- Cytogenetic Studies of Peripheral Leukocytes following Surgery and Radiotherapy in Patients with Breast Carcinoma
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Hahn S
- KMID: 687741
- Yonsei Med J.
- 1977 Dec;18(2):136-139.
- doi: 10.3349/ymj.1977.18.2.136
Chromosome analysis were carried out on peripheral blood leukocytes of breast cancer patient during the irradiation therapy after unilateral simple mastectomy. The observations were made at intervals varying from one... -
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- Detecting p53 gene mutation of breast cancer and defining differences between silver staining PCR-SSCP and immunohistochemical staining
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Ryu JW, Lee MC, Jang WC
- KMID: 1731238
- J Korean Med Sci.
- 2000 Feb;15(1):73-77.
- doi: 10.3346/jkms.2000.15.1.73
This study detects and defines the patterns of p53 gene mutations in breast cancers. We analyse p53 gene mutations through comparing the results of single-strand-conformation-polymorphism (SSCP) and immunohistochemistry (IHC), and... -
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- The detection of circulating breast cancer cells in peripheral blood by reverse transcriptase-polymerase chain reaction
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Bae JW, Choi KH, Kim HG, Park SH
- KMID: 648123
- J Korean Med Sci.
- 2000 Apr;15(2):194-198.
- doi: 10.3346/jkms.2000.15.2.194
Some circulating cancer cells in the blood play a central role in the metastatic process and may have a major influence on patient progress. Their numbers can be very small... -
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- Loss of heterozygosity on chromosome XP22.2-p22.13 and Xq26.1-q27.1 in human breast carcinomas
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Choi C, Kim MH, Juhng SW
- KMID: 1745556
- J Korean Med Sci.
- 1998 Jun;13(3):311-316.
- doi: 10.3346/jkms.1998.13.3.311
In an attempt to investigate the X chromosome harboring putative tumor suppressor genes (TSGs) in sporadic breast carcinoma, we performed loss of heterozygosity (LOH) studies on 23 breast carcinomas... -
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- Bfl-1 Gene Expression in Breast Cancer: Its Relationship with other Prognostic Factors
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Yoon HS, Hong SH, Kang HJ, Ko BK, Ahn SH, Huh JR
- KMID: 2157626
- J Korean Med Sci.
- 2003 Apr;18(2):225-230.
- doi: 10.3346/jkms.2003.18.2.225
The Bfl-1 gene, which was isolated from human fetal liver and only recently described, is a member of the Bcl-2 gene family. Reverse transcriptase-polymerase chain reaction was performed on RNA... -
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- Clinicopathological Significance of Maspin Expression in Breast Cancer
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Lee MJ, Suh CH, Li ZH
- KMID: 1781841
- J Korean Med Sci.
- 2006 Apr;21(2):309-314.
- doi: 10.3346/jkms.2006.21.2.309
Maspin is a unique serine proteinase inhibitor that has tumor suppressor activity. It has been reported that maspin is expressed in normal human mammary epithelial cells and it is down-regulated... -
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- Expression of MT-1 MMP, MMP2, MMP9 and TIMP2 mRNAs in Ductal Carcinoma in Situ and Invasive Ductal Carcinoma of the Breast
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Kim HJ, Park CI, Park BW, Lee HD, Jung WH
- KMID: 1715851
- Yonsei Med J.
- 2006 Jun;47(3):333-342.
- doi: 10.3349/ymj.2006.47.3.333
We investigated the expression of membrane type-1 (MT1)-MMP, MMP2, MMP9 and TIMP2 mRNAs and their roles in ductal carcinoma in situ (DCIS) and T1 and T2 invasive ductal carcinoma of... -
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- Comparison of Her-2, EGFR and Cyclin D1 in Primary Breast Cancer and Paired Metastatic Lymph Nodes: An Immunohistochemical and Chromogenic In Situ Hybridization Study
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Cho EY, Han JJ, Choi YL, Kim KM, Oh YL
- KMID: 1107533
- J Korean Med Sci.
- 2008 Dec;23(6):1053-1061.
- doi: 10.3346/jkms.2008.23.6.1053
The significant advance in the development of molecular-targeting drugs has made an evaluation of Her-2, EGFR, and cyclin D1 an important clinical issue in breast cancer patients. This study compared... -
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- Availability of Fine Needle Aspirates for the Assessment of HER2 Gene Amplification in Invasive Breast Cancer Patients
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Lee JW, Noh WC, Kim MS, Kim HA, Chang YH, Hong YJ, Hong SI, Lee JK
- KMID: 1781572
- Korean J Lab Med.
- 2008 Oct;28(5):392-399.
- doi: 10.3343/kjlm.2008.28.5.392
BACKGROUND: FISH and immunohistochemistry (IHC) on formalin-fixed paraffin embedded (FFPE) tissue are currently used in the clinical laboratory to determine HER2 status in invasive breast cancer patients. Since tissue-based methods... -
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- LYR71, a derivative of trimeric resveratrol, inhibits tumorigenesis by blocking STAT3-mediated matrix metalloproteinase 9 expression
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Kim JE, Kim HS, Shin YJ, Lee CS, Won C, Lee SA, Lee JW, Kim Y, Kang JS, Ye SK, Chung MH
- KMID: 1104805
- Exp Mol Med.
- 2008 Oct;40(5):514-522.
- doi: 10.3858/emm.2008.40.5.514
Tumor migration/invasion is the main cause of tumor progression and STAT3 is needed to enhance tumor migration/invasion by up-regulating MMP-9. Thus, agents that inhibit STAT3 activation may be used as... -
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- beta-TrCP1 degradation is a novel action mechanism of PI3K/mTOR inhibitors in triple-negative breast cancer cells
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Yi YW, Kang HJ, Bae EJ, Oh S, Seong YS, Bae I
- KMID: 2155408
- Exp Mol Med.
- 2015 Feb;47(2):e143.
- doi: 10.1038/emm.2014.127
An F-box protein, beta-TrCP recognizes substrate proteins and destabilizes them through ubiquitin-dependent proteolysis. It regulates the stability of diverse proteins and functions as either a tumor suppressor or an oncogene.... -
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