- Effect of aspect ratio on the uptake and toxicity of hydroxylated-multi walled carbon nanotubes in the nematode, Caenorhabditis elegans
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Eom HJ, Jeong JS, Choi J
- KMID: 2380077
- Environ Health Toxicol.
- 2015 ;30(1):e2015001.
- doi: 10.5620/eht.e2015001
OBJECTIVES: In this study, the effect of tube length and outer diameter (OD) size of hydroxylated-multi walled carbon nanotubes (OH-MWCNTs) on their uptake and toxicity was investigated in the nematode... -
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- Mechanisms of aging-related proteinopathies in Caenorhabditis elegans
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Kim DK, Kim TH, Lee SJ
- KMID: 2361550
- Exp Mol Med.
- 2016 Oct;48(10):e263.
- doi: 10.1038/emm.2016.109
Aging is the most important risk factor for human neurodegenerative diseases such as Alzheimer's and Parkinson's diseases. Pathologically, these diseases are characterized by the deposition of specific protein aggregates in... -
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- Anti-oxidative Effect of Piperine from Piper nigrum L. in Caenorhabditis elegans
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Park HM, Kim JH, Kim DK
- KMID: 2459969
- Nat Prod Sci.
- 2019 Sep;25(3):255-260.
- doi: 10.20307/nps.2019.25.3.255
Piper nigrum L. (Piperaceae), which is a well-known food seasoning, has been used as a traditional medicine for the treatment of vomiting, abdominal pain, diarrhea and anorexia in Korea, China... -
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- Moringa oleifera Prolongs Lifespan via DAF-16/FOXO Transcriptional Factor in Caenorhabditis elegans
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Im JS, Lee HN, Oh JW, Yoon YJ, Park JS, Park JW, Kim JH, Kim YS, Cha DS, Jeon H
- KMID: 2355146
- Nat Prod Sci.
- 2016 Sep;22(3):201-208.
- doi: 10.20307/nps.2016.22.3.201
Here in this study, we investigated the lifespan-extending effect and underlying mechanism of methanolic extract of Moringa olelifa leaves (MML) using Caenorhabditis elegans (C. elegans) model system. To define the... -
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- Comparative study of oxidative stress caused by anthracene and alkyl-anthracenes in Caenorhabditis elegans
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Roh JY, Kim PG, Kwon JH
- KMID: 2434031
- Environ Health Toxicol.
- 2018 Mar;33(1):e2018006.
- doi: 10.5620/eht.e2018006
Oxidative stress was evaluated for anthracene (Ant) and alkyl-Ants (9-methylanthracene [9-MA] and 9,10-dimethylanthracene [9,10-DMA]) in Caenorhabditis elegans to compare changes in toxicity due to the degree of alkylation. Worms were... -
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- Acanthopanax sessiliflorus stem confers increased resistance to environmental stresses and lifespan extension in Caenorhabditis elegans
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Park JK, Kim CK, Gong SK, Yu AR, Lee MY, Park SK
- KMID: 2313774
- Nutr Res Pract.
- 2014 Oct;8(5):526-532.
- doi: 10.4162/nrp.2014.8.5.526
BACKGROUND/OBJECTIVES: Acanthopanax sessiliflorus is a native Korean plant and used as traditional medicine or an ingredient in many Korean foods. The free radical theory of aging suggests that cellular oxidative... -
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- Identification of Caenorhabditis elegans MicroRNA Targets Using a Kernel Method
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Lee WJ, Nam JW, Kim SK, Zhang BT
- KMID: 1572614
- Genomics Inform.
- 2005 Mar;3(1):15-23.
BACKGROUND: MicroRNAs (miRNAs)are a class of noncoding RNAs found in various organisms such as plants and mammals. However, most of the mRNAs regulated by miRNAs are unknown. Furthermore, miRNA targets... -
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- High glucose diets shorten lifespan of Caenorhabditis elegans via ectopic apoptosis induction
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Choi SS
- KMID: 2313520
- Nutr Res Pract.
- 2011 Jun;5(3):214-218.
Diets based on carbohydrates increase rapidly the blood glucose level due to the fast conversion of carbohydrates to glucose. High glucose diets have been known to induce many lifestyle diseases.... -
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- Involvement of Caenohabditis elegans MAPK Signaling Pathways in Oxidative Stress Response Induced by Silver Nanoparticles Exposure
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Roh JY, Eom HJ, Choi J
- KMID: 2052547
- Toxicol Res.
- 2012 Mar;28(1):19-24.
In the present study, toxicity of silver nanoparticles (AgNPs) was investigated in the nematode, Caenohabditis elegans focusing on the upstream signaling pathway responsible for regulating oxidative stress, such as mitogen-activated... -
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- The Longevity Properties of 1,2,3,4,6-Penta-O-Galloyl-beta-D-Glucose from Curcuma longa in Caenorhabditis elegans
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Ahn D, Cha DS, Lee EB, Kim BJ, Lee SY, Jeon H, Ahn MS, Lim HW, Lee HY, Kim DK
- KMID: 2170661
- Biomol Ther.
- 2013 Nov;21(6):442-446.
Here in this study, we isolated 1,2,3,4,6-penta-O-galloyl-beta-D-glucose (PGG) from Curcuma longa L. and elucidated the lifespanextending effect of PGG using Caenorhabditis elegans model system. In the present study, PGG demonstrated... -
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- Genistein from Vigna angularis Extends Lifespan in Caenorhabditis elegans
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Lee EB, Ahn D, Kim BJ, Lee SY, Seo HW, Cha YS, Jeon H, Eun JS, Cha DS, Kim DK
- KMID: 2380366
- Biomol Ther.
