- White Matter Damage and Hippocampal Neurodegeneration Induced by Permanent Bilateral Occlusion of Common Carotid Artery in the Rat: Comparison between Wistar and Sprague-Dawley Strain
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Kim SK, Cho KO, Kim SY
- KMID: 2285348
- Korean J Physiol Pharmacol.
- 2008 Jun;12(3):89-94.
- doi: 10.4196/kjpp.2008.12.3.89
In order to reproduce chronic cerebral hypoperfusion as it occurs in human aging and Alzheimer's disease, we introduced permanent, bilateral occlusion of the common carotid arteries (BCCAO) in rats (Farkas... -
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- Purkinje cells loss in off spring due to maternal morphine sulfate exposure: a morphometric study
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Golalipour MJ, Ghafari S
- KMID: 2005875
- Anat Cell Biol.
- 2012 Jun;45(2):121-127.
- doi: 10.5115/acb.2012.45.2.121
The toxic effects of morphine sulfate in the adult cerebral cortex and one-day neonatal cerebellum have been studied. This study was carried out to evaluate the effect of maternal morphine... -
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- Effects of high-fat diet on the numerical density and number of neuronal cells and the volume of the mouse hypothalamus: a stereological study
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Namavar MR, Raminfard , Jahromi ZV, Azari H
- KMID: 2046745
- Anat Cell Biol.
- 2012 Sep;45(3):178-184.
- doi: 10.5115/acb.2012.45.3.178
It has been demonstrated that the type of diet affects the brain structure and function. Consumption of fat-rich food is one of the most important factors that lead to increase... -
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- Influence of Aspirin on Pilocarpine-Induced Epilepsy in Mice
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Jeong KH, Kim JY, Choi YS, Lee MY, Kim SY
- KMID: 1432758
- Korean J Physiol Pharmacol.
- 2013 Feb;17(1):15-21.
- doi: 10.4196/kjpp.2013.17.1.15
Aspirin (acetylsalicylic acid) is one of the most widely used therapeutic agents based on its pharmacological actions, including anti-inflammatory, analgesic, anti-pyretic, and anti-thrombotic effects. In this study, we investigated the... -
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- Neuroprotective Effect of Visnagin on Kainic Acid-induced Neuronal Cell Death in the Mice Hippocampus
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Kwon MS, Lee JK, Park SH, Sim YB, Jung JS, Won MH, Kim SM, Suh HW
- KMID: 2071691
- Korean J Physiol Pharmacol.
- 2010 Oct;14(5):257-263.
- doi: 10.4196/kjpp.2010.14.5.257
Visnagin (4-methoxy-7-methyl-5H-furo[3,2-g][1]-benzopyran-5-one), which is an active principle extracted from the fruits of Ammi visnaga, has been used as a treatment for low blood-pressure and blocked blood vessel contraction by inhibition... -
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- Effect of Regular Exercise Program on Cognitive Function in Chronic Cerebral Hypoperfused Rat
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Yun HS, Kim JK, Song MK, Seon HJ, Han JY, Choi IS, Lee SG
- KMID: 2048462
- Brain Neurorehabil.
- 2011 Sep;4(2):95-102.
- doi: 10.12786/bn.2011.4.2.95
OBJECTIVE: To investigate the effect of regular exercise program on cognitive function in chronic cerebral hypoperfused rat. METHOD: Forty-eight male Sprague-Dawley rats were used. Chronic cerebral hypoperfusion was induced by bilateral... -
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- Immunohistochemical Study of Glucose Transporters 1 and 3 in the Mouse Hippocampus after Kainic Acid Treatment
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Kwag SJ, Kim KH, Kim HJ, Kang SS, Cho GJ, Choi WS, Roh GS
- KMID: 2092944
- Korean J Anat.
- 2008 Sep;41(3):213-221.
Seizure activity increases glucose utilization within the brain in response to neuronal injury. In this study, we investigated the expression of two brain glucose transporter (GLUT) proteins, GLUT1 and GLUT3,... -
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- Functional activity of the cannabinoid 1 receptor is not affected by opioid antagonists in the rat brain
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Lee H
- KMID: 1767337
- Korean J Anesthesiol.
- 2013 Mar;64(3):257-261.
