- Auranofin Suppresses Plasminogen Activator Inhibitor-2 Expression through Annexin A5 Induction in Human Prostate Cancer Cells
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Shin DW, Kwon YJ, Ye DJ, Baek HS, Lee JE, Chun YJ
- KMID: 2375038
- Biomol Ther.
- 2017 Mar;25(2):177-185.
- doi: 10.4062/biomolther.2016.223
Auranofin has been developed as antirheumatic drugs, which is currently under clinical development for the treatment of chronic lymphocytic leukemia. Previous report showed that auranofin induced apoptosis by enhancement of... -
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- Role of Annexin A5 on Mitochondria-Dependent Apoptosis Induced by Tetramethoxystilbene in Human Breast Cancer Cells
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Hong M, Park N, Chun YJ
- KMID: 2170593
- Biomol Ther.
- 2014 Nov;22(6):519-524.
- doi: 10.4062/biomolther.2014.112
We have previously shown that 2,4,3',5'-tetramethoxystilbene (TMS), a trans-stilbene analogue, induces apoptosis in human cancer cells. However, the detailed mechanisms of mitochondria-dependent apoptosis induced by TMS are not fully understood.... -
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- Annexin A5 as a New Potential Biomarker for Cisplatin-Induced Toxicity in Human Kidney Epithelial Cells
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Kwon YJ, Jung JJ, Park NH, Ye DJ, Kim D, Moon A, Chun YJ
- KMID: 1502486
- Biomol Ther.
- 2013 May;21(3):190-195.
Cisplatin is a member of platinum-containing anti-cancer drugs that causes cross-linking of DNA and ultimately cancer cell apoptosis. The therapeutic function of cisplatin on various types of cancers has been... -
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- In Vivo Nuclear Imaging of Apoptosis
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Lee TS, Cheon GJ
- KMID: 2078812
- Korean J Nucl Med.
- 2004 Apr;38(2):190-197.
Apoptosis plays a role in the pathophysiology of many kinds of diseases and in the response of treatment. Compared to the necrosis, the apoptosis is a genetically controlled and energy-dependent... -
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- Targeted Ultrasound Imaging of Apoptosis with Annexin A5 Microbubbles in Acute Doxorubicin-Induced Cardiotoxicity
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Min PK, Lim S, Kang SJ, Hong SY, Hwang KC, Chung KH, Shim CY, Rim SJ, Chung N
- KMID: 2177306
- J Cardiovasc Ultrasound.
- 2010 Sep;18(3):91-97.
- doi: 10.4250/jcu.2010.18.3.91
BACKGROUND: The aim of this study was to assess the feasibility of targeted ultrasound imaging on apoptosis with annexin A5 microbubbles (A5MB) in acute doxorubicin-induced cardiotoxicity. METHODS: Avidinated and octafluoropropan-filled phospholipid... -
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- Binding of Annexin V to Oxidized Lipid on Oxidatively Damaged Erythrocyte
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Lee KE, Lee KH, Choi YJ, Lee KH, Choi SH, Lee SH, Kim HJ, Lee KJ, Kim TH, Ko HS, Kim CJ, Ryu WS
- KMID: 1859056
- Korean Circ J.
- 2006 Apr;36(4):285-291.
- doi: 10.4070/kcj.2006.36.4.285
BACKGROUND AND OBJECTIVES: Annexin V is known to bind to the phosphatidylserine (PS) of damaged cell membranes. We recently demonstrated that annexin V binds to oxidized red blood cells (oxRBC).... -
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- Assessment of Cell Viability in Umbilical Cord Blood by Using 7-AAD/annexin V Dual Staining
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Kim KM, Huh JY, Kang MS, Jung SH
- KMID: 2312235
- Lab Med Online.
- 2014 Jan;4(1):1-7.
BACKGROUND: The quality of cord blood largely depends on cell viability. Viability assessments using trypan blue or 7-aminoactinomycin (7-AAD) staining, which are commonly used methods, may not reflect early apoptosis... -
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- Fas/FasL Expression in the Anterior Chamber Cells of Patients with Chronic Noninfectious Uveitis
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Kim NJ, Yu HG, Yu YS, Chung H
- KMID: 2206217
- J Korean Ophthalmol Soc.
- 2002 Oct;43(10):2017-2020.
PURPOSE: Despite ocular immune privilege, noninfectious chronic uveitis is relatively common. To investigate spontaneous turning on and off of noninfectious chronic uveitis, we examined the nature and apoptosis of infiltrating... -
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- The Effect of Magnesium Sulfate on Platelets Preserved at Cold Temperature
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Cho YG, Lee JH, Kim JT, Kim DS, Lee HS, Choi SI
- KMID: 1909654
- Korean J Blood Transfus.
- 2007 Dec;18(3):188-193.
BACKGROUND: It is known that magnesium can inhibit platelet function in vitro and ADP-induced platelet activation. We wished to demonstrate if magnesium could inhibit activation of platelets preserved at cold... -
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- Infected with Enterovirus
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Kim DS
- KMID: 2335475
- J Korean Pediatr Soc.
- 2000 Mar;43(3):372-379.
