- Production of Recombinant Anti-Cancer Vaccines in Plants
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Lee JH, Ko K
- KMID: 2386899
- Biomol Ther.
- 2017 Jul;25(4):345-353.
- doi: 10.4062/biomolther.2016.126
Plant expression systems have been developed to produce anti-cancer vaccines. Plants have several advantages as bioreactors for the production of subunit vaccines: they are considered safe, and may be used... -
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- Bioreactor systems are essentially required for stem cell bioprocessing
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Cha JM, Lee MY, Hong J
- KMID: 2469524
- Precis Future Med.
- 2019 Mar;3(1):19-23.
- doi: 10.23838/pfm.2018.00128
As stem cell technologies have rapidly advanced, the stem cell therapy market has been forecast to reach hundreds of millions of USD in market value within the next 5 years.... -
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- Histological Method to Study the Effect of Shear Stress on Cell Proliferation and Tissue Morphology in a Bioreactor
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Chabanon M, Duval H, Grenier J, Beauchesne C, Goyeau B, David B
- KMID: 2449234
- Tissue Eng Regen Med.
- 2019 Jun;16(3):225-235.
- doi: 10.1007/s13770-019-00181-3
BACKGROUND: Tissue engineering represents a promising approach for the production of bone substitutes. The use of perfusion bioreactors for the culture of bone-forming cells on a three-dimensional porous scaffold resolves... -
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- Recent Advances for Enhancing Drug Metabolizing Functions of Hepatocyte-like Cells Derived from Human Pluripotent Stem Cells
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Han J, Kim JH
- KMID: 2129472
- Hanyang Med Rev.
- 2015 Nov;35(4):196-206.
- doi: 10.7599/hmr.2015.35.4.196
Hepatocyte-like cells (HLCs) derived from human pluripotent stem cells are a promising cell source for drug screening and toxicity tests. Thus, various hepatic differentiating protocols have been developed, leading to... -
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- Artificial Liver Devices and Bioartificial Liver Systems: Current Status
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Kwon CH, Lee SK, Park JK, Lee DH, Lee JH
- KMID: 2202344
- J Korean Soc Transplant.
- 2011 Mar;25(1):15-21.
- doi: 10.4285/jkstn.2011.25.1.15
Acute liver failure is a rapidly progressive disease of the liver associated with high morbidity and mortality without liver transplantation. Although good survival after transplantation can be achieved, due to... -
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- Effects of combined mechanical stimulation on the proliferation and differentiation of pre-osteoblasts
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Kang KS, Lee SJ, Lee H, Moon W, Cho DW
- KMID: 1107378
- Exp Mol Med.
- 2011 Jun;43(6):367-373.
- doi: 10.3858/emm.2011.43.6.040
We observed how combined mechanical stimuli affect the proliferation and differentiation of pre-osteoblasts. For this research, a bioreactor system was developed that can simultaneously stimulate cells with cyclic strain and... -
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- Glucosamine Hydrochloride and N-Acetylglucosamine Influence the Response of Bovine Chondrocytes to TGF-β3 and IGF in Monolayer and Three-Dimensional Tissue Culture
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Pizzolatti ALA, Gaudig F, Seitz D, Roesler CR, Salmoria G
- KMID: 2441269
- Tissue Eng Regen Med.
- 2018 Dec;15(6):781-791.
- doi: 10.1007/s13770-018-0150-x
BACKGROUND: Glucosamine hydrochloride (GlcN·HCl) has been shown to inhibit cell growth and matrix synthesis, but not with N-acetyl-glucosamine (GlcNAc) supplementation. This effect might be related to an inhibition of critical... -
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- Submerged Culture of Phellinus linteus for Mass Production of Polysaccharides
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Lee JW, Baek SJ, Kim YS
- KMID: 1487340
- Mycobiology.
- 2008 Sep;36(3):178-182.
- doi: 10.4489/MYCO.2008.36.3.178
In order to increase the mycelial production of Phellinus linteus, which exhibits potent anticancer activity, some ingredients of the medium used to culture P. linteus were investigated. The optimal medium... -
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- Digestion Pattern of Antihypertensive Angiotensin I-Converting Enzyme Inhibitory Peptides from Saccharomyces cerevisiae in a Successive Simulated Gastricintestinal Bioreactor
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Jang JH, Jeong SC, Lee JK, Lee JS
- KMID: 2312617
- Mycobiology.
- 2011 Mar;39(1):67-69.
A cell-free extract of Saccharomyces cerevisiae containing the angiotensin I-converting enzyme (ACE) inhibitory peptide was treated in a successive simulated gastric-intestinal bioreactor (step 1: amylase digestion, step 2: gastric fluid... -
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- Estimation of Cell Concentration by Light Transmitter During the Culture of Methylotrophic Yeast Pichia pastoris
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Choi DB, Park EY, Lee YB, Na YH, Lim CK
- KMID: 2312418
- Mycobiology.
