- Vascular endothelial dysfunction after anthracyclines treatment in children with acute lymphoblastic leukemia
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Jang WJ, Choi DY, Jeon IS
- KMID: 2284284
- Korean J Pediatr.
- 2013 Mar;56(3):130-134.
- doi: 10.3345/kjp.2013.56.3.130
PURPOSE: Anthracyclines have been utilized in the treatment of children with acute lymphoblastic leukemia (ALL). Recent studies have shown that anthracyclines may induce toxicity in the vascular endothelium. This study... -
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- Pathophysiology and preventive strategies of anthracycline-induced cardiotoxicity
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Chung WB, Youn HJ
- KMID: 2327736
- Korean J Intern Med.
- 2016 Jul;31(4):625-633.
- doi: 10.3904/kjim.2016.017
Cardiotoxicity is a well-known complication following treatment with anthracyclines. However, they are still widely used in chemotherapy for breast cancer, lymphoma, leukemia, and sarcoma, among others. Patient clinical characteristics, such... -
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- Successful Desensitization to Epirubicin in a Breast Cancer Patient with Doxorubicin Hypersensitivity
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- KMID: 2234614
- Korean J Asthma Allergy Clin Immunol.
- 2009 Jun;29(2):127-131.
Doxorubicin, a chemotherapeutic agent of the anthracycline family, has commonly been used to treat a wide range of cancers including leukemia, Hodgkin's lymphoma, and cancers of the breast, uterus, ovary... -
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- Cardiac Functional Evaluation Using Vector Velocity Imaging After Chemotherapy Including Anthracyclines in Children With Cancer
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Park JH, Kim YH, Hyun MC, Kim HS
- KMID: 2225670
- Korean Circ J.
- 2009 Sep;39(9):352-358.
- doi: 10.4070/kcj.2009.39.9.352
BACKGROUND AND OBJECTIVES: Anthracyclines are effective drugs that are widely used in pediatric cancer treatment. Previous studies have demonstrated that exposure to low-dose anthracyclines ( -
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- Follow-up Study of Children with Anthracycline Cardiotoxicity
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Kwon HJ, Song YH, Kang SJ, Kang HJ, Choi HS, Bae EJ, Shin HY, Noh CI, Yun YS, Ahn HS
- KMID: 2104618
- J Korean Pediatr Soc.
- 2003 Mar;46(3):242-249.
PURPOSE: We studied the relationship between anthracycline cumulative dose and anthracycline cardiotoxicity in childhood cancer and followed up 40 children with anthracycline cardiotoxicity. METHODS: A retrospective study was performed in 154... -
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- Changes in Protein Expression in Breast Cancer after Anthracycline-Based Chemotherapy
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Lee HC, Lee JO, Park IA
- KMID: 1521665
- Korean J Pathol.
- 2007 Jun;41(3):165-170.
Background : Anthracyclines are the standard agents used to treat patients with advanced breast carcinoma. Some molecules are reportedly associated with anthracycline resistance; however, there has been some controversy surrounding... -
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- Risk of Trastuzumab-Related Cardiotoxicity in Early Breast Cancer Patients: A Prospective Observational Study
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Xue J, Jiang Z, Qi F, Lv S, Zhang S, Wang T, Zhang X
- KMID: 2176128
- J Breast Cancer.
- 2014 Dec;17(4):363-369.
- doi: 10.4048/jbc.2014.17.4.363
PURPOSE: In the present study, we investigated the incidence of cardiotoxicity within 5 years of trastuzumab treatment and evaluated potential risk factors in clinical practice. METHODS: The study cohort included 415... -
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- Long-term cardiac composite risk following adjuvant treatment in breast cancer patients
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Choi HB, Yun S, Cho SW, Lee MH, Lee J, Park S
- KMID: 2432607
- Korean J Clin Oncol.
- 2018 Dec;14(2):102-107.
- doi: 10.14216/kjco.18018
PURPOSE: Cardiotoxicity is a serious late complication of breast cancer treatment. Individual treatment risk of specific drugs has been investigated. However, studies on the evaluation of the composite risk of... -
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- Prognostic Implications of Cytarabine Dose in Consolidation Chemotherapy for the Patients with Acute Myelogenous Leukemia
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Lee JH, Lee JH, Lee KH, Bahng H, Ahn JH, Lee JS, Kim SH, Kim WK
- KMID: 1815313
- J Korean Cancer Assoc.
- 2000 Oct;32(5):954-961.
PURPOSE: Increasing the dose of cytarabine in consolidation chemotherapy has been suggested to improve treatment outcome of the patients with acute myelogenous leukemia (AML) in complete remission (CR). We studied... -
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- QT Dispersion after Chemotherapy with Anthracyclines in Children
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Ko JK, Kim YH, Park IS, Seo JJ, Moon HN
- KMID: 2207415
- J Korean Pediatr Soc.
- 2001 Aug;44(8):908-915.
PURPOSE: Anthracycline induced cardiotoxicity is well known and its pathology is characterized by localized myocardial cell necrosis and myocardial fibrosis. The variability in QT interval duration amongst the different leads... -
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- A Case of Acute Myocardial Infarction In Man Treated with Chemotherapy containing Doxorubicin for Non-Hodgkin Lymphoma.
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Kim KH, Park WJ, Nam TM, Yoon DH, Heo PS, Doo YC, Han KR, Oh DJ, Yoo KH, Lim JY, Lee KH, Lee Y
- KMID: 2093814
- Korean Circ J.
- 2001 May;31(5):507-511.
