. Trimethoprim/sulfamethoxazole (TMP/SMX) is the drug of choice for treating S. maltophilia infection; however, resistance to TMP/SMX... -
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- Potential Role of Homer-2a on Cutaneous Vascular Anomaly
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Kim JT, Park SH, Kim SK, Kwon EY, Do MH, Hwang TH
- KMID: 1127255
- J Korean Med Sci.
- 2002 Oct;17(5):636-640.
- doi: 10.3346/jkms.2002.17.5.636
Homer protein was identified based on its rapid induction in rat hippocampal granule cell neurons following excitatory synaptic activity. Although the presence of the Homer gene in the peripheral... -
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- Atrophy of brown adipocytes in the adult mouse causes transformation into white adipocyte-like cells
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Kim DW, Kim BS, Kwon HS, Kim CG, Lee HW, Choi WH, Kim CG
- KMID: 1119333
- Exp Mol Med.
- 2003 Dec;35(6):518-526.
Adipose tissue is an important endocrine regulator of glucose metabolism and energy homeostasis. Researches have focused on this tissue not only as a target for pharmacotherapy of obesity and insulin... -
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- Antiobesity activity of a sphingosine 1-phosphate analogue FTY720 observed in adipocytes and obese mouse model
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Moon MH, Jeong JK, Lee JH, Park YG, Lee YJ, Seol JW, Park SY
- KMID: 1506224
- Exp Mol Med.
- 2012 Oct;44(10):603-614.
Higher levels of body fat are associated with an increased risk for development numerous adverse health conditions. FTY720 is an immune modulator and a synthetic analogue of sphingosine 1-phosphate (S1P),... -
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- Human hepatocellular carcinoma cells resist to TRAIL-induced apoptosis, and the resistance is abolished by cisplatin
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Shin EC, Seong YR, Kim CH, Kim H, Ahn YS, Kim K, Kim SJ, Hong SS, Park JH
- KMID: 1081460
- Exp Mol Med.
- 2002 May;34(2):114-122.
TNF-related apoptosis-inducing ligand (TRAIL), a member of the TNF family, selectively induce apoptosis in various transformed cell lines but not in almost-normal tissues. It is regulated by 2 death receptors,... -
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