Yonsei Med J.  1977 Dec;18(2):136-139. 10.3349/ymj.1977.18.2.136.

Cytogenetic Studies of Peripheral Leukocytes following Surgery and Radiotherapy in Patients with Breast Carcinoma

• Hahn S

• KMID: 687741
• DOI: http://doi.org/10.3349/ymj.1977.18.2.136

Abstract

Chromosome analysis were carried out on peripheral blood leukocytes of breast cancer patient during the irradiation therapy after unilateral simple mastectomy. The observations were made at intervals varying from one to 5 weeks during the therapy and one month after the completion of tile treatment. During the first and second weeks of treatment normal metaphase was noted and during the 4th and 5th weeks, there were no mitotic figures from the cell population. The chromosomal aberrations found after 3 weeks of treatment were, 11% of simple chromatid breaks, 7% of chromatid interchanges (translocations) and 8% of fragments. One month after the completion of the course of treatment showed a return of mitosis and that total chromatid breaks had decreased to 5%. Radiation effects on cell division and chromosome aberration are discussed.

MeSH Terms

Breast Neoplasms/genetics*
Breast Neoplasms/radiotherapy
Breast Neoplasms/surgery
Carcinoma, Intraductal, Noninfiltrating/genetics*
Carcinoma, Intraductal, Noninfiltrating/radiotherapy
Carcinoma, Intraductal, Noninfiltrating/surgery
Case Report
Chromosome Aberrations*
Female
Human
Leukocytes/ultrastructure*
Middle Age