- 2003 Dec;31(4):226-228.
The multiple correlation coefficient between the values determined by dry weight and those determined by fluorometer was observed with r = 0.96 and the standard error of calibration was 0.034.... -
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- An overview of cartilage tissue engineering
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Kim HW, Han CD
- KMID: 1114564
- Yonsei Med J.
- 2000 Dec;41(6):766-773.
- doi: 10.3349/ymj.2000.41.6.766
Articular cartilage regeneration refers to the formation of new tissue that is indistinguishable from the native articular cartilage with respect to zonal organization, biochemical composition, and mechanical properties. Due to... -
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- Automation of Solid-state Bioreactor for Oyster Mushroom Composting
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Lee HY, Kim WR, Min BH
- KMID: 2312388
- Mycobiology.
- 2002 Dec;30(4):228-232.
This study focused on the production of high quality compost for the growth of aero-thermophilic fungi, which has a promoting effect on the growth rate and production of oyster mushrooms.... -
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- Tissue engineering of urinary organs
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Park KD, Kwon IK, Kim YH
- KMID: 1114566
- Yonsei Med J.
- 2000 Dec;41(6):780-788.
- doi: 10.3349/ymj.2000.41.6.780
Tissue engineering can serve as an alternative treatment for a malfunctioning or lost organ. Isolated and expanded cells adhere to a temporary scaffold, proliferate, and secrete their own extracellular... -
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- Prefabrication of Axially Vascularized Bone by Combining β-Tricalciumphosphate, Arteriovenous Loop, and Cell Sheet Technique
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Ma D, Ren L, Cao Z, Li J, Cao J, Tian W, Yao H
- KMID: 2360807
- Tissue Eng Regen Med.
- 2016 Oct;13(5):579-584.
- doi: 10.1007/s13770-016-9095-0
The repair of bone defects poses a great challenge for reconstructive surgeons. Although the development of tissue engineering has exhibited promise in replacing damaged bone, the fabrication of large constructs... -
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- Current Progress in Tendon and Ligament Tissue Engineering
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Lim WL, Liau LL, Ng MH, Chowdhury , Law JX
- KMID: 2467049
- Tissue Eng Regen Med.
- 2019 Dec;16(6):549-571.
- doi: 10.1007/s13770-019-00196-w
BACKGROUND: Tendon and ligament injuries accounted for 30% of all musculoskeletal consultations with 4 million new incidences worldwide each year and thus imposed a significant burden to the society and... -
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- Artificial liver composed of liver slice culture system
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Park SS, Han JJ
- KMID: 1530116
- Korean J Anat.
- 1998 Jun;31(3):483-491.
Acute hepatic failure is one of the most fatal in clinical medicine, as it can be associated with a mortality rate of 80~ 90%. For the treatment of acute hepatic... -
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- Research Progress and Future Perspectives in Animal Stem Cell Research
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Han JY
- KMID: 2347582
- J Korean Med Assoc.
- 2002 Jun;45(6):719-727.
- doi: 10.5124/jkma.2002.45.6.719
Researches on manipulating pluripotent stem cells derived from blastocysts or primordial germ cells (PGCs) have a great advantage for developing innovative technologies in various fields of life science including medicine,... -
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- Effects of Mechanical Stimulation and Scaffolds for Nucleus Pulposus Replacement of Intervertebral Disc
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Ha SH, Kim DH, Shin JW, Gwak HC, Choi JS
- KMID: 2199044
- J Korean Orthop Res Soc.
- 2009 Dec;12(2):45-52.
PURPOSE: In this study, we investigated the potential of injectable hydrogel scaffolds for the regeneration of nucleus pulposus. MATERIALS AND METHODS: We prepared injectable hydrogels [Chitosan-Pluronic (CP), CP/Osteogenic Protein-1 (CP/OP-1), CP/Gly-Arg-Gly-Asp-Ser... -
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- Central Nervous System and the Colonic Bioreactor: Analysis of Colonic Microbiota in Patients with Stroke Unravels Unknown Mechanisms of the Host Defense after Brain Injury
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Swidsinski A, Loening-Baucke V, Kruger M, Kirsch S
- KMID: 2174249
- Intest Res.
- 2012 Oct;10(4):332-342.
- doi: 10.5217/ir.2012.10.4.332
BACKGROUND/AIMS: Stroke is accompanied by septic complications due to quickly changing polymicrobials of unclear origin. This study was aimed to find the source of stroke-associated-infections. METHODS: We investigated the biostructure of... -
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- Development of Bioreactor for Subjecting Cell to Versatile Physical Forces
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Hong JY, Park CS, Kim DH, Park SR, Min BH
- KMID: 2042112
- J Korean Orthop Res Soc.
- 2004 Apr;7(1):60-69.
PURPOSE: Articular cartilage is under continuous mechanical stresses during daily activity. The mechanical force must also be applied during the culturing process to produce a phenotypically correct tissue. We have... -
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