- Hypoxia in Hepatocellular Carcinoma
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Myung SJ, Yoon JH
- KMID: 760700
- Korean J Hepatol.
- 2007 Mar;13(1):9-19.
Hepatocellular carcinoma (HCC) is characterized by hypervascularity, indicating that angiogenesis plays a vital role in HCC growth and progression. A number of anti-angiogenic therapies are being utilized in clinical trials... -
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- Liver Abscess in Advanced Hepatocellular Carcinoma after Sorafenib Treatment
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Shin SK, Jung YK, Yoon HH, Kwon OS, Kim YS, Choi DJ, Kim JH
- KMID: 1711306
- Korean J Gastroenterol.
- 2014 Jan;63(1):47-50.
- doi: 10.4166/kjg.2014.63.1.47
Hepatocellular carcinoma (HCC) is a critical global health issue and the third most common cause of cancer-related deaths worldwide. The majority of patients who present HCC are already at an... -
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- High-Dose Vitamin C Promotes Regression of Multiple Pulmonary Metastases Originating from Hepatocellular Carcinoma
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Seo MS, Kim JK, Shim JY
- KMID: 2163643
- Yonsei Med J.
- 2015 Sep;56(5):1449-1452.
- doi: 10.3349/ymj.2015.56.5.1449
We report a case of regression of multiple pulmonary metastases, which originated from hepatocellular carcinoma after treatment with intravenous administration of high-dose vitamin C. A 74-year-old woman presented to the... -
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- Recent developments in systemic chemotherapy for hepatocellular carcinoma
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Han CJ
- KMID: 1073325
- Korean J Hepatol.
- 2008 Mar;14(1):4-11.
- doi: 10.3350/kjhep.2008.14.1.4
Despite recent developments in various chemotherapeutic agents and the performing of numerous clinical trials, chemotherapy still produces unsatisfactory results in hepatocellular carcinoma due to poor clinical benefit compared with untreated... -
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- Phase II Study to Topotecan and Cisplatin in Advanced Hepatocellular Carcinoma
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Lee GY, Kim BS, Seo YT, Choi SH, Kim HJ, Choi DS, Ko JY, Yang SH, Byun JH
- KMID: 1106144
- Korean J Intern Med.
- 2003 Jun;18(2):104-108.
BACKGROUND: Hepatocellular carcinoma remains a highly chemoresistant neoplasm and is a common malignancy with poor prognosis in Korea. We performed a phase II study to evaluate the efficacy and toxicities... -
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- Lamivudine versus Entecavir for Newly Diagnosed Hepatitis B Virus-Related Hepatocellular Carcinoma
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Kim JH, Sinn DH, Kim K, Kim H, Gwak GY, Paik YH, Choi MS, Lee JH, Koh KC, Paik SW
- KMID: 2412100
- Gut Liver.
- 2016 Nov;10(6):939-947.
- doi: 10.5009/gnl15527
BACKGROUND/AIMS: Antiviral therapy is a key component in the management of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) patients. However, whether the potent drug entecavir is more effective than a... -
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- Current Status of Molecular Targeted Therapies in Hepatocellular Carcinoma
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Suh SJ, Yim HJ
- KMID: 1501636
- Korean J Gastroenterol.
- 2013 Mar;61(3):136-146.
- doi: 10.4166/kjg.2013.61.3.136
Hepatocellular carcinoma (HCC) is one of the leading causes of cancer death in Korea. Curative treatment is only possible when the disease is diagnosed at the early stage. The prognosis... -
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- Novel EGFR-TK Inhibitor EKB-569 Inhibits Hepatocellular Carcinoma Cell Proliferation by AKT and MAPK Pathways
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Kim H, Lim HY
- KMID: 1786011
- J Korean Med Sci.
- 2011 Dec;26(12):1563-1568.
