- The Effect of Anoxia on the Amino Acid and Carbohydrate Metabolism of the Isolated Dog Brain
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Huh K, Gilboe DD, Minsker DH
- KMID: 1106108
- Yonsei Med J.
- 1967 Dec;8(1):13-17.
- doi: 10.3349/ymj.1967.8.1.13
The isolated dog brain was perfused for a period of 4 minutes with blood normal in all constituents, but pathologically low in oxygen in order to follow the metabolic response... -
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- Effect of hypothermia on brain cell membrane function and energy metabolism after transient global hypoxia-ischemia in the newborn piglet
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Park WS, Chang YS, Lee MH
- KMID: 1129907
- J Korean Med Sci.
- 2001 Jun;16(3):335-341.
- doi: 10.3346/jkms.2001.16.3.335
This study was done to determine the effects of hypothermia on brain cell membrane function and energy metabolism after transient hypoxia-ischemia (HI) in the newborn piglet. Cerebral HI was induced... -
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- Metabolism-Centric Overview of the Pathogenesis of Alzheimer's Disease
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Kang S, Lee YH, Lee JE
- KMID: 2419103
- Yonsei Med J.
- 2017 May;58(3):479-488.
- doi: 10.3349/ymj.2017.58.3.479
Alzheimer's disease (AD) is a degenerative brain disease and the most common cause of dementia. AD is characterized by the extracellular amyloid beta (Aβ) plaques and intraneuronal deposits of neurofibrillary... -
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- Downregulation of neurotrophic factors in the brain of a mouse model of Gaucher disease: implications for neuronal loss in Gaucher disease
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Kim EY, Hong YB, Go SH, Lee B, Jung SC
- KMID: 1110118
- Exp Mol Med.
- 2006 Aug;38(4):348-356.
Gaucher disease is a glycosphingolipid storage disease caused by deficiency of glucocerebrosidase, resulting in the accumulation of glucosylceramide in lysosomes. The neuronopathic forms of this disease are associated with neuronal... -
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- Brain site-specific proteome changes in aging-related dementia
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Manavalan , Mishra M, Feng L, Sze SK, Akatsu H, Heese K
- KMID: 2154258
- Exp Mol Med.
- 2013 Sep;45(9):e39.
This study is aimed at gaining insights into the brain site-specific proteomic senescence signature while comparing physiologically aged brains with aging-related dementia brains (for example, Alzheimer's disease (AD)). Our study... -
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- An Autoradiographic Study on Metabolism of Serotonin in Cerebral Nerve Cells Using 5-Hydroxytryptophan-C
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Choi KD, Ahn SB, Oh YK, Rhim KS, Moon BY
- KMID: 1106107
- Yonsei Med J.
- 1967 Dec;8(1):8-12.
- doi: 10.3349/ymj.1967.8.1.8
In order to demonstrate autoradiographically the sites of serotonin metabolism in the brain, DL 5-HTP and DL 5-HTP-C14 were intraperitoneally administered to healthy adult mice. In order to distinguish histochemically... -
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- Effect of Harderian adenectomy on the statistical analyses of mouse brain imaging using positron emission tomography
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Kim M, Woo SK, Yu JW, Lee YJ, Kim KM, Kang JH, Eom K, Nahm SS
- KMID: 1737622
- J Vet Sci.
- 2014 Mar;15(1):157-161.
- doi: 10.4142/jvs.2014.15.1.157
Positron emission tomography (PET) using 2-deoxy-2-[18F] fluoro-D-glucose (FDG) as a radioactive tracer is a useful technique for in vivo brain imaging. However, the anatomical and physiological features of the Harderian... -
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- Expression of the plant viral protease NIa in the brain of a mouse model of Alzheimer's disease mitigates Abeta pathology and improves cognitive function
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Kim TK, Han HE, Kim H, Lee JE, Choi D, Park WJ, Han PL
- KMID: 1402318
- Exp Mol Med.
- 2012 Dec;44(12):740-748.
The plant viral protease, NIa, has a strict substrate specificity for the consensus sequence of Val-Xaa-His-Gln, with a scissoring property after Gln. We recently reported that NIa efficiently cleaved the... -
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- Metabolic Alterations in Parkinson's Disease after Thalamotomy, as Revealed by 1H MR Spectroscopy
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Baik HM, Choe BY, Lee HK, Suh TS, Son BC, Lee JM
- KMID: 754060
- Korean J Radiol.
- 2002 Sep;3(3):180-188.
