- The Role of Beta Blockers in Treating Hypertensive Patients
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Lim SY
- KMID: 2172264
- Chonnam Med J.
- 2009 Aug;45(2):75-78.
- doi: 10.4068/cmj.2009.45.2.75
Beta-blockers have been used to treat hypertension for many years. Although beta-blockers can lower blood pressure, current data concerning the efficacy of these drugs have been disappointing, and the value... -
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- Hypertensive Heart Failure Associated with Middle Aortic Syndrome Reversed Dramatically by Endovascular Management
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Kim W, Park CS, Kim HJ, Kim KH, An HM, Kim YH, Lim CH, Kang WY, Hwang SH, Kim W
- KMID: 1980369
- J Cardiovasc Ultrasound.
- 2011 Sep;19(3):144-147.
- doi: 10.4250/jcu.2011.19.3.144
A 42-year-old male patient presented with refractory hypertension and congestive heart failure. He had taken hydrochlorthiazide 50 mg, carvedilol 25 mg, diltiazem 180 mg, and losartan 100 mg per day.... -
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- Comparing the Effects of Carvedilol Enantiomers on Regression of Established Cardiac Hypertrophy Induced by Pressure Overload
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Hao J, Kim CH
- KMID: 1458943
- Lab Anim Res.
- 2010 Mar;26(1):75-82.
- doi: 10.5625/lar.2010.26.1.75
Pressure overload diseases such as valvular stenosis and systemic hypertension morphologically manifest in patients as cardiac concentric hypertrophy. Preventing cardiac remodeling due to increased pressure overload is important to reduce... -
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- Adrenocorticotropic Hormone-Independent Cushing Syndrome with Bilateral Cortisol-Secreting Adenomas
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Ku EJ, Hong AR, Kim YA, Bae JH, Chang MS, Kim SW
- KMID: 1973812
- Endocrinol Metab.
- 2013 Jun;28(2):133-137.
- doi: 10.3803/EnM.2013.28.2.133
A 48-year-old woman was incidentally found to have bilateral adrenal masses, 2.8 cm in diameter on the right, and 2.3 cm and 1.7 cm in diameter on the left, by... -
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- Matrix Metalloproteinase-2 Expression of the Injured Anterior Cruciate Ligament in the Knee and Changes in Relation to Signal Transduction Pathways
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Lee HS, Kwon JY, Woo YK
- KMID: 2199064
- J Korean Orthop Res Soc.
- 2008 Oct;11(2):64-71.
PURPOSE: This study was designed to pursue the basic relationship between MMP-2 and ligament injury via ex vivo stretching of the anterior cruciate ligament (ACL) and its changes by signal... -
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- Forskolin Enhances Synaptic Transmission in Rat Dorsal Striatum through NMDA Receptors and PKA in Different Phases
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Cho HS, Lee HH, Choi SJ, Kim KJ, Jeun SH, Li QZ, Sung KW
- KMID: 2285355
- Korean J Physiol Pharmacol.
- 2008 Dec;12(6):293-297.
- doi: 10.4196/kjpp.2008.12.6.293
The effect of forskolin on corticostriatal synaptic transmission was examined by recording excitatory postsynaptic currents (EPSCs) in rat brain slices using the whole-cell voltage-clamp technique. Forskolin produced a dose-dependent increase... -
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- The Effect of Enalapril and Carvedilol on Left Ventricular Dysfunction in Middle Childhood and Adolescent Patients With Muscular Dystrophy
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Kwon HW, Kwon BS, Kim GB, Chae JH, Park JD, Bae EJ, Noh CI
- KMID: 2225032
- Korean Circ J.
- 2012 Mar;42(3):184-191.