- doi: 10.4070/kcj.2001.31.5.507
Anthracyclines have been widely used in cancer therapy because of their efficacy in the treatment of various solid tumors and hem -atologic malignancy. Cumulative dose-related cardiotoxicity was a well-known toxicity... -
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- Phase II Study of Vinorelbine Plus Trastuzumab in HER2 Overexpressing Metastatic Breast Cancer Pretreated with Anthracyclines and Taxanes
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Lee YR, Huh SJ, Lee DH, Yoon HH, Seol YM, Choi YJ, Kwon KA, Lee S, Oh SY, Kim SH, Kim HJ, Kwon HC
- KMID: 2286514
- J Breast Cancer.
- 2011 Jun;14(2):140-146.
- doi: 10.4048/jbc.2011.14.2.140
PURPOSE: The role of first-line trastuzumab-based therapy has been firmly established in patients with human epidermal growth factor receptor-2 (HER2) positive metastatic breast cancer. In this trial, we evaluated the... -
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- Recent advances in the diagnosis and management of childhood acute promyelocytic leukemia
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Yoo ES
- KMID: 2284373
- Korean J Pediatr.
- 2011 Mar;54(3):95-105.
- doi: 10.3345/kjp.2011.54.3.95
Since the successful introduction of all-trans-retinoic acid (ATRA) and its combination with anthracycline-containing chemotherapy, the prognosis for acute promyelocytic leukemia (APL) has markedly improved. With ATRA and anthracycline-based-chemotherapy, the complete... -
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- Interspecies pharmacokinetic scaling of 11-hydroxyaclanomycin X based on animal data
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Shin DH, Lee SY, Jeong SW, Park CW, Chung YB
- KMID: 2377352
- J Biomed Transl Res.
- 2017 Mar;18(1):24-29.
- doi: 10.12729/jbtr.2017.18.1.024
The pharmacokinetics of 11-Hydroxyaclacinomycin X (HAMX), a novel anthracycline, were investigated after intravenous bolus administration in mice, rats, rabbits and dogs. Based on animal data, we predicted the following human... -
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- Plasma B-type natriuretic peptide (BNP): a useful marker for anthracycline-induced cardiotoxicity in Korean children with cancer
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Lee HD, Lee JM, Lee YJ, Lee YH, Hah JO
- KMID: 2279200
- Korean J Pediatr.
- 2007 Aug;50(8):774-780.
- doi: 10.3345/kjp.2007.50.8.774
PURPOSE: The anthracyclines (AC) are widely used chemotherapeutic agents for pediatric cancers. However, the therapeutic use of these agents is limited by their cardiotoxicity. The aim of the present study... -
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- Reduced Dose Intensities of Doxorubicin in Elderly Patients with DLBCL in Rituximab Era
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Ha H, Keam B, Kim TM, Jeon YK, Lee SH, Kim DW, Kim CW, Heo DS
- KMID: 2152289
- Cancer Res Treat.
- 2016 Jan;48(1):304-311.
- doi: 10.4143/crt.2014.339
PURPOSE: The dose intensity of doxorubicin (DID) is important to the survival of diffuse large B cell lymphoma (DLBCL) patients. However, due to expected toxicities, most elderly patients cannot receive... -
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- Immunohistochemical Study on the Expression of Topoisomerase II alpha and Glutathione S-Transferase pi in Acute Myeloid Leukemia
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Kim BK, Jeong YS, Chang CH, Son HC, Kim SH, Sol MY, Lee EY
- KMID: 2089488
- Korean J Clin Pathol.
- 1998 Jun;18(2):107-114.
BACKGROUND: Topoisomerase II (topo II) is a major target of anthracyclines and epipodophyllotoxins for anticancer treatment. The expression of topo II is low in drug resistant cell lines. High levels... -
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- Risk Factor Analysis for Secondary Malignancy in Dexrazoxane-Treated Pediatric Cancer Patients
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Kim H, Kang HJ, Park KD, Koh KN, Im HJ, Seo JJ, Lee JW, Chung NG, Cho B, Kim HK, Lee JM, Hah JO, Lee JA, Lee YH, Park SK, Baek HJ, Kook H, Kim JY, Kim HS, Kim HM, Chueh HW, Park M, Yoon HS, Lee MJ, Choi HS, Ahn HS, Kawano Y, Park JW, Hahn S, Shin HY
- KMID: 2437626
- Cancer Res Treat.
- 2019 Jan;51(1):357-367.
- doi: 10.4143/crt.2017.457
PURPOSE: Dexrazoxane has been used as an effective cardioprotector against anthracycline cardiotoxicity. This study intended to analyze cardioprotective efficacy and secondary malignancy development, and elucidate risk factors for secondary malignancies... -
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- A Multicenter Clinical Study on Second Malignancies after Treatment of Childhood Cancer
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Seo JJ, Yoon SY, You CW, Shin HY, Ahn HS, Lyu CJ, Kim BS, Kim KY, Lee KS, Park JS, Kim HK, Moon HN
- KMID: 2278134
- Korean J Pediatr Hematol Oncol.
- 1998 Apr;5(1):113-121.
BACKGROUND: This study was undertaken to investigate the frequency, causes, and outcome of second malignancies(SM) following treatment of childhood cancer in Korea. METHODS: The Korean Society of Pediatric Hematology-Oncology(KSPHO) reviewed the... -
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- Chemotherapy-Induced Left Ventricular Dysfunction in Patients with Breast Cancer
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Yoon HJ, Kim KH, Kim JY, Park HJ, Cho JY, Hong YJ, Park HW, Kim JH, Ahn Y, Jeong MH, Cho JG, Park JC
- KMID: 2362926
- J Breast Cancer.
- 2016 Dec;19(4):402-409.
- doi: 10.4048/jbc.2016.19.4.402
PURPOSE: As the numbers of cancer cases and survivors increase, the incidence and natural history of chemotherapy-induced cardiotoxicities in patients with breast cancer may also be expected to change. The... -
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