- doi: 10.3348/kjr.2002.3.3.180
OBJECTIVE: To determine, using proton magnetic resonance spectroscopy (1H MRS) whether thalamotomy in patients with Parkinson's disease gives rise to significant changes in regional brain metabolism. MATERIALS AND METHODS: Fifteen patients... -
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- Concurrent Low Brain and High Liver Uptake on FDG PET Are Associated with Cardiovascular Risk Factors
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Nam HY, Jun S, Pak K, Kim IJ
- KMID: 2427952
- Korean J Radiol.
- 2017 Apr;18(2):392-401.
- doi: 10.3348/kjr.2017.18.2.392
OBJECTIVE: Concurrent low brain and high liver uptake are sometimes observed on fluorine-18-labeled fluoro-2-deoxy-D-glucose (FDG) positron emission tomography (PET). We investigated the potential clinical significance of this uptake pattern related... -
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- Synapsin-1 and tau reciprocal O-GlcNAcylation and phosphorylation sites in mouse brain synaptosomes
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Kang MJ, Kim C, Jeong H, Cho BK, Ryou AL, Hwang D, Mook-Jung , Yi EC
- KMID: 2154248
- Exp Mol Med.
- 2013 Jun;45(6):e29.
O-linked N-acetylglucosamine (O-GlcNAc) represents a key regulatory post-translational modification (PTM) that is reversible and often reciprocal with phosphorylation of serine and threonine at the same or nearby residues. Although recent... -
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- Quantitative in Vivo Detection of Brain Cell Death after Hypoxia Ischemia Using the Lipid Peak at 1.3 ppm of Proton Magnetic Resonance Spectroscopy in Neonatal Rats
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Ahn SY, Yoo HS, Lee JH, Sung DK, Jung YJ, Sung SI, Lim KH, Chang YS, Lee JH, Kim KS, Park WS
- KMID: 1777505
- J Korean Med Sci.
- 2013 Jul;28(7):1071-1076.
- doi: 10.3346/jkms.2013.28.7.1071
This study was performed to determine the accuracy of proton magnetic spectroscopy (1H-MRS) lipid peak as a noninvasive tool for quantitative in vivo detection of brain cell death. Seven day-old... -
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- Simultaneous deletion of floxed genes mediated by CaMKIIalpha-Cre in the brain and in male germ cells: application to conditional and conventional disruption of Goalpha
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Choi CI, Yoon SP, Choi JM, Kim SS, Lee YD, Birnbaumer L, Suh-Kim H
- KMID: 2155358
- Exp Mol Med.
- 2014 May;46(5):e93.
- doi: 10.1038/emm.2014.14
The Cre/LoxP system is a well-established approach to spatially and temporally control genetic inactivation. The calcium/calmodulin-dependent protein kinase II alpha subunit (CaMKIIalpha) promoter limits expression to specific regions of the... -
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- Proteomic Analysis of Rat Brains Following Exposure to Electroconvulsive Therapy
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Lee CS, Kang KR, Lee JY, Park CS, Hahn KH, Sohn JW, Kim BJ
- KMID: 1794419
- J Korean Med Sci.
- 2009 Feb;24(1):132-137.
- doi: 10.3346/jkms.2009.24.1.132
Electroconvulsive therapy (ECT) is one of the most effective treatments used in psychiatry to date. The mechanisms of ECT action, however, are the least understood and still unclear. As a... -
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- Cerebral Oxygenation during Laparoscopic Surgery: Jugular Bulb versus Regional Cerebral Oxygen Saturation
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Choi SH, Kim SH, Lee SJ, Soh SR, Oh YJ
- KMID: 1776943
- Yonsei Med J.
- 2013 Jan;54(1):225-230.
- doi: 10.3349/ymj.2013.54.1.225
PURPOSE: We hypothesized that regional cerebral oxygen saturation (rSO2) could replace jugular bulb oxygen saturation (SjvO2) in the steep Trendelenburg position under pneumoperitoneum. Therefore, we evaluated the relationship between SjvO2... -
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- Gender-Specific Associations between CHGB Genetic Variants and Schizophrenia in a Korean Population
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Shin JG, Kim JH, Park CS, Kim BJ, Kim JW, Choi IG, Hwang J, Shin HD, Woo SI
- KMID: 2419121
- Yonsei Med J.
- 2017 May;58(3):619-625.
- doi: 10.3349/ymj.2017.58.3.619
PURPOSE: Schizophrenia is a devastating mental disorder and is known to be affected by genetic factors. The chromogranin B (CHGB), a member of the chromogranin gene family, has been proposed... -
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