J Korean Breast Cancer Soc.  2004 Jun;7(2):65-71. 10.4048/jkbcs.2004.7.2.65.

Partial Breast Irradiation (PBI)

Affiliations
  • 1Department of Radiation Oncology, Yonsei University College of Medicine, Yonsei Cancer Center, Seoul, Korea. cosuh317@yumc.yonsei.ac.kr

Abstract

Breast conservation treatment (BCT) is a combination of breast conservation surgery (BCS) and radiotherapy (RT). Conventional radiotherapy after BCS requires 5~6 weeks of RT to whole breast followed by 1~2 weeks of RT to tumor bed. This lengthy tretment modality is one of the difficulties in performing BCT. Recently, irradiation to the tumor bed only (partial breast irradiation, PBI) in selected patients was examined as a way to shorten the period of RT because a local recurrence after a BCT occurs mainly around the primary tumor bed. PBI with a large fractional dose might shorten the treatment time to one week. There are various methods of PBI including interstitial brachytherapy, balloon brachytherapy, external beam radiotherapy such as three-dimensional conformal radiotherapy, intensity modulated radiotherapy and proton therapy, and intraoperative radiotherapy. The results of the phase I/II studies using these new techniques have reported a similar local control rate and cosmetic results compared with the historical data using whole breast irradiation (WBRT). However, a long-term follow-up of the phase III randomized trials will be needed in order to determine the equivalence of PBI alone to WBRT in the treatment of selected patients with early breast cancer.


MeSH Terms

Brachytherapy
Breast Neoplasms
Breast*
Follow-Up Studies
Humans
Proton Therapy
Radiotherapy
Radiotherapy, Conformal
Recurrence

Cited by  1 articles

Validation of Radiation Volume by Analysis of Recurrence Pattern in Breast-conserving Treatment for Early Breast Cancer
Su Jung Shim, Yong Bae Kim, Ki Chang Keum, Ik Jae Lee, Hy De Lee, Chang-Ok Suh
J Breast Cancer. 2009;12(4):257-264.    doi: 10.4048/jbc.2009.12.4.257.

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