J Breast Cancer.  2017 Dec;20(4):333-339. 10.4048/jbc.2017.20.4.333.

Interactions of Family History of Breast Cancer with Radiotherapy in Relation to the Risk of Breast Cancer Recurrence

• Li D
• Mai V
• Gerke T
• Pinney SM
• Yaghjyan L

• KMID: 2398202
• DOI: http://doi.org/10.4048/jbc.2017.20.4.333

Abstract

PURPOSE
We examined associations between a family history of breast cancer and the risk of breast cancer recurrence in women who received or did not receive radiotherapy.
METHODS
Our study included 2,440 women enrolled in the Breast Cancer Registry of Greater Cincinnati. Information on breast cancer risk factors, including detailed family history of breast cancer, characteristics of the primary tumor, treatment received, and recurrence status was collected at baseline and via updates. Associations between a family history of breast cancer and the risk of breast cancer recurrence were examined separately in women treated with and without radiotherapy using survival analysis.
RESULTS
Over an average follow-up time of 8.78 years, we found no associations between a family history of breast cancer and the risk of breast cancer recurrence among women with a history of radiotherapy (hazard ratio [HR], 0.96; 95% confidence interval [CI], 0.75-1.23). Among women who did not receive radiotherapy, the total number of relatives with breast cancer was positively associated with the risk of breast cancer recurrence (HR, 1.21; 95% CI, 1.00-1.47). We found no interactions of radiotherapy with family history (p-interaction >0.05).
CONCLUSION
Radiotherapy for a primary breast cancer in women with a family history of breast cancer does not increase risk of breast cancer recurrence. If these findings are replicated in future studies, the results may translate into an important health message for breast cancer survivors with a family history of breast cancer.

Keyword

Breast neoplasms; Radiotherapy; Recurrence

MeSH Terms

Breast Neoplasms*
Breast*
Female
Follow-Up Studies
Humans
Radiotherapy*
Recurrence*
Risk Factors
Survivors

Figure

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  Figure 1 Participant selection diagram.

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