Korean J Hepatol.  2007 Mar;13(1):9-19.

Hypoxia in Hepatocellular Carcinoma

• Myung SJ
• Yoon JH

Abstract

Hepatocellular carcinoma (HCC) is characterized by hypervascularity, indicating that angiogenesis plays a vital role in HCC growth and progression. A number of anti-angiogenic therapies are being utilized in clinical trials in patients with HCC. However, the therapeutic efficacy of anti-angiogenic monotherapy is still insufficient. While inhibition of angiogenesis results in tumor hypoxia and cell death, this inhibition may also activate hypoxia-induced cell signals that may promote HCC progression. Therefore, an understanding of these signals may be essential in designing efficient anti-angiogenic therapies. This review summarizes the role of hypoxia-induced signals in HCC.

Keyword

Carcinoma, hepatocellular; Angiogenesis inducing agent; Angiogenesis inhibitors; Hypoxia

MeSH Terms

Angiogenesis Inhibitors/*therapeutic use
Carcinoma, Hepatocellular/*drug therapy
Cell Hypoxia
Disease Progression
Humans
Liver Neoplasms/*drug therapy