- doi: 10.4097/kjae.2013.64.3.257
BACKGROUND: WIN55212-2 is a synthetic cannabinoid agonist and selective to cannabinoid 1 (CB1) receptors, which are distributed mainly in the central nervous system. Opioid receptors and CB1 receptors have several... -
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- Inhibitory Effect of SPA0355, a Thiourea Analogue, on Inflammation and Alveolar Bone Loss in Rats with Ligature-Induced Periodontitis
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Bak EJ, Kim JH, Lee DE, Park BH, Ryu JH, Cha JH, Jeon R, Yoo YJ
- KMID: 2170775
- Int J Oral Biol.
- 2012 Jun;37(2):63-68.
It has been documented that SPA0355 exerts anti-inflammatory effects via the inhibition of nuclear factor-kappaB activation. In present study, we investigated the inhibitory effects of SPA0355 on periodontitis in an... -
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- Altered Expression of eNOS and VEGF in the Rat Choroid Plexus following Systemic Hyponatremia
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Kim JM, Jung YW
- KMID: 2092938
- Korean J Anat.
- 2008 Sep;41(3):155-162.
In the present study, alterations of the endothelial nitric oxide synthase (eNOS) and the vascular endothelial growth factor (VEGF) expression in the third ventricle choroid plexus and their effects to... -
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- Neuroprotection of Alpinia katsumadai Seed Extract against Neuronal Damage in the Ischemic Gerbil Hippocampus is Linked to Altered Brain-Derived Neurotrophic Factor
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Li H, Park JH, Yan B, Yoo KY, Lee CH, Choi JH, Hwang IK, Won MH
- KMID: 2391862
- Lab Anim Res.
- 2011 Mar;27(1):67-71.
- doi: 10.5625/lar.2011.27.1.67
The extract of Alpinia katsumadai, a member of the family Zingiberaceae, shows anti-inflammatory effects and antioxidant activity. We observed the neuroprotective effects of the extract from Alpinia katsumadai seed (EAKS)... -
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- The efficacy of SPA0355 in protecting beta cells in isolated pancreatic islets and in a murine experimental model of type 1 diabetes
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Bae UJ, Song MY, Jang HY, Gim HJ, Ryu JH, Lee SM, Jeon R, Park BH
- KMID: 2154270
- Exp Mol Med.
- 2013 Nov;45(11):e51.
Cytokines activate several inflammatory signals that mediate beta-cell destruction. We recently determined that SPA0355 is a strong anti-inflammatory compound, thus reporting its efficacy in protecting beta cells from various insults.... -
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- Arginine vasopressin (AVP) expressional changes in the hypothalamic paraventricular and supraoptic nuclei of stroke-prone spontaneously hypertensive rats
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Yi SS, Kim HJ, Do SG, Lee YB, Ahn HJ, Hwang IK, Yoon YS
- KMID: 2005874
- Anat Cell Biol.
- 2012 Jun;45(2):114-120.
- doi: 10.5115/acb.2012.45.2.114
Arginine vasopressin (AVP) is a neuropeptide with vasoconstrictive, antidiuretic, cardiovascular regulative and hepatic glycogenolysis effects, that also affects other behaviors including modulating learning. A number of studies on AVP regulation... -
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- Comparative Study of the L5 Spinal Nerve Transection Model and Sciatic Nerve Axotomy Model as a Peripheral Nerve Injury Model in Rat
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Song DY, Lee JH, Yu HN, Park CR, Woo RS, Hong SY, Cheon YH, Goo HN, Baik TK
- KMID: 2283707
- Korean J Phys Anthropol.
- 2012 Mar;25(1):11-21.
The aim of this study was to propose new more reliable peripheral nerve transection model to overcome the defect of the traditional sciatic axotomy model by specifically transecting L5 spinal... -
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- SPA0355 attenuates ischemia/reperfusion-induced liver injury in mice
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Bae UJ, Yang JD, Ka SO, Koo JH, Woo SJ, Lee YR, Yu HC, Cho BH, Zhao HY, Ryu JH, Lee SM, Jeon R, Park BH
- KMID: 2155374
- Exp Mol Med.
- 2014 Aug;46(8):e109.
- doi: 10.1038/emm.2014.48
Hepatic ischemia/reperfusion (I/R) injury leads to oxidative stress and acute inflammatory responses that cause liver damage and have a considerable impact on the postoperative outcome. Much research has been performed... -
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