- 2015 Jan;23(1):77-83.
- doi: 10.4062/biomolther.2014.075
The seed of Vigna angularis has long been cultivated as a food or a folk medicine in East Asia. Genistein (4',5,7-trihydroxyisoflavone), a dietary phytoestrogen present in this plant, has been... -
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- Longevity and Stress Resistant Property of 6-Gingerol from Zingiber officinale Roscoe in Caenorhabditis elegans
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Lee EB, Kim JH, An CW, Kim YJ, Noh YJ, Kim SJ, Kim JE, Shrestha A, Ham HN, Leem JY, Jo HK, Kim DS, Moon KH, Lee JH, Jeong KO, Kim DK
- KMID: 2427510
- Biomol Ther.
- 2018 Nov;26(6):568-575.
- doi: 10.4062/biomolther.2017.215
In order to discover lifespan-extending compounds made from natural resources, activity-guided fractionation of Zingiber officinale Roscoe (Zingiberaceae) ethanol extract was performed using the Caenorhabditis elegans (C. elegans) model system. The... -
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- Lindera obtusiloba Extends Lifespan of Caenorhabditis elegans
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Kim HN, Seo HW, Kim BS, Lim HJ, Lee HN, Park JS, Yoon YJ, Oh JW, Oh MJ, Kwon J, Oh CH, Cha DS, Jeon H
- KMID: 2312884
- Nat Prod Sci.
- 2015 Jun;21(2):128-133.
- doi: 10.0000/nps.2015.21.2.128
Lindera obtusiloba has been widely used as a traditional medicine for the treatment of lots of diseases, including abdominal pain, bruise, and hepatocirrhosis. Here in this study, we elucidated the... -
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- Cloning of the novel putative apoptosis-related gene of Spirometra erinacei (Order Pseudophyllidae)
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Lee SU, Huh S
- KMID: 1720522
- Korean J Parasitol.
- 2006 Sep;44(3):233-237.
- doi: 10.3347/kjp.2006.44.3.233
We postulated that apolysis was processed in accordance with apoptotic changes occurring in a cestode, Spirometra erinacei (Pseudophyllidea). We cloned the novel putative apoptosis-associated gene from S. erinacei via screening... -
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- Lifespan Extending and Stress Resistant Properties of Vitexin from Vigna angularis in Caenorhabditis elegans
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Lee EB, Kim JH, Cha YS, Kim M, Song SB, Cha DS, Jeon H, Eun JS, Han S, Kim DK
- KMID: 2380310
- Biomol Ther.
- 2015 Nov;23(6):582-589.
- doi: 10.4062/biomolther.2015.128
Several theories emphasize that aging is closely related to oxidative stress and disease. The formation of excess ROS can lead to DNA damage and the acceleration of aging. Vigna angularis... -
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- Caenorhabditis elegans: A Model System for Anti-Cancer Drug Discovery and Therapeutic Target Identification
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Kobet RA, Pan X, Zhang B, Pak SC, Asch AS, Lee MH
- KMID: 2380313
- Biomol Ther.
- 2014 Sep;22(5):371-383.
- doi: 10.4062/biomolther.2014.084
The nematode Caenorhabditis elegans (C. elegans) offers a unique opportunity for biological and basic medical researches due to its genetic tractability and well-defined developmental lineage. It also provides an exceptional... -
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- Screening of toxic potential of graphene family nanomaterials using in vitro and alternative in vivo toxicity testing systems
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Chatterjee N, Yang JS, Park K, Oh SM, Park J, Choi J
- KMID: 2380083
- Environ Health Toxicol.
- 2015 ;30(1):e2015007.
- doi: 10.5620/eht.e2015007
OBJECTIVES: The widely promising applications of graphene nanomaterials raise considerable concerns regarding their environmental and human health risk assessment. The aim of the current study was to evaluate the toxicity... -
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- Alpha-Ketoglutarate: Physiological Functions and Applications
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Wu N, Yang M, Gaur U, Xu H, Yao Y, Li D
- KMID: 2170534
- Biomol Ther.
- 2016 Jan;24(1):1-8.
- doi: 10.4062/biomolther.2015.078
Alpha-ketoglutarate (AKG) is a key molecule in the Krebs cycle determining the overall rate of the citric acid cycle of the organism. It is a nitrogen scavenger and a source... -
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- Maintaining the Constant Exposure Condition for an Acute Caenorhabditis elegans Mortality Test Using Passive Dosing
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Kwon HC, Roh JY, Lim D, Choi J, Kwon JH
- KMID: 2380165
- Environ Health Toxicol.
- 2011 ;26(1):e2011015.
OBJECTIVES: Maintaining the constant exposure to hydrophobic organic compouds in acute toxicity tests is one of the most difficult issues in the evaluation of their toxicity and corresponding risks. Passive... -
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- Short-term Treatment of Daumone Improves Hepatic Inflammation in Aged Mice
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Park JH, Ha H
- KMID: 1791429
- Korean J Physiol Pharmacol.
- 2015 May;19(3):269-274.
- doi: 10.4196/kjpp.2015.19.3.269
Chronic inflammation has been proposed as one of the main molecular mechanisms of aging and age-related diseases. Although evidence in humans is limited, short-term calorie restriction (CR) has been shown... -
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