Korean Circ J.  2001 May;31(5):507-511. 10.4070/kcj.2001.31.5.507.

A Case of Acute Myocardial Infarction In Man Treated with Chemotherapy containing Doxorubicin for Non-Hodgkin Lymphoma.

• Kim KH
• Park WJ
• Nam TM
• Yoon DH
• Heo PS
• Doo YC
• Han KR
• Oh DJ
• Yoo KH
• Lim JY
• Lee KH
• Lee Y

• KMID: 2093814
• DOI: http://doi.org/10.4070/kcj.2001.31.5.507

Abstract

Anthracyclines have been widely used in cancer therapy because of their efficacy in the treatment of various solid tumors and hem -atologic malignancy. Cumulative dose-related cardiotoxicity was a well-known toxicity of anthracyclines. Particularly, at total doses of more than 550 mg/m2, therapy with anthracyclines could produce irreversible cardiac injury. Anthracycline-induced cardiac toxicity was usually manifested by congestive heart failure or arrhythmia. In co- ntrast, acute myocardial infarction is a rare event of anthracycline-induced heart diseases. A 31-year-old man with non-Hodgkin lymphoma(NHL) and single cardiac risk factor, including smoking, was presented with chest pain after receiving 2nd CEOP-BLAM chemo-therapy. An electrocardiogram revealed ST segment elevation in inferior leads consistent with acute myocardial infarction. An echocardiogram revealed an ejection fraction of 60% and severe hypokinesia in inferior and anteroseptal wall. Three days later, coronary angiography revealed 50% of luminal stenosis of right coronary artery(RCA) and near total occlusion with large thrombi in m-RCA. After balloon angioplasty and stent insertion, the patient was transferred to coronary care unit and continuous intravenous heparin infusion was started. On the 10th days, the patient was discharged in good condition. Six months later, follow-up coronary angiography showed no significant lesion in right coronary artery. In a young man with NHL, we report an acute myocardial infarction after 2nd course of CEOP-BLAM chemotherapy with a review of relevant literatures.

MeSH Terms

Adult
Angioplasty, Balloon
Anthracyclines
Arrhythmias, Cardiac
Chest Pain
Constriction, Pathologic
Coronary Angiography
Coronary Care Units
Coronary Vessels
Doxorubicin*
Drug Therapy*
Electrocardiography
Follow-Up Studies
Heart Diseases
Heart Failure
Heparin
Humans
Hypokinesia
Lymphoma, Non-Hodgkin*
Myocardial Infarction*
Phenobarbital
Risk Factors
Smoke
Smoking
Stents
Anthracyclines
Doxorubicin
Heparin
Phenobarbital
Smoke