- doi: 10.3346/jkms.2011.26.12.1563
Epidermal growth factor receptor (EGFR)-targeted therapies have been effective in some cancers, but not in hepatocellular carcinoma (HCC). The aim of this study was to investigate the drug potential to... -
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- Long-term outcomes of patients with advanced hepatocellular carcinoma who achieved complete remission after sorafenib therapy
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Park JG
- KMID: 2351029
- Clin Mol Hepatol.
- 2015 Sep;21(3):287-294.
- doi: 10.3350/cmh.2015.21.3.287
BACKGROUND/AIMS: Sorafenib is currently the sole molecular targeted agent that improves overall survival in advanced hepatocellular carcinoma (HCC). Despite the efficacy of sorafenib, the response rate varies in patients with... -
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- A Case of Complete Regression of Hepatocellular Carcinoma during Administration of COX-2 Inhibitor
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Song HJ, Kim YS, Han CH, Jang JY, Kim JH, Cheon YK, Kim YS, Moon JH, Cho YD, Shim CS, Kwon KH, Kim BS
- KMID: 760678
- Korean J Hepatol.
- 2006 Sep;12(3):449-454.
Overexpression of cyclooxygenase-2 (COX-2) has been associated with hepatocarcinogenesis. Inhibitors of COX-2 have proapoptotic and antiproliferative effects on malignant tumors and inhibit tumor invasion to the surrounding tissues. We report... -
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- Efficacy of Hepatic Arterial Infusion Therapy for Advanced Hepatocellular Carcinoma Using 5-fluorouracil and Cisplatin
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Jang BK, Kwon KM, Chung WJ, Park KS, Cho KB, Hwang JS, Ahn SH, Kim GC, Kim YH, Choi JS, Kwon JH
- KMID: 760563
- Korean J Hepatol.
- 2004 Dec;10(4):271-278.
BACKGROUND/AIMS: There has been no standard treatment for advanced hepatocellular carcinoma (HCC) until now. The aim of this study was to evaluate the efficacy of hepatic arterial infusion therapy... -
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- Thalidomide for Treating Metastatic Hepatocellular Carcinoma: A Pilot Study
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Han SH, Park SH, Kim JH, Lee JJ, Kwon SY, Kwon OS, Kim SS, Kim JH, Kim KK, Park YH, Lee JN, Nam E, Bang SM, Cho EK, Shin DB, Lee JH
- KMID: 759855
- Korean J Intern Med.
- 2006 Dec;21(4):225-229.
- doi: 10.3904/kjim.2006.21.4.225
BACKGROUND: Thalidomide has been reported to have antitumor activity for treating metastatic hepatocellular carcinoma (HCC). We evaluated the safety and efficacy of using thalidomide for treating selected patients with... -
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- MRI Findings and Prediction of Time to Progression of Patients with Hepatocellular Carcinoma Treated with Drug-eluting Bead Transcatheter Arterial Chemoembolization
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Lee S, Kim KA, Park MS, Choi SY
- KMID: 2164484
- J Korean Med Sci.
- 2015 Jul;30(7):965-973.
- doi: 10.3346/jkms.2015.30.7.965
The purpose of this study was to investigate the utility of MRI findings after drug-eluting beads (DEB) - transcatheter arterial chemoembolization (TACE) for hepatocellular carcinoma in predicting time to progression... -
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- Efficacy and safety of hepatic arterial infusion chemotherapy for advanced hepatocellular carcinoma as first-line therapy
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Oh MJ, Lee HJ, Lee SH
- KMID: 1705207
- Clin Mol Hepatol.
- 2013 Sep;19(3):288-299.
- doi: 10.3350/cmh.2013.19.3.288
BACKGROUND/AIMS: Hepatic arterial infusion chemotherapy (HAIC) with 5-fluorouracil and cisplatin for intractable advanced hepatocellular carcinoma (HCC) may have survival benefits. We aimed to determine the efficacy and safety of HAIC... -
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- Transarterial Chemoembolization Using Gelatin Sponges or Microspheres Plus Lipiodol-Doxorubicin versus Doxorubicin-Loaded Beads for the Treatment of Hepatocellular Carcinoma
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Liu YS, Ou MC, Tsai YS, Lin XZ, Wang CK, Tsai HM, Chuang MT
- KMID: 2069990
- Korean J Radiol.
