- The Future of B-cell Activating Factor Antagonists in the Treatment of Systemic Lupus Erythematosus
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Stohl W
- KMID: 2378084
- J Rheum Dis.
- 2017 Apr;24(2):65-73.
- doi: 10.4078/jrd.2017.24.2.65
To review B-cell activating factor (BAFF)-antagonist therapy in systemic lupus erythematosus (SLE), literature was searched using the search words and phrases, “BAFFâ€, “B lymphocyte stimulator (BLyS)â€, “a proliferation-inducing ligand (APRIL)â€,... -
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- B-cell-activating factor is a regulator of adipokines and a possible mediator between adipocytes and macrophages
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Kim MY, Kim DH, Do MS
- KMID: 2154223
- Exp Mol Med.
- 2013 Jan;45(1):e4.
3T3-L1 adipocytes express the B-cell-activating factor (BAFF) and three different BAFF receptors (BAFF-Rs). Furthermore, BAFF expression is regulated by inflammatory modulators, such as tumor necrosis factor-alpha and rosiglitazone. Here we... -
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- Elevated Serum Levels of Visfatin in Patients with Henoch-Schonlein Purpura
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Cao N, Chen T, Guo ZP, Li MM, Jiao XY
- KMID: 2368149
- Ann Dermatol.
- 2014 Jun;26(3):303-307.
BACKGROUND: Henoch-Schonlein purpura (HSP) is an immune complex-mediated disease predominantly characterized by the deposition of circulating immune complexes containing immunoglobulin A (IgA) on the walls of small vessels. Although the... -
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- Immunoglobulin G4-Related Disease
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Moon SJ, Min JK
- KMID: 2222851
- J Rheum Dis.
- 2015 Aug;22(4):213-222.
- doi: 10.4078/jrd.2015.22.4.213
Immunoglobulin G4-related disease (IgG4-RD) is an emerging immune-mediated fibro-inflammatory disorder which can involve any organ. The main characteristics of IgG4-RD are increased serum IgG4 concentration, abundant IgG4+ plasma cells in... -
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- TACI:Fc scavenging B cell activating factor (BAFF) alleviates ovalbumin-induced bronchial asthma in mice
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Moon EY, Ryu SK
- KMID: 1047085
- Exp Mol Med.
- 2007 Jun;39(3):343-352.
Asthma was induced by the sensitization and challenge with ovalbumin (OVA) in mice. B-cell activating factor (BAFF) plays a role in mature B cell generation and maintenance. Here, we investigated... -
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- Regulation of B cell activating factor (BAFF) receptor expression by NF-kappaB signaling in rheumatoid arthritis B cells
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Woo YJ, Yoon BY, Jhun JY, Oh HJ, Min S, Cho ML, Park SH, Kim HY, Min JK
- KMID: 1107376
- Exp Mol Med.
- 2011 Jun;43(6):350-357.
- doi: 10.3858/emm.2011.43.6.038
B cells play an important role in the pathogenesis of rheumatoid arthritis (RA). High levels of B cell activating factor (BAFF) are detected in autoimmune diseases. BAFF and BAFF receptor... -
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- Recent Advances in the Concept and Pathogenesis of IgG4-Related Disease in the Hepato-Bilio-Pancreatic System
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Okazaki K, Yanagawa M, Mitsuyama , Uchida K
- KMID: 2070055
- Gut Liver.
- 2014 Sep;8(5):462-470.
- doi: 10.5009/gnl14107
Recent studies have proposed nomenclatures of type 1 autoimmune pancreatitis (AIP) (IgG4-related pancreatitis), IgG4-related sclerosing cholangitis (IgG4-SC), IgG4-related cholecystitis, and IgG4-related hepatopathy as IgG4-related disease (IgG4-RD) in the hepato-bilio-pancreatic system.... -
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- Molecular targeted therapies for microscopic polyangiitis and granulomatosis with polyangiitis
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Harigai M, Tsutsumino M, Takada H, Nagasaka K
- KMID: 2448340
- Korean J Intern Med.
- 2019 May;34(3):492-503.
- doi: 10.3904/kjim.2018.366
Clinical trials and observational studies have established cyclophosphamide (CY) or rituximab plus glucocorticoid (GC) as standard remission induction therapies in patients with microscopic polyangiitis (MPA) and granulomatosis with polyangiitis (GPA).... -
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- BAFF knockout improves systemic inflammation via regulating adipose tissue distribution in high-fat diet-induced obesity
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Kim DH, Do MS
- KMID: 2155394
- Exp Mol Med.
- 2015 Jan;47(1):e129.
- doi: 10.1038/emm.2014.98
Obesity is recognized as a chronic low-grade inflammatory state due to adipose tissue expansion being accompanied by an increase in the production of proinflammatory adipokines. Our group is the first... -
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- Role of Interleukin-10-Expressing B Cells on the Pathophysiology of Chronic Sinusitis
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Park HS, Park SK, Yeon SH, Xu J, Rha KS, Kim YM
- KMID: 2436518
- Korean J Otorhinolaryngol-Head Neck Surg.
- 2018 Aug;61(8):412-420.
- doi: 10.3342/kjorl-hns.2017.01067
BACKGROUND AND OBJECTIVES: Many kinds of inflammatory cells and cytokines are suggested to be related with pathophysiology of chronic rhinosinusitis with nasal polyp (CRSwNP), but its mechanism is not yet... -
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- B cell activation factor (BAFF) is a novel adipokine that links obesity and inflammation
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Kim YH, Choi BH, Cheon HG, Do MS
- KMID: 1123468
- Exp Mol Med.
- 2009 Mar;41(3):208-216.
- doi: 10.3858/emm.2009.41.3.024
B cell activation factor (BAFF) is a novel member of the TNF ligand superfamily, mainly produced by myeloid cells. BAFF has been shown to participate in B-cell survival and B-... -
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- Effect of Hydroxychloroquine Treatment on Dry Eyes in Subjects with Primary Sjögren's Syndrome: a Double-Blind Randomized Control Study
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Yoon CH, Lee HJ, Lee EY, Lee EB, Lee WW, Kim MK, Wee WR
- KMID: 2373734
- J Korean Med Sci.
- 2016 Jul;31(7):1127-1135.
- doi: 10.3346/jkms.2016.31.7.1127
The effect of hydroxychloroquine (HCQ) on dry eye has not been fully determined. This study aimed to compare the 12-week efficacy of HCQ medication with that of a placebo in... -
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- Immunological Characteristics in Refractory Chronic Rhinosinusitis with Nasal Polyps Undergoing Revision Surgeries
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Ryu G, Kim DK, Dhong HJ, Eun KM, Lee KE, Kong IG, Kim H, Chung SK, Kim DY, Rhee CS, Cho SH, Hong SD, Kim DW
- KMID: 2452757
- Allergy Asthma Immunol Res.
- 2019 Sep;11(5):664-676.
- doi: 10.4168/aair.2019.11.5.664
PURPOSE: Despite medical and surgical treatments, some cases of nasal polyps (NP) exhibit recidivism. However, the endotype of refractory chronic rhinosinusitis with NP (CRSwNP) remains unclear. Therefore, the objective of... -
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