- doi: 10.4070/kcj.2012.42.3.184
BACKGROUND AND OBJECTIVES: In Duchenne and Becker muscular dystrophies, cardiac function deteriorates with time resulting in heart failure which is often fatal. We prospectively evaluated the effect of enalapril and... -
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- Activation of the cGMP/Protein Kinase G Pathway by Nitric Oxide Can Decrease TRPV1 Activity in Cultured Rat Dorsal Root Ganglion Neurons
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Jin Y, Kim J, Kwak J
- KMID: 1768016
- Korean J Physiol Pharmacol.
- 2012 Jun;16(3):211-217.
- doi: 10.4196/kjpp.2012.16.3.211
Recent studies have demonstrated that nitric oxide (NO) activates transient receptor potential vanilloid subtype 1 (TRPV1) via S-nitrosylation of the channel protein. NO also modulates various cellular functions via activation... -
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- A Case of Steroid-responsive C1q Nephropathy Presenting as Focal Segmental Glomerulosclerosis
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Yune YM, Choi SJ, Kim NR, Park MY, Kwon KW, Jin SY, Kim JK, Hwang SD
- KMID: 2307177
- Korean J Nephrol.
- 2009 Nov;28(6):648-652.
C1q nephropathy is an immune complex glomerulonephritis defined by the presence of mesangial immunoglobins and complement deposits, most notably C1q, and the absence of clinical and laboratory evidence of systemic... -
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- High K(+)-Induced Relaxation by Nitric Oxide in Human Gastric Fundus
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Kim DH, Kim YC, Choi W, Yun HY, Sung R, Kim HS, Kim H, Yoo RY, Park SM, Yun SJ, Song YJ, Xu WX, Lee SJ
- KMID: 1493961
- Korean J Physiol Pharmacol.
- 2012 Oct;16(5):297-303.
- doi: 10.4196/kjpp.2012.16.5.297
This study was designed to elucidate high K(+)-induced relaxation in the human gastric fundus. Circular smooth muscle from the human gastric fundus greater curvature showed stretch-dependent high K+ (50 mM)-induced... -
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- Frovatriptan is Effective and Well Tolerated in Korean Migraineurs: A Double-Blind, Randomized, Placebo-Controlled Trial
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Moon HS, Chu MK, Park JW, Oh K, Chung JM, Cho YJ, Kim EG, Do JK, Jung HG, Kwon SU
- KMID: 2135478
- J Clin Neurol.
- 2010 Mar;6(1):27-32.
- doi: 10.3988/jcn.2010.6.1.27
BACKGROUND AND PURPOSE: Frovatriptan is a selective 5-HT1B/1D agonist with a long duration of action and a low incidence of side effects. Although several placebo-controlled trials have documented the clinical... -
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- Effects of Histamine on Cultured Interstitial Cells of Cajal in Murine Small Intestine
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Kim BJ, Kwon YK, Kim E, So I
- KMID: 1429386
- Korean J Physiol Pharmacol.
- 2013 Apr;17(2):149-156.
- doi: 10.4196/kjpp.2013.17.2.149
Interstitial cells of Cajal (ICCs) are the pacemaker cells in the gastrointestinal tract, and histamine is known to regulate neuronal activity, control vascular tone, alter endothelial permeability, and modulate gastric... -
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- Telmisartan Versus Carvedilol in Hypertensive Patients with Metabolic Syndrome: Effects on Blood Pressure, Arterial Stiffness, Blood Glucose, and Lipid Metabolism
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Kim YS, Kim SY, Bae JH, Nah DY, Rhee MY, Lee MM, Huh HJ, Chae SL, Kim YK
- KMID: 1750379
- J Korean Soc Hypertens.
- 2010 Dec;16(4):44-53.
BACKGROUND: We compared the effects of telmisartan and carvedilol on blood pressure (BP), aortic stiffness, glucose, and lipid metabolism in hypertensive patients with metabolic syndrome (MS). METHODS: A total of 26... -
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- Cardioprotective signaling cascade of A2 adenosine receptor agonist 5'-N-ethylcarboxaminidoadenosine against myocardial reperfusion injury
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Lee YC, Jang YH, Kim CJ, Kim JM
- KMID: 1782548
- Korean J Anesthesiol.