- 2015 Feb;16(1):125-132.
- doi: 10.3348/kjr.2015.16.1.125
OBJECTIVE: To retrospectively compare treatment of hepatocellular carcinoma (HCC) with transarterial chemoembolization (TACE) using gelatin sponges or microspheres plus lipiodol-doxorubicin vs. doxorubicin-loaded drug-eluting beads (DEB). MATERIALS AND METHODS: A total of... -
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- Combination treatment with intrahepatic arterial infusion and intratumoral injection chemotherapy in patients with far-advanced hepatocellular carcinoma and arterioportal or arteriovenous shunts: preliminary results
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Kim JS, Park YM, Kim NY, Yun HK, Lee KJ, Kim BH, Park SJ, Yeon JW, Jung G
- KMID: 1015571
- Korean J Hepatol.
- 2011 Jun;17(2):120-129.
- doi: 10.3350/kjhep.2011.17.2.120
BACKGROUND/AIMS: Combination treatment consisting of hepatic arterial infusion chemotherapy with epirubicin and cisplatin (HAIC-EC) and systemic infusion of low-dose 5-fluorouracil (5-FU) are sometimes effective against advanced hepatocellular carcinoma (HCC). However,... -
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- A Simplified Technique of Percutaneous Hepatic Artery Port-Catheter Insertion for the Treatment of Advanced Hepatocellular Carcinoma with Portal Vein Invasion
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Choi SY, Kim AH, Kim KA, Won JY, Lee DY, Lee KH
- KMID: 1119228
- Korean J Radiol.
- 2010 Dec;11(6):648-655.
- doi: 10.3348/kjr.2010.11.6.648
OBJECTIVE: We assessed the outcomes of a simplified technique for the percutaneous placement of a hepatic artery port-catheter system for chemotherapy infusion in advanced hepatocellular carcinoma with portal vein invasion.... -
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- Efficacy of Hepatic Arterial Infusion Therapy for Advanced Hepatocellular Carcinoma Using 5-Fluorouracil, Epirubicin and Mitomycin-C
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Hwang JY, Jang BK, Kwon KM, Chung WJ, Park KS, Cho KB, Hwang JS, Ahn SH, Kim GC, Kim YH, Choi JS, Kwon JH
- KMID: 2439746
- Korean J Gastroenterol.
- 2005 Feb;45(2):118-124.
BACKGROUND/AIMS: Prognosis of advanced hepatocellular carcinoma (HCC) treated by conventional therapies has been considered to be poor. The aim of this study was to evaluate the efficacy of hepatic... -
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- Clinical outcomes of systemic chemotherapy in hepatocellular carcinoma patients with multiple lung metastases
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Yoon KT, Choi JW, Park JY, Ahn SH, Paik YH, Lee KS, Han KH, Chon CY, Kim DY
- KMID: 1381466
- Korean J Hepatol.
- 2008 Sep;14(3):360-370.
- doi: 10.3350/kjhep.2008.14.3.360
BACKGROUND/AIMS: Advanced hepatocellular carcinoma (HCC) with multiple lung metastases has a poor prognosis with no effective treatment having been established. This study evaluated the outcomes of systemic chemotherapy for... -
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- Optimal technique and response of doxorubicin beads in hepatocellular cancer: bead size and dose
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Martin R, Irurzun J, Munchart J, Trofimov I, Scupchenko A, Tatum C, Narayanan
- KMID: 1105514
- Korean J Hepatol.
- 2011 Mar;17(1):51-60.
- doi: 10.3350/kjhep.2011.17.1.51
BACKGROUND/AIMS: It has been shown that the drug-eluting beads loaded with doxorubicin (DEBDOX) are effective for the treatment of hepatocellular carcinoma (HCC). However, the optimal safety and efficacy still remain... -
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