PURPOSE: To evaluate apoptosis of cord blood mononuclear cells (CBMC) infected with enterovirus. MEHTODS: Cord blood was obtained from 20 neonates which were delivered vaginally without any complications. Cord blood mononuclear... -
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- Neuroprotective Effect of Resveratrol on Acute Brain Ischemia Reperfusion Injury by Measuring Annexin V, p53, Bcl-2 Levels in Rats
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Kizmazoglu C, Aydin HE, Sevin IE, Kalemci O, Yuceer N, Atasoy MA
- KMID: 2151151
- J Korean Neurosurg Soc.
- 2015 Dec;58(6):508-512.
- doi: 10.3340/jkns.2015.58.6.508
BACKGROUND: Cerebral ischemia is as a result of insufficient cerebral blood flow for cerebral metabolic functions. Resveratrol is a natural phytoalexin that can be extracted from grape's skin and had... -
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- Apoptosis of Peripheral Blood Mononuclear Cells in Different Ages of Normal Children
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Kim DS, Kim HY, Linton JA
- KMID: 2207598
- J Korean Pediatr Soc.
- 2000 Apr;43(4):463-469.
PURPOSE: To survive in an ecological environment, an individual must develop immunity to various antigens. Therefore, populations of peripheral blood mononuclear cells (PBMC) in humans change continuously with growth. The... -
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- Detection of Apoptosis by the Stainings of Annexin V, Propidium Iodide and Cytokeratin in OVCAR-3 Ovarian Cancer Cell Line
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Song MK, Kwon MK, Lee JW, Choi YH, Kim TW, Ryu KS, Rha JG, Han KT
- KMID: 2272096
- Korean J Obstet Gynecol.
- 2003 Jul;46(7):1332-1340.
OBJECTIVE: This study was designed to estimate the chemosensitivity by a quantitative evaluation of the apoptotic cell fractions using flow cytometry. METHODS: The OVCAR-3 cells were exposed to 20 nM or... -
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- Oxidative Damage induced by UV in Cultured Retinal Pigment Epithelial Cells
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Yu HG, Choi KS, Heo JW, Kim KC, Kim YJ, Chung Y, Yu YS, Chung H
- KMID: 2206760
- J Korean Ophthalmol Soc.
- 2003 Dec;44(12):2890-2895.
PURPOSE: The death of retinal pigment epithelial(RPE) cells plays an important role in the development of age-related macular degeneration. We studied whether ultraviolet could induce apoptotic cell death and the... -
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- CD40 Activation Protects Dendritic Cells from Anticancer Drug-Induced Apoptosis
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Jun JY, Joo HG
- KMID: 1517041
- Korean J Physiol Pharmacol.
- 2003 Oct;7(5):255-260.
Dendritic cells (DCs) play a critical role in various immune responses involving CD4 T cells and have been used to generate anti-tumor immunity. Chemotherapy induces severe side effects including immunosuppression... -
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- Evaluation of Quality of Washed Platelets Stored in Platelet Additive Solutions
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Kim J, Kang J, Choi KY, Huh K
- KMID: 2379725
- Korean J Blood Transfus.
- 2017 Apr;28(1):67-76.
- doi: 10.17945/kjbt.2017.28.1.67
BACKGROUND: Because of a lack of substances for platelet (PLT) metabolism and preservation, normal saline (NS) washed PLTs can only be stored for short lengths of time. However, the use... -
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- Asiatic Acid Induces Apoptosis and Autophagy and Reduces MiR-17 and MiR-21 Expression in Pancreatic Cancer Cell Lines
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Jo YG, Kim M, Shin H, Lee KY, Lee EJ
- KMID: 2468062
- Nat Prod Sci.
- 2019 Dec;25(4):298-303.
- doi: 10.20307/nps.2019.25.4.298
This study investigated the cytotoxic effects and mechanism of action of asiatic acid in pancreatic cancer cell lines. First, we confirmed the cell viability of MIA PaCa-2 and PANC-1 cells... -
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- The Apoptosis Induced by Ceramide in the Endothelial Cell
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Lee SY, Kim TI, Tchag H
- KMID: 2206691
- J Korean Ophthalmol Soc.
- 2003 Sep;44(9):2128-2136.
PURPOSE: To evaluate the effect of variable ceramides on the apoptosis of corneal endothelial cell and then, if ceramide induce the apoptosis in endothelial cells, via which pathway apoptosis occur.... -
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- The Effect of IkappaBalpha-SR Gene Transfer on the Sensitivity of Human Lung Cancer Cell Lines to Cisplation and Paclitaxel
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Lee SY, Seol JY, Park KH, Park GM, Hwang YI, Kim CH, Jang SH, Kwon SY, Yoo CG, Kim YW, Han SK, Shim YS, Lee CT
- KMID: 2318344
- Tuberc Respir Dis.
- 2001 Aug;51(2):122-134.
- doi: 10.4046/trd.2001.51.2.122
BACKGROUND: Some chemotherapeutic drugs induce NF-κB activation by degrading the IκBα protein in cancer cells which contributes to anticancer drug resistance. We hypothesized that inhibiting IκBα degradation would block NF-κB... -
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- Apoptosis of Peripheral Mononuclear Cells in Patients with Aseptic Meningitis
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Kim HY, Kim DS
- KMID: 1551032
- Korean J Infect Dis.
- 1999 Feb;31(1):9-16.
BACKGROUND: The object of this study was to evaluate apoptosis of peripheral blood mononuclear cells (PBMC) in patients with aseptic meningitis and to determine whether Fas-FasL system is involved in... -
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