- 2008 Dec;55(6):716-722.
- doi: 10.4097/kjae.2008.55.6.716
BACKGROUND: This experiments investigated the signaling cascade responsible for anti-infarct effect by an A2 adenosine receptor (AR) agonist 5'-N-Ethylcarboxaminidoadenosine (NECA). METHODS: Langendorff perfused isolated rat hearts were subjected to 30 minutes... -
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- Doxazosin Treatment Attenuates Carbon Tetrachloride-Induced Liver Fibrosis in Hamsters through a Decrease in Transforming Growth Factor beta Secretion
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Munoz-Ortega MH, Llamas-Ramirez RW, Romero-Delgadillo NI, Elias-Flores TG, de Jesus Tavares-Rodriguez E, del Rosario Campos-Esparza M, Cervantes-Garcia D, Munoz-Fernandez L, Gerardo-Rodriguez M, Ventura-Juarez J
- KMID: 2382350
- Gut Liver.
- 2016 Jan;10(1):101-108.
- doi: 10.5009/gnl14459
BACKGROUND/AIMS: The development of therapeutic strategies for the treatment of cirrhosis has become an important focus for basic and clinical researchers. Adrenergic receptor antagonists have been evaluated as antifibrotic drugs... -
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- Nitric Oxide-mediated Relaxation by High K+ in Human Gastric Longitudinal Smooth Muscle
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Kim YC, Choi W, Yun HY, Sung R, Yoo RY, Park SM, Yun SJ, Kim MJ, Song YJ, Xu WX, Lee SJ
- KMID: 2285428
- Korean J Physiol Pharmacol.
- 2011 Dec;15(6):405-413.
- doi: 10.4196/kjpp.2011.15.6.405
This study was designed to elucidate high-K+induced response of circular and longitudinal smooth muscle from human gastric corpus using isometric contraction. Contraction from circular and longitudinal muscle stripes of gastric... -
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- Phosphorylation of phospholipase D1 and the modulation of its interaction with RhoA by cAMP-dependent protein kinase
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Jang MJ, Lee MJ, Park HY, Bae YS, Min DS, Ryu SH, Kwak JY
- KMID: 1380212
- Exp Mol Med.
- 2004 Apr;36(2):172-178.
Agents that elevate cellular cAMP are known to inhibit the activation of phospholipase D (PLD). We investigated whether PLD can be phosphorylated by cAMP-dependent protein kinase (PKA) and PKA-mediated phosphorylation... -
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- Role of PKG-L-type calcium channels in the antinociceptive effect of intrathecal sildenafil
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Kim WM, Yoon MH, Cui JH
- KMID: 1110855
- J Vet Sci.
- 2010 Jun;11(2):103-106.
- doi: 10.4142/jvs.2010.11.2.103
Sildenafil increases the cyclic guanosine monophosphate (cGMP) by inhibition of a phosphodiesterase 5, thereby leading to an antinociceptive effect. The increased cGMP may exert the effect on an L-type calcium... -
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- Protein kinase A mediates microglial activation induced by plasminogen and gangliosides
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Min KJ, Yang MS, Jou I, Joe EH
- KMID: 1123767
- Exp Mol Med.
- 2004 Oct;36(5):461-467.
In the injured brain, microglia is known to be activated and produce proinflammatory mediators such as interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha) and inducible nitric oxide synthase (iNOS). We investigated... -
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- Protein kinase C modulates telomerase activity in human cervical cancer cells
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Kim YW, Hur SY, Kim TE, Lee JM, Namkoong S, Ki IK, Kim JW
- KMID: 938880
- Exp Mol Med.
- 2001 Sep;33(3):156-163.
Telomerase, a ribonucleoprotein reverse transcriptase that extends telomeres of eukaryotic chromosomes is repressed in normal somatic cells but is activated during development and neoplasia. The regulation mechanism of telomerase activity... -
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