- In vivo ligation of glucocorticoid-induced TNF receptor enhances the T-cell immunity to herpes simplex virus type 1
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La S, Kim E, Kwon B
- KMID: 1056231
- Exp Mol Med.
- 2005 Jun;37(3):193-198.
GITR (glucocorticoid-induced TNF receptor) is a recently identified member of the TNF receptor superfamily. The receptor is preferentially expressed on CD4+CD25+ regulatory T cells and GITR signals break the suppressive... -
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- Antitumor immunity induced by tumor cells engineered to express a membrane-bound form of IL-2
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Chang MR, Lee WH, Choi JW, Park SO, Paik SG, Kim YS
- KMID: 1056237
- Exp Mol Med.
- 2005 Jun;37(3):240-249.
Transduction of cytokine gene into tumor cells is a promising method of tumor therapy, but the value is limited by accompanying side effects. To focus antitumor immune response to tumor... -
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- Relation between lymphocyte subpopulations of peripheral blood and immune responses of modified live hog cholera virus vaccine in pigs treated with an ionized alkali mineral complex
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Park BK, Park YH, Seo KS
- KMID: 1103474
- J Vet Sci.
- 2000 Jun;1(1):49-52.
Thirty-nine healthy pigs (28-32 days old) were purchased from a commercial swine farm and housed at swine pens of the College. The animals were vaccinated intramuscularly (1 ml) with an... -
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- Identificaiton of Novel Immunogenic Human Papillomavirus Type 16 E7-Specific Epitopes Restricted to HLA-A*33;03 for Cervical Cancer Immunotherapy
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Kim S, Chung HW, Kong HY, Lim JB
- KMID: 2374187
- Yonsei Med J.
- 2017 Jan;58(1):43-50.
- doi: 10.3349/ymj.2017.58.1.43
PURPOSE: To identify new immunogenic HLA-A*33;03-restricted epitopes from the human papillomavirus (HPV) 16 E7 protein for immunotherapy against cervical cancer. MATERIALS AND METHODS: We synthesized fourteen overlapping 15-amino acid peptides and... -
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- Direct Analysis of HBV-Specific CD8+ Lymphocyte By Tetrameric HLA-A2/core 18-27 Complex in Chronic Hepatitis B
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Lee CK, Suh JH, Cho YS, Han KH, Chung JB, Chon CY, Moon YM
- KMID: 1123163
- Korean J Hepatol.
- 2002 Jun;8(2):139-148.
BACKGROUNDS/AIMS: Hepatitis B virus(HBV) specific cytotoxic T lymphocyte (CTL) response is believed to play a major role in virus control and liver damage in chronic hepatitis B(CHB). We performed this... -
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- Experimental Murine Fascioliasis Derives Early Immune Suppression with Increased Levels of TGF-beta and IL-4
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Chung JY, Bae YA, Yun DH, Yang HJ, Kong Y
- KMID: 1792122
- Korean J Parasitol.
- 2012 Dec;50(4):301-308.
In fascioliasis, T-helper 2 (Th2) responses predominate, while little is known regarding early immune phenomenon. We herein analyzed early immunophenotype changes of BALB/c, C57BL/6, and C3H/He mice experimentally infected with... -
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- Chemokine Receptor Expression of Hepatitis B Virus-Specific CD8+ Lymphocyte in Chronic B Viral Infection
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Lee CK, Suh JH, Cho YS, Han KH, Chung JB, Chon CY, Moon YM
- KMID: 863111
- Korean J Hepatol.
- 2002 Dec;8(4):363-370.
BACKGROUND/AIMS: The protective role of HBV-specific CD8+ cells is dependent on their ability to efficiently migrate to the infected liver, where they may exert an effector function. The migratory... -
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- Suppression of CD4+ T-Cells in the Spleen of Mice Infected with Toxoplasma gondii KI-1 Tachyzoites
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Kim WH, Shin EH, Kim JL, Yu SY, Jung BK, Chai JY
- KMID: 1104700
- Korean J Parasitol.
- 2010 Dec;48(4):325-329.
- doi: 10.3347/kjp.2010.48.4.325
Toxoplasma gondii KI-1, a recent new isolate from Korea, shows similar pathogenicity and infectivity to mice compared to the virulent RH strain. To understand characteristics of host immunity, including immune... -
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- Activated natural killer cell-mediated immunity is required for the inhibition of tumor metastasis by dendritic cell vaccination
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Kim A, Noh YW, Kim KD, Jang YS, Choe YK, Lim JS
- KMID: 1123764
- Exp Mol Med.
- 2004 Oct;36(5):428-443.
Immunization with dendritic cells (DCs) pulsed with tumor antigen can activate tumor-specific cytotoxic T lymphocytes (CTL), which is responsible for tumor protection and regression. In this study, we examined whether... -
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- Tumor-Specific Immunity Induced by Cryoablation in a Murine Renal Cell Carcinoma Model
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Kim HK, Pyun JH, Cho S, Kang SG, Lee JG, Kim JJ, Cheon J, Park HS, Kang SH
- KMID: 2070099
- Korean J Urol.
- 2014 Dec;55(12):834-840.
- doi: 10.4111/kju.2014.55.12.834
PURPOSE: To evaluate tumor-specific immunity and define the mechanisms involved in the cryoimmunologic response, we compared the tumor control efficacy and immunologic responses of cryoablation with those of surgical excision... -
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- A Novel Recombinant BCG Vaccine Encoding Eimeria tenella Rhomboid and Chicken IL-2 Induces Protective Immunity Against Coccidiosis
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Wang Q, Chen L, Li J, Zheng J, Cai N, Gong P, Li S, Li H, Zhang X
- KMID: 1792178
- Korean J Parasitol.
- 2014 Jun;52(3):251-256.
A novel recombinant Bacille Calmette-Guerin (rBCG) vaccine co-expressed Eimeria tenella rhomboid and cytokine chicken IL-2 (chIL-2) was constructed, and its efficacy against E. tenella challenge was observed. The rhomboid gene... -
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- Inhibition of Lewis Lung Carcinoma Growth by Toxoplasma gondii through Induction of Th1 Immune Responses and Inhibition of Angiogenesis
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Kim JO, Jung SS, Kim SY, Kim TY, Shin DW, Lee JH, Lee YH
- KMID: 1785787
- J Korean Med Sci.
- 2007 Sep;22(Suppl):S38-S46.
- doi: 10.3346/jkms.2007.22.S.S38
Toxoplasma gondii is an obligate intracellular protozoan parasite that induces antitumor activity against certain types of cancers. However, little information is available regarding the immunologic mechanisms that regulate these effects.... -
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- Comparative Quantitative Analysis of Cluster of Differentiation 45 Antigen Expression on Lymphocyte Subsets
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Im M, Chae H, Kim T, Park HH, Lim J, Oh EJ, Kim Y, Park YJ, Han K
- KMID: 1735845
- Korean J Lab Med.
- 2011 Jul;31(3):148-153.
- doi: 10.3343/kjlm.2011.31.3.148
BACKGROUND: Since the recent introduction of radioimmunotherapy (RIT) using antibodies against cluster of differentiation (CD) 45 for the treatment of lymphoma, the clinical significance of the CD45 antigen has been... -
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- Programmed death-1 pathway blockade produces a synergistic antitumor effect: combined application in ovarian cancer
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Zhu X, Lang J
- KMID: 2413224
- J Gynecol Oncol.
- 2017 Sep;28(5):e64.
- doi: 10.3802/jgo.2017.28.e64
Programmed death-1 (PD-1) and its ligand are part of the immune checkpoint pathway that down-regulates effector T cells in immune response, thereby causing immune suppression. The PD-1/programmed death-ligand 1 (PD-L1)... -
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