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Is There Any Relationship Between Human Leucocyte Antigen Class II and Chronic Urticaria? (Chronic Urticaria and HLA Class II)

Oztas P, Onder M, Gonen S, Oztas MO, Soylemezoglu O

Human Leukocyte Antigen (HLA) typing of large groups of patients with various autoimmune diseases has demonstrated that some HLA alleles occur at higher frequencies in specific diseases than in the...
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HFE gene mutation, C282Y causing hereditary hemochromatosis in Caucasian is extremely rare in Korean population

Lee JY, Yoo KH, Hahn SH

Hereditary hemochromatosis (HFE), which affects 1 in 400 and has an estimated carrier frequency of 1 in 10 individuals in Western population, results in multiple organ damage caused by iron...
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Molecular genetics (HLA) of Behcet's disease

Mizuki N, Inoko H, Ohno S

Behcet's disease (BD) has been known to be strongly associated with the human leukocyte antigen (HLA) B51. This B51 association has been confirmed in many different ethnic groups between the...
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Increased Prevalence of Autoimmune Thyroid Disease in Patients with Type 1 Diabetes

Park YS, Kim TW, Kim WB, Cho BY

  • KMID: 759519
  • Korean J Intern Med.
  • 2000 Dec;15(3):202-210.
BACKGROUND: Type 1 diabetes mellitus is frequently associated with other autoimmune diseases. The occurrence of common features of autoimmune diseases and the coassociation of multiple autoimmune diseases in the same...
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Epstein-Barr virus latent genes

Kang MS, Kieff E

Latent Epstein-Barr virus (EBV) infection has a substantial role in causing many human disorders. The persistence of these viral genomes in all malignant cells, yet with the expression of limited...
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Genetic factors associated with development of cerebral malaria and fibrotic schistosomiasis

Hirayama K

Collaborative studies have identified some genetic factors contributing to the development of severe forms of malaria and schistosomiasis. In Thailand, the TNF-alpha 5'-flanking region shows biallelic polymorphic sites at nucleotides...
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Alterations of HLA class I and class II antigen expressions in borderline, invasive and metastatic ovarian cancers

Lee YS, Kim TE, Kim BK, Park YG, Kim GM, Jee SB, Ryu KS, Kim IK, Kim JW

  • KMID: 1093593
  • Exp Mol Med.
  • 2002 Mar;34(1):18-26.
In an effort to understand whether HLA class I and II plays any role in the process of tumorigenesis and metastasis, we have immunohistochemically examined expression of HLA class I...
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Isolation and Characterization of Chorionic Mesenchymal Stromal Cells from Human Full Term Placenta

Koo BK, Park IY, Kim J, Kim JH, Kwon A, Kim M, Kim Y, Shin JC, Kim JH

This study focused on the characterization of mesenchymal stromal cells (MSCs) from the chorion of human full term placenta from 15 donors. Chorionic MSCs revealed homologous fibroblast-like morphology and expressed...
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Development of a Web-based Program for the Identification of Human Leukocyte Antigen Antibody Specificities

Cha CH, Oh HB, Kim MH, Chae JM, Jung SY

BACKGROUND: Panel reactive antibody (PRA) test is used to determine whether a patient awaiting transplantation is previously sensitized. Tail analysis algorithm is widely used to identify antibody specificities, but...
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Expression of Mucin Genes in the Human Testis and Its Relationship to Spermatogenesis

Seo JT, Lee JS, Jun JH, Yang MH

In this study we investigate the expression pattern of mucin genes in the human testis and evaluate the relationship between the expression of mucin genes and impaired spermatogenesis in the...
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Characterization of lymphocyte subpopulations and major histocompatibility complex haplotypes of mastitis-resistant and susceptible cows

Park YH, Joo YS, Park JY, Moon JS, Kim SH, Kwon NH, Ahn JS, Davis WC, Davies CJ

  • KMID: 1094685
  • J Vet Sci.
  • 2004 Mar;5(1):29-39.
Bovine mastitis is an infectious disease with a major economic influence on the dairy industry worldwide. Many factors such as environment, pathogen, and host affect susceptibility or resistance of an...
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Screening and Molecular Cloning of a Protective Antigen from the Midgut of Haemaphysalis longicornis

Hu Y, Zhang J, Yang S, Wang H, Zeng H, Zhang T, Liu J

Vaccination is considered a promising alternative for controlling tick infestations. Haemaphysalis longicornis midgut proteins separated by SDS-PAGE and transferred to polyvinylidene difluoride (PVDF) membrane were screened for protective value against...
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Influence of the sequence variations of the HLA-DR promoters derived from human melanoma cell lines on nuclear protein binding and promoter activity

Lee TJ, Kim SJ, Park JH

In previous studies we reported that the expression of HLA-DR on melanoma cell lines was differentially modulated by IFN- gamma and that the transcription rate was responsible for this differential...
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Analysis of the precore and core promoter DNA sequence in liver tissues from tients with hepatocellular carcinoma

Cho SW, Shin YJ, Hahm KB, Jin JH, Kim YS, Kim JH, Kim HJ

To investigate the role of mutant hepatitis B virus (HBV) in the development of hepatocellular carcinoma (HCC), 20 patients with HCC were studied for precore and core promoter mutations in...
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Epstein-Barr Virus and p16INK4A Methylation in Squamous Cell Carcinoma and Precancerous Lesions of the Cervix Uteri

Kim NR, Lin Z, Kim KR, Cho HY, Kim I

Methylation of p16 is an important mechanism in cervical carcinogenesis. However, the relationship between cervical squamous cell carcinoma (SCC) and Epstein-Barr virus (EBV) remains controversial. Here, we explored whether EBV...
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HLA-linked Genetic Markers in Koreans

Kim JD, Choi IH, Kim SJ

The polymorphic variants of HLA-linked genetic markers GLO, Bf, C2 and C4 were determined in Koreans. The GLO2 allele was found at a similar frequency as compared with other orientals...
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Therapy of severe aplastic anemia with anti-human thymocyte globulin (ATGAM) with and without HLA-haploidentical bone-marrow infusion

Kim KY

Six patients with severe aplastic anemia treated with horse anti-human thymocyte globulin (ATG) and androgen. Four of these patients were only given ATG (ATGAMR), 16 mg/Kg/dose x 10 doses. The...
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Differentiation of Human Dental Pulp Stem Cells into Dopaminergic Neuron-like Cells in Vitro

Chun SY, Soker S, Jang YJ, Kwon TG, Yoo ES

We investigated the potential of human dental pulp stem cells (hDPSCs) to differentiate into dopaminergic neurons in vitro as an autologous stem cell source for Parkinson's disease treatment. The hDPSCs...
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Identification of a Novel Deletion Region in 3q29 Microdeletion Syndrome by Oligonucleotide Array Comparative Genomic Hybridization

Seo EJ, Jun KR, Yoo HW, Yoo HK, Lee JO

BACKGROUND: The 3q29 microdeletion syndrome is a genomic disorder characterized by mental retardation, developmental delay, microcephaly, and slight facial dysmorphism. In most cases, the microdeletion spans a 1.6-Mb region between...
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Serologic heterogeneity of HLA-A24 correlates with allelic types in the Korean population

Lee KW, Cho HC

HLA-A24 is the second most frequently expressed HLA-A type in Koreans (GF 22.8%). Four different serologic reaction patterns were observed in Korean A24 positive samples using a commercial